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Article: Commonly used animal models of non-alcoholic steatohepatitis

TitleCommonly used animal models of non-alcoholic steatohepatitis
Authors
Issue Date2009
PublisherThe First Affiliated Hospital. The Journal's web site is located at http://www.hbpdint.com/
Citation
Hepatobiliary & Pancreatic Diseases International, 2009, v. 8 n. 3, p. 233-240 How to Cite?
AbstractBACKGROUND: Animal models are an essential tool in non-alcoholic steatohepatitis (NASH) studies. Ideally, such models should reflect the etiology, disease progression, and the established pathology of human NASH. To date, no single animal model displays the range of histopathologic and pathophysiologic features associated with human NASH. The currently available models do not or only partially reflect the real picture of human NASH. In particular, insulin resistance and fibrosing steatohepatitis are rarely reproduced by the currently available models. Consequently, it is necessary to establish NASH models that can best mimic the real etiology, disease progression, and pathogenesis of human NASH. DATA SOURCES: We reviewed the major currently available animal models published in the literature (PubMed) and briefly commented on the pros and cons of these models. RESULT: Three major categories of animal models, genetic, dietary, and combination models, were reviewed and discussed. CONCLUSIONS: Animal models are not only useful in revealing the etiology of NASH, but also are important platforms for the assessment of therapeutic strategies. Currently available models do not reflect the full picture of NASH in patients. Better animal models are needed for a full understanding of human NASH and the development of efficient therapies for this condition.
Persistent Identifierhttp://hdl.handle.net/10722/59298
ISSN
2015 Impact Factor: 1.724
2015 SCImago Journal Rankings: 0.717

 

DC FieldValueLanguage
dc.contributor.authorFan, JGen_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-05-31T03:47:14Z-
dc.date.available2010-05-31T03:47:14Z-
dc.date.issued2009en_HK
dc.identifier.citationHepatobiliary & Pancreatic Diseases International, 2009, v. 8 n. 3, p. 233-240en_HK
dc.identifier.issn1499-3872-
dc.identifier.urihttp://hdl.handle.net/10722/59298-
dc.description.abstractBACKGROUND: Animal models are an essential tool in non-alcoholic steatohepatitis (NASH) studies. Ideally, such models should reflect the etiology, disease progression, and the established pathology of human NASH. To date, no single animal model displays the range of histopathologic and pathophysiologic features associated with human NASH. The currently available models do not or only partially reflect the real picture of human NASH. In particular, insulin resistance and fibrosing steatohepatitis are rarely reproduced by the currently available models. Consequently, it is necessary to establish NASH models that can best mimic the real etiology, disease progression, and pathogenesis of human NASH. DATA SOURCES: We reviewed the major currently available animal models published in the literature (PubMed) and briefly commented on the pros and cons of these models. RESULT: Three major categories of animal models, genetic, dietary, and combination models, were reviewed and discussed. CONCLUSIONS: Animal models are not only useful in revealing the etiology of NASH, but also are important platforms for the assessment of therapeutic strategies. Currently available models do not reflect the full picture of NASH in patients. Better animal models are needed for a full understanding of human NASH and the development of efficient therapies for this condition.-
dc.languageengen_HK
dc.publisherThe First Affiliated Hospital. The Journal's web site is located at http://www.hbpdint.com/-
dc.relation.ispartofHepatobiliary & Pancreatic Diseases Internationalen_HK
dc.subject.meshAnimals-
dc.subject.meshDiet-
dc.subject.meshDisease Models, Animal-
dc.subject.meshDisease Progression-
dc.subject.meshFatty Liver - etiology - genetics - pathology - physiopathology-
dc.subject.meshInflammation - pathology-
dc.titleCommonly used animal models of non-alcoholic steatohepatitisen_HK
dc.typeArticleen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19502161-
dc.identifier.hkuros155754en_HK
dc.identifier.volume8-
dc.identifier.issue3-
dc.identifier.spage233-
dc.identifier.epage240-
dc.publisher.placeChina-

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