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Article: Determinants of lesion dimensions during transcatheter microwave ablation

TitleDeterminants of lesion dimensions during transcatheter microwave ablation
Authors
KeywordsAblation
Lesion
Microwave
Radiofrequency
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0147-8389&site=1
Citation
PACE - Pacing And Clinical Electrophysiology, 2009, v. 32 n. 2, p. 201-208 How to Cite?
AbstractBackground: Transcatheter microwave ablation is a novel technique for treating cardiac arrhythmias. Methods: We investigated the effects of catheter temperature, application duration, and antenna length on lesion dimensions during catheter-based microwave ablation. In a swine thigh muscle preparation, microwave was delivered at targeted temperatures of 60°C (n = 18), 70°C (n = 27), 80°C (n = 43), or 90°C (n = 18) for 120 seconds with 10-mm antenna; and at targeted temperatures of 80°C for 120 seconds (n = 22), 150 seconds (n = 18), 180 seconds (n = 18), 210 seconds (n = 18), and 240 seconds (n = 17) with 20-mm antenna using 10 F catheter (MedWaves, San Diego, CA, USA) during parallel orientation. Conventional radiofrequency ablation (RF) using a 4-mm tip electrode was performed as control. Results: With 120-second energy applications, lesion length and depth were significantly larger with targeted temperatures of 80°C and 90°C than 60°C (P< 0.05). Furthermore, lesion depth and width, but not length, were significantly increased by prolonging energy application duration from 120 to 240 seconds at targeted temperature of 80°C (P< 0.05). Compared to RF, microwave lesions were significantly longer but had comparable depth and width. A 20-mm microwave antenna produced longer lesions than either a 10-mm antenna or RF ablation catheter. Multivariate analysis demonstrated that targeted temperature ≥80°C, application duration ≥150 seconds, and use of 20-mm antenna were independent predictors for lesion depth and width (P< 0.05). Surface dessication was observed in 4/18 (22%) lesions at 90°C, as compared with 1/136 (0.7%) at 80°C targeted tip temperature (P < 0.05). Conclusions: This study demonstrated that lesions size with transcatheter microwave ablation can be controlled by adjusting targeted temperature, energy application duration, and antenna length. A targeted temperature of 80°C for more than 150 seconds should provide optimal lesion dimensions and lower risk of surface dessication or charring. © 2009, The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/59354
ISSN
2015 Impact Factor: 1.156
2015 SCImago Journal Rankings: 0.662
ISI Accession Number ID
Funding AgencyGrant Number
MedWaves Inc., San Diego, California, USA
Funding Information:

The study was supported in part by a grant from MedWaves Inc., San Diego, California, USA.

References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLiao, Sen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorYuan, Len_HK
dc.contributor.authorNicholls, Jen_HK
dc.contributor.authorLeung, Gen_HK
dc.contributor.authorOrmsby, Ten_HK
dc.contributor.authorFeld, GKen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-05-31T03:48:18Z-
dc.date.available2010-05-31T03:48:18Z-
dc.date.issued2009en_HK
dc.identifier.citationPACE - Pacing And Clinical Electrophysiology, 2009, v. 32 n. 2, p. 201-208en_HK
dc.identifier.issn0147-8389en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59354-
dc.description.abstractBackground: Transcatheter microwave ablation is a novel technique for treating cardiac arrhythmias. Methods: We investigated the effects of catheter temperature, application duration, and antenna length on lesion dimensions during catheter-based microwave ablation. In a swine thigh muscle preparation, microwave was delivered at targeted temperatures of 60°C (n = 18), 70°C (n = 27), 80°C (n = 43), or 90°C (n = 18) for 120 seconds with 10-mm antenna; and at targeted temperatures of 80°C for 120 seconds (n = 22), 150 seconds (n = 18), 180 seconds (n = 18), 210 seconds (n = 18), and 240 seconds (n = 17) with 20-mm antenna using 10 F catheter (MedWaves, San Diego, CA, USA) during parallel orientation. Conventional radiofrequency ablation (RF) using a 4-mm tip electrode was performed as control. Results: With 120-second energy applications, lesion length and depth were significantly larger with targeted temperatures of 80°C and 90°C than 60°C (P< 0.05). Furthermore, lesion depth and width, but not length, were significantly increased by prolonging energy application duration from 120 to 240 seconds at targeted temperature of 80°C (P< 0.05). Compared to RF, microwave lesions were significantly longer but had comparable depth and width. A 20-mm microwave antenna produced longer lesions than either a 10-mm antenna or RF ablation catheter. Multivariate analysis demonstrated that targeted temperature ≥80°C, application duration ≥150 seconds, and use of 20-mm antenna were independent predictors for lesion depth and width (P< 0.05). Surface dessication was observed in 4/18 (22%) lesions at 90°C, as compared with 1/136 (0.7%) at 80°C targeted tip temperature (P < 0.05). Conclusions: This study demonstrated that lesions size with transcatheter microwave ablation can be controlled by adjusting targeted temperature, energy application duration, and antenna length. A targeted temperature of 80°C for more than 150 seconds should provide optimal lesion dimensions and lower risk of surface dessication or charring. © 2009, The Authors.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0147-8389&site=1en_HK
dc.relation.ispartofPACE - Pacing and Clinical Electrophysiologyen_HK
dc.subjectAblationen_HK
dc.subjectLesionen_HK
dc.subjectMicrowaveen_HK
dc.subjectRadiofrequencyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBody Temperatureen_HK
dc.subject.meshCatheter Ablation - methodsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshMicrowaves - therapeutic useen_HK
dc.subject.meshMuscle, Skeletal - pathology - physiology - surgeryen_HK
dc.subject.meshSwineen_HK
dc.titleDeterminants of lesion dimensions during transcatheter microwave ablationen_HK
dc.typeArticleen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailNicholls, J:nicholls@pathology.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityNicholls, J=rp00364en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8159.2008.02203.xen_HK
dc.identifier.pmid19170909-
dc.identifier.scopuseid_2-s2.0-58849122722en_HK
dc.identifier.hkuros158353en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58849122722&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage208en_HK
dc.identifier.isiWOS:000262689400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLiao, S=22433820700en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridYuan, L=36820800500en_HK
dc.identifier.scopusauthoridNicholls, J=7201463077en_HK
dc.identifier.scopusauthoridLeung, G=23489330100en_HK
dc.identifier.scopusauthoridOrmsby, T=26023605400en_HK
dc.identifier.scopusauthoridFeld, GK=7005074639en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.citeulike3957546-

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