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Article: Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: A study of 136 cases from the International Peripheral T-Cell Lymphoma Project

TitleClinical differences between nasal and extranasal natural killer/T-cell lymphoma: A study of 136 cases from the International Peripheral T-Cell Lymphoma Project
Authors
Issue Date2009
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2009, v. 113 n. 17, p. 3931-3937 How to Cite?
AbstractAmong 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and in Continental Asia than in Japan. There were no differences in age, sex, ethnicity, or immunophenotypic profile between the nasal and extranasal cases, but the latter had more adverse clinical features. The median overall survival (OS) was better in nasal compared with the extranasal cases in early- (2.96 vs 0.36 years, P < .001) and late-stage disease (0.8 vs 0.28 years, P = .031). The addition of radiotherapy for early-stage nasal cases yielded survival benefit (P = .045).Among nasal cases, both the International Prognostic Index (P = .006) and Korean NK/T-cell Prognostic Index (P < .001) were prognostic. In addition, Ki67 proliferation greater than 50%, transformed tumor cells greater than 40%, elevated C-reactive protein level (CRP), anemia (< 11 g/dL) and thrombocytopenia (< 150 × 10 9/L) predicts poorer OS for nasal disease. No histologic or clinical feature was predictive in extranasal disease. We conclude that the clinical features and treatment response of extranasal NK/T-cell lymphoma are different from of those of nasal lymphoma. However, the underlying features responsible for these differences remain to be defined. © 2009 by The American Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/59308
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorWeisenburger, DDen_HK
dc.contributor.authorIntragumtornchai, Ten_HK
dc.contributor.authorNakamura, Sen_HK
dc.contributor.authorKim, WSen_HK
dc.contributor.authorSng, Ien_HK
dc.contributor.authorVose, Jen_HK
dc.contributor.authorArmitage, JOen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-05-31T03:47:26Z-
dc.date.available2010-05-31T03:47:26Z-
dc.date.issued2009en_HK
dc.identifier.citationBlood, 2009, v. 113 n. 17, p. 3931-3937en_HK
dc.identifier.issn0006-4971en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59308-
dc.description.abstractAmong 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and in Continental Asia than in Japan. There were no differences in age, sex, ethnicity, or immunophenotypic profile between the nasal and extranasal cases, but the latter had more adverse clinical features. The median overall survival (OS) was better in nasal compared with the extranasal cases in early- (2.96 vs 0.36 years, P < .001) and late-stage disease (0.8 vs 0.28 years, P = .031). The addition of radiotherapy for early-stage nasal cases yielded survival benefit (P = .045).Among nasal cases, both the International Prognostic Index (P = .006) and Korean NK/T-cell Prognostic Index (P < .001) were prognostic. In addition, Ki67 proliferation greater than 50%, transformed tumor cells greater than 40%, elevated C-reactive protein level (CRP), anemia (< 11 g/dL) and thrombocytopenia (< 150 × 10 9/L) predicts poorer OS for nasal disease. No histologic or clinical feature was predictive in extranasal disease. We conclude that the clinical features and treatment response of extranasal NK/T-cell lymphoma are different from of those of nasal lymphoma. However, the underlying features responsible for these differences remain to be defined. © 2009 by The American Society of Hematology.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_HK
dc.relation.ispartofBlooden_HK
dc.rightsThis research was originally published in The Hematologist: ASH News and Reports. Author(s). Title. The Hematologist: ASH News and Reports. Year;Vol,Issue:pp-pp. © the American Society of Hematology.-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshLymphoma, T-Cell - classification - epidemiology - genetics - pathology-
dc.subject.meshNose Neoplasms - classification - epidemiology - genetics - pathology-
dc.titleClinical differences between nasal and extranasal natural killer/T-cell lymphoma: A study of 136 cases from the International Peripheral T-Cell Lymphoma Projecten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-4971&volume=113&issue=17&spage=3931&epage=3937&date=2009&atitle=Clinical+differences+between+nasal+and+extranasal+natural+killer/T-cell+lymphoma:+a+study+of+136+cases+from+the+International+Peripheral+T-cell+Lymphoma+Projecten_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1182/blood-2008-10-185256en_HK
dc.identifier.pmid19029440-
dc.identifier.scopuseid_2-s2.0-65449159015en_HK
dc.identifier.hkuros161852en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65449159015&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume113en_HK
dc.identifier.issue17en_HK
dc.identifier.spage3931en_HK
dc.identifier.epage3937en_HK
dc.identifier.isiWOS:000265447000010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridWeisenburger, DD=7102337715en_HK
dc.identifier.scopusauthoridIntragumtornchai, T=7003552362en_HK
dc.identifier.scopusauthoridNakamura, S=35323670300en_HK
dc.identifier.scopusauthoridKim, WS=34975082200en_HK
dc.identifier.scopusauthoridSng, I=6701338442en_HK
dc.identifier.scopusauthoridVose, J=35239028600en_HK
dc.identifier.scopusauthoridArmitage, JO=7202699346en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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