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Article: Determinants of leukocyte adenosine triphosphate-binding cassette transporter G1 gene expression in type 2 diabetes mellitus

TitleDeterminants of leukocyte adenosine triphosphate-binding cassette transporter G1 gene expression in type 2 diabetes mellitus
Authors
Issue Date2008
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 2008, v. 57 n. 8, p. 1135-1140 How to Cite?
AbstractCellular cholesterol efflux is regulated by cholesterol transporters including adenosine triphosphate-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). We have investigated whether the expression of these transporters is affected by type 2 diabetes mellitus and the association with glycemic indexes and oxidized low-density lipoprotein (oxLDL). Messenger RNA of ABCA1, ABCG1, and SR-BI in peripheral monocytes was measured in 30 diabetic patients and 30 matched controls. Plasma oxLDL and advanced glycation end products (AGEs) were assayed by enzyme-linked immunosorbent assay. Cellular cholesterol efflux from monocytes to serum was determined in a subgroup chosen randomly. The expression of ABCG1 was decreased in diabetic patients (P < .05), whereas the levels of ABCA1 and SR-BI were comparable between the 2 groups. Fasting glucose, hemoglobin A1c, AGEs, and oxLDL were all significantly increased in diabetic patients. There was an inverse correlation between serum AGEs and ABCG1 (r = -0.44, P < .05) that remained significant after adjusting for potential confounding factors. No associations between fasting glucose, hemoglobin A1c, plasma lipids, or oxLDL and the expression of ABCG1, ABCA1, or SR-BI were found. Cholesterol efflux from monocytes to standard serum or autologous serum was significantly impaired in diabetic patients, and the reduction in efflux to autologous serum correlated with the expression of ABCG1 (r = 0.60, P < .05). The expression of ABCG1 in monocytes is reduced in type 2 diabetes mellitus and is partly related to serum AGEs concentration. The reduction in ABCG1 is associated with impairment in cholesterol efflux and may contribute to accelerated foam cell formation in diabetic patients. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59362
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.date.accessioned2010-05-31T03:48:27Z-
dc.date.available2010-05-31T03:48:27Z-
dc.date.issued2008en_HK
dc.identifier.citationMetabolism: Clinical And Experimental, 2008, v. 57 n. 8, p. 1135-1140en_HK
dc.identifier.issn0026-0495en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59362-
dc.description.abstractCellular cholesterol efflux is regulated by cholesterol transporters including adenosine triphosphate-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI). We have investigated whether the expression of these transporters is affected by type 2 diabetes mellitus and the association with glycemic indexes and oxidized low-density lipoprotein (oxLDL). Messenger RNA of ABCA1, ABCG1, and SR-BI in peripheral monocytes was measured in 30 diabetic patients and 30 matched controls. Plasma oxLDL and advanced glycation end products (AGEs) were assayed by enzyme-linked immunosorbent assay. Cellular cholesterol efflux from monocytes to serum was determined in a subgroup chosen randomly. The expression of ABCG1 was decreased in diabetic patients (P < .05), whereas the levels of ABCA1 and SR-BI were comparable between the 2 groups. Fasting glucose, hemoglobin A1c, AGEs, and oxLDL were all significantly increased in diabetic patients. There was an inverse correlation between serum AGEs and ABCG1 (r = -0.44, P < .05) that remained significant after adjusting for potential confounding factors. No associations between fasting glucose, hemoglobin A1c, plasma lipids, or oxLDL and the expression of ABCG1, ABCA1, or SR-BI were found. Cholesterol efflux from monocytes to standard serum or autologous serum was significantly impaired in diabetic patients, and the reduction in efflux to autologous serum correlated with the expression of ABCG1 (r = 0.60, P < .05). The expression of ABCG1 in monocytes is reduced in type 2 diabetes mellitus and is partly related to serum AGEs concentration. The reduction in ABCG1 is associated with impairment in cholesterol efflux and may contribute to accelerated foam cell formation in diabetic patients. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_HK
dc.relation.ispartofMetabolism: Clinical and Experimentalen_HK
dc.subject.meshATP-Binding Cassette Transporters - biosynthesis - blood - geneticsen_HK
dc.subject.meshBiological Transporten_HK
dc.subject.meshBlood Glucose - metabolismen_HK
dc.subject.meshCholesterol - blooden_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blood - geneticsen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshGlycosylation End Products, Advanced - blooden_HK
dc.subject.meshHemoglobin A, Glycosylated - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukocytes, Mononuclear - metabolismen_HK
dc.subject.meshLipoproteins, LDL - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRNA, Messenger - blood - geneticsen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshScavenger Receptors, Class B - biosynthesis - blood - geneticsen_HK
dc.subject.meshTriglycerides - metabolismen_HK
dc.titleDeterminants of leukocyte adenosine triphosphate-binding cassette transporter G1 gene expression in type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.metabol.2008.03.020en_HK
dc.identifier.pmid18640393-
dc.identifier.scopuseid_2-s2.0-47149101517en_HK
dc.identifier.hkuros158349en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47149101517&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1135en_HK
dc.identifier.epage1140en_HK
dc.identifier.isiWOS:000258196300018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, H=24077909100en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridWong, Y=24073787400en_HK

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