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Article: Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes

TitleDaily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes
Authors
Issue Date2008
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/117935711/grouphome/home.html
Citation
Molecular Nutrition And Food Research, 2008, v. 52 n. 12, p. 1421-1427 How to Cite?
AbstractOur objective was to determine the relationships between levels of different dietary nutrients intake with circulating endothelial progenitor cells (EPC) and vascular endothelial function in type II diabetic patients. We studied the daily dietary nutrients intake, the numbers of circulating CD34 +/KDR+ EPC and CD133+/KDR+ EPC and brachial artery flow-mediated dilation (FMD) in 88 diabetic patients without prior cardiovascular diseases and 91 sex- and age-matched controls. Compared with controls, diabetic patients had lower CD133+/KDR+ EPC count (48.3 ± 5.2 vs. 84.6 ± 7.6/μL, p < 0.001), CD34 +/KDR+ EPC count (311 ± 41 vs. 412 ± 36/μL, p = 0.045), and FMD (2.54 ± 0.37% vs. 5.46 ± 0.47%, p < 0.001). After adjusted for age, sex, smoking history, body weight, hemoglobin A1c level, total calorie intake, other dietary vitamin intake, use of antihypertensives, and lipid lowering agents, a higher intake of thiamine was significantly associated with a higher level of circulating CD34 +/KDR+ EPC (β = 0.49, p = 0.028) and CD133 +/KDR+ EPC (β = 0.45, p = 0.037) in diabetic patients, but not in controls. Furthermore, an increased intake of thiamine from 1st to 4th quartile in diabetic patients independently predicted an absolute increase in FMD by 1.29% (p = 0.026, relative increase = 63.5%). This study demonstrated that daily thiamine intake was positively correlated with the circulating number of EPCs and FMD in patients with type II diabetes, independent of other dietary nutrients intake. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/59302
ISSN
2015 Impact Factor: 4.551
2015 SCImago Journal Rankings: 1.679
ISI Accession Number ID
Funding AgencyGrant Number
CRCG Small Project Funding of University of Hong Kong20050717613
Sun Chieh Yeh Heart Fundation
Funding Information:

This study was supported by the CRCG Small Project Funding of University of Hong Kong (project no. 20050717613 7). and Sun Chieh Yeh Heart Fundation.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, CYen_HK
dc.contributor.authorQiuwaxi, Jen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorShu, XOen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-05-31T03:47:19Z-
dc.date.available2010-05-31T03:47:19Z-
dc.date.issued2008en_HK
dc.identifier.citationMolecular Nutrition And Food Research, 2008, v. 52 n. 12, p. 1421-1427en_HK
dc.identifier.issn1613-4125en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59302-
dc.description.abstractOur objective was to determine the relationships between levels of different dietary nutrients intake with circulating endothelial progenitor cells (EPC) and vascular endothelial function in type II diabetic patients. We studied the daily dietary nutrients intake, the numbers of circulating CD34 +/KDR+ EPC and CD133+/KDR+ EPC and brachial artery flow-mediated dilation (FMD) in 88 diabetic patients without prior cardiovascular diseases and 91 sex- and age-matched controls. Compared with controls, diabetic patients had lower CD133+/KDR+ EPC count (48.3 ± 5.2 vs. 84.6 ± 7.6/μL, p < 0.001), CD34 +/KDR+ EPC count (311 ± 41 vs. 412 ± 36/μL, p = 0.045), and FMD (2.54 ± 0.37% vs. 5.46 ± 0.47%, p < 0.001). After adjusted for age, sex, smoking history, body weight, hemoglobin A1c level, total calorie intake, other dietary vitamin intake, use of antihypertensives, and lipid lowering agents, a higher intake of thiamine was significantly associated with a higher level of circulating CD34 +/KDR+ EPC (β = 0.49, p = 0.028) and CD133 +/KDR+ EPC (β = 0.45, p = 0.037) in diabetic patients, but not in controls. Furthermore, an increased intake of thiamine from 1st to 4th quartile in diabetic patients independently predicted an absolute increase in FMD by 1.29% (p = 0.026, relative increase = 63.5%). This study demonstrated that daily thiamine intake was positively correlated with the circulating number of EPCs and FMD in patients with type II diabetes, independent of other dietary nutrients intake. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/117935711/grouphome/home.htmlen_HK
dc.relation.ispartofMolecular Nutrition and Food Researchen_HK
dc.subject.meshBrachial Artery - physiologyen_HK
dc.subject.meshCell Counten_HK
dc.subject.meshDiabetes Mellitus, Type 2 - complications - physiopathologyen_HK
dc.subject.meshDiabetic Angiopathies - prevention & controlen_HK
dc.subject.meshEndothelial Cells - physiologyen_HK
dc.subject.meshEndothelium, Vascular - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFruiten_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshStem Cells - physiologyen_HK
dc.subject.meshThiamine - administration & dosage - blooden_HK
dc.subject.meshVegetablesen_HK
dc.titleDaily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1613-4125&volume=52 &issue=12&spage=1421 &epage= 1427&date=2008&atitle=Daily+intake+of+thiamine+correlates+with+the+circulating+level+of+endothelial+progenitor+cells+and+the+endothelial+function+in+patients+with+type+II+diabetesen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mnfr.200800056en_HK
dc.identifier.pmid18925614-
dc.identifier.scopuseid_2-s2.0-57549096928en_HK
dc.identifier.hkuros159793en_HK
dc.identifier.hkuros140857-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57549096928&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1421en_HK
dc.identifier.epage1427en_HK
dc.identifier.isiWOS:000262184500004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWong, CY=36862848300en_HK
dc.identifier.scopusauthoridQiuwaxi, J=25923529900en_HK
dc.identifier.scopusauthoridChen, H=20733607100en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridShu, XO=7102525083en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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