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Article: Atypical femoral diaphyseal and subtrochanteric fractures and their association with bisphosphonates

TitleAtypical femoral diaphyseal and subtrochanteric fractures and their association with bisphosphonates
Authors
Issue Date2009
PublisherBMJ Group. The Journal's web site is located at http://casereports.bmj.com
Citation
BMJ Case Reports, 5 March 2009 How to Cite?
AbstractSummary: Antiresorptive bisphosphonate agents are the mainstay of treatment for osteoporosis in both men and postmenopausal women. However, recent studies have raised concerns about the oversuppression of bone turnover related to the long-term use of bisphosphonates. Cases of atypical femoral diaphyseal and subtrochanteric fracture were reported recently in patients on long-term alendronate, and oversuppression of bone turnover was postulated to be the cause. We retrospectively reviewed all patients with femoral diaphyseal and subtrochanteric fracture presented between July 2003 and June 2008, and identified 10 patients who reported prior bisphosphonate use. Bone formation markers of all these patients were in the low range. Although the incidence of bisphosphonate-related atypical fracture accounts for an extremely low percentage of the total number of femoral diaphyseal and subtrochanteric fractures, we observed a steady increase from 0% in 2003 to 2004 to 25% in 2007 to 2008.
Persistent Identifierhttp://hdl.handle.net/10722/59285
ISSN
2015 SCImago Journal Rankings: 0.137
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Fen_HK
dc.contributor.authorLau, TWen_HK
dc.contributor.authorTo, Men_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-05-31T03:47:00Z-
dc.date.available2010-05-31T03:47:00Z-
dc.date.issued2009en_HK
dc.identifier.citationBMJ Case Reports, 5 March 2009en_HK
dc.identifier.issn1757-790X-
dc.identifier.urihttp://hdl.handle.net/10722/59285-
dc.description.abstractSummary: Antiresorptive bisphosphonate agents are the mainstay of treatment for osteoporosis in both men and postmenopausal women. However, recent studies have raised concerns about the oversuppression of bone turnover related to the long-term use of bisphosphonates. Cases of atypical femoral diaphyseal and subtrochanteric fracture were reported recently in patients on long-term alendronate, and oversuppression of bone turnover was postulated to be the cause. We retrospectively reviewed all patients with femoral diaphyseal and subtrochanteric fracture presented between July 2003 and June 2008, and identified 10 patients who reported prior bisphosphonate use. Bone formation markers of all these patients were in the low range. Although the incidence of bisphosphonate-related atypical fracture accounts for an extremely low percentage of the total number of femoral diaphyseal and subtrochanteric fractures, we observed a steady increase from 0% in 2003 to 2004 to 25% in 2007 to 2008.-
dc.languageengen_HK
dc.publisherBMJ Group. The Journal's web site is located at http://casereports.bmj.com-
dc.relation.ispartofBMJ Case Reportsen_HK
dc.rightsBMJ Case Reports. Copyright © BMJ Group.-
dc.rightsThe following statements must accompany the articles posted on the Contributor(s)’s and/or his/her institution’s website: Locked and research funded articles acknowledgement: This article has been accepted for publication in [Contributor, please insert journal name]. The definitive copyedited, typeset version [Contributor please insert complete citation information when available] is available online at: www. [Contributor please insert as applicable] .com Unlocked article acknowledgement: This article has been accepted for publication in [Contributor please insert full citation] following peer review and can also be viewed on the journal’s website at www. [Contributor please insert as applicable] .com-
dc.titleAtypical femoral diaphyseal and subtrochanteric fractures and their association with bisphosphonatesen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, F: klleunga@hku.hken_HK
dc.identifier.emailLau, TW: catcher@hkucc.hku.hken_HK
dc.identifier.emailTo, M: mikektto@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityLeung, FKL=rp00297en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1136/bcr.10.2008.1073-
dc.identifier.pmid21686468-
dc.identifier.pmcidPMC3027310-
dc.identifier.hkuros166510en_HK
dc.identifier.eissn1757-790X-
dc.publisher.placeUnited Kingdom-

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