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Article: High frequency of polyoma BK virus shedding in the gastrointestinal tract after hematopoietic stem cell transplantation: A prospective and quantitative analysis

TitleHigh frequency of polyoma BK virus shedding in the gastrointestinal tract after hematopoietic stem cell transplantation: A prospective and quantitative analysis
Authors
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2009, v. 43 n. 1, p. 43-47 How to Cite?
AbstractThe polyoma BK virus (BKV) remains latent after primary infection and may reactivate during immunosuppression. The uroepithelium is the main latency site defined. This study addressed whether the gastrointestinal tract might be another latency site. To test this hypothesis, we prospectively quantified fecal BKV by quantitative PCR reaction in 40 patients undergoing hematopoietic SCT (HSCT). Urinary BKV was similarly quantified. Fecal BKV excretion was positive in 16/40 patients, of whom 10 were transient (<3 consecutively positive samples), six were persistent (≥3 consecutively positive samples) and three were persistent with peaking (≥103-fold increase in viral load over baseline, reaching 5.11 × 106, 4.68 × 107 and 2.75 × 108 copies/sample at 14, 14 and 21 days post-HSCT, respectively). Urinary BKV excretion was positive in 25/40 patients. Fecal BKV excretion was significantly correlated with that of the urine (P = 0.036) and was significantly associated with allogeneic HSCT (P = 0.037) and persistent and peaking of urinary BKV excretion (P < 0.001). Binary logistic regression showed that BKV viruria was the only significant risk factor for fecal BKV excretion (P = 0.021). Fecal BKV excretion occurred in 40% patients undergoing HSCT, implicating the gastrointestinal tract as a BKV latency site.
Persistent Identifierhttp://hdl.handle.net/10722/59248
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, ASYen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLeung, AYHen_HK
dc.date.accessioned2010-05-31T03:46:06Z-
dc.date.available2010-05-31T03:46:06Z-
dc.date.issued2009en_HK
dc.identifier.citationBone Marrow Transplantation, 2009, v. 43 n. 1, p. 43-47en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59248-
dc.description.abstractThe polyoma BK virus (BKV) remains latent after primary infection and may reactivate during immunosuppression. The uroepithelium is the main latency site defined. This study addressed whether the gastrointestinal tract might be another latency site. To test this hypothesis, we prospectively quantified fecal BKV by quantitative PCR reaction in 40 patients undergoing hematopoietic SCT (HSCT). Urinary BKV was similarly quantified. Fecal BKV excretion was positive in 16/40 patients, of whom 10 were transient (<3 consecutively positive samples), six were persistent (≥3 consecutively positive samples) and three were persistent with peaking (≥103-fold increase in viral load over baseline, reaching 5.11 × 106, 4.68 × 107 and 2.75 × 108 copies/sample at 14, 14 and 21 days post-HSCT, respectively). Urinary BKV excretion was positive in 25/40 patients. Fecal BKV excretion was significantly correlated with that of the urine (P = 0.036) and was significantly associated with allogeneic HSCT (P = 0.037) and persistent and peaking of urinary BKV excretion (P < 0.001). Binary logistic regression showed that BKV viruria was the only significant risk factor for fecal BKV excretion (P = 0.021). Fecal BKV excretion occurred in 40% patients undergoing HSCT, implicating the gastrointestinal tract as a BKV latency site.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subject.meshBK Virus - genetics - isolation & purification - physiologyen_HK
dc.subject.meshFeces - virologyen_HK
dc.subject.meshGastrointestinal Tract - chemistry - virologyen_HK
dc.subject.meshGraft vs Host Disease - immunologyen_HK
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolyomavirus Infections - immunology - urine - virologyen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshTumor Virus Infections - immunology - urine - virologyen_HK
dc.subject.meshVirus Latencyen_HK
dc.subject.meshVirus Sheddingen_HK
dc.titleHigh frequency of polyoma BK virus shedding in the gastrointestinal tract after hematopoietic stem cell transplantation: A prospective and quantitative analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=43&spage=43–47&epage=&date=2008&atitle=High+frequency+of+polyoma+BK+virus+shedding+in+the+gastrointestinal+tract+after+hematopoietic+stem+cell+transplantation:+a+prospective+and+quantitative+analysisen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/bmt.2008.266en_HK
dc.identifier.pmid18836489-
dc.identifier.scopuseid_2-s2.0-58549118705en_HK
dc.identifier.hkuros157069en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58549118705&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue1en_HK
dc.identifier.spage43en_HK
dc.identifier.epage47en_HK
dc.identifier.isiWOS:000262489800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, ASY=7403144356en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.citeulike3472499-

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