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Article: Iron supplement in pregnancy and development of gestational diabetes - A randomised placebo-controlled trial

TitleIron supplement in pregnancy and development of gestational diabetes - A randomised placebo-controlled trial
Authors
KeywordsFerritin
Gestational diabetes
Impaired glucose tolerance
Iron supplement
Pregnancy
Issue Date2009
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
Bjog: An International Journal Of Obstetrics And Gynaecology, 2009, v. 116 n. 6, p. 789-797 How to Cite?
AbstractObjective To test the hypothesis that iron supplement from early pregnancy would increase the risk of gestational diabetes mellitus (GDM). Design Randomised placebo-controlled trial. Setting A university teaching hospital in Hong Kong. Population One thousand one hundred sixty-four women with singleton pregnancy at less than 16 weeks of gestation with haemoglobin (Hb) level between 8 and 14 g/dl and no pre-existing diabetes or haemoglobinopathies. Methods Women were randomly allocated to receive 60 mg of iron supplement daily (n = 565) or placebo (n = 599). Oral glucose tolerance tests (OGTTs) were performed at 28 and 36 weeks. Women were followed up until delivery. Outcome measures The primary outcome was development of GDM at 28 weeks. The secondary outcomes were 2-hour post-OGTT glucose levels, development of GDM at 36 weeks and delivery and infant outcomes. Results There was no significant difference in the incidence of GDM in the iron supplement and placebo groups at 28 weeks (OR: 1.04, 95% confidence interval [CI]: 0.7-1.53 at 90% power) or 36 weeks. Maternal Hb and ferritin levels were higher in the iron supplement group at delivery (P < 0.001 and P = 0.003, respectively). Elective caesarean section rate was lower in the iron supplement group (OR: 0.58, 95% CI: 0.37-0.89). Infant birthweight was heavier (P = 0.001), and there were fewer small-for-gestational-age babies in the iron supplement group (OR: 0.46, 95% CI: 0.24-0.85). Conclusion Iron supplement from early pregnancy does not increase the risk of GDM. It may have benefits in terms of pregnancy outcomes. © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology.
Persistent Identifierhttp://hdl.handle.net/10722/59213
ISSN
2015 Impact Factor: 4.039
2015 SCImago Journal Rankings: 2.083
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council
Funding Information:

We thank the Research Grant Council for supporting this study. We would also like to thank our research assistants Ivy Li, Lesley Lau, Theresa Cheung and Chung Him Wan for their hard work in data collection.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorChan, BCPen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLao, TTen_HK
dc.date.accessioned2010-05-31T03:45:15Z-
dc.date.available2010-05-31T03:45:15Z-
dc.date.issued2009en_HK
dc.identifier.citationBjog: An International Journal Of Obstetrics And Gynaecology, 2009, v. 116 n. 6, p. 789-797en_HK
dc.identifier.issn1470-0328en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59213-
dc.description.abstractObjective To test the hypothesis that iron supplement from early pregnancy would increase the risk of gestational diabetes mellitus (GDM). Design Randomised placebo-controlled trial. Setting A university teaching hospital in Hong Kong. Population One thousand one hundred sixty-four women with singleton pregnancy at less than 16 weeks of gestation with haemoglobin (Hb) level between 8 and 14 g/dl and no pre-existing diabetes or haemoglobinopathies. Methods Women were randomly allocated to receive 60 mg of iron supplement daily (n = 565) or placebo (n = 599). Oral glucose tolerance tests (OGTTs) were performed at 28 and 36 weeks. Women were followed up until delivery. Outcome measures The primary outcome was development of GDM at 28 weeks. The secondary outcomes were 2-hour post-OGTT glucose levels, development of GDM at 36 weeks and delivery and infant outcomes. Results There was no significant difference in the incidence of GDM in the iron supplement and placebo groups at 28 weeks (OR: 1.04, 95% confidence interval [CI]: 0.7-1.53 at 90% power) or 36 weeks. Maternal Hb and ferritin levels were higher in the iron supplement group at delivery (P < 0.001 and P = 0.003, respectively). Elective caesarean section rate was lower in the iron supplement group (OR: 0.58, 95% CI: 0.37-0.89). Infant birthweight was heavier (P = 0.001), and there were fewer small-for-gestational-age babies in the iron supplement group (OR: 0.46, 95% CI: 0.24-0.85). Conclusion Iron supplement from early pregnancy does not increase the risk of GDM. It may have benefits in terms of pregnancy outcomes. © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_HK
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecologyen_HK
dc.subjectFerritinen_HK
dc.subjectGestational diabetesen_HK
dc.subjectImpaired glucose toleranceen_HK
dc.subjectIron supplementen_HK
dc.subjectPregnancyen_HK
dc.titleIron supplement in pregnancy and development of gestational diabetes - A randomised placebo-controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, KKL: kklchan@hkucc.hku.hken_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1471-0528.2008.02014.xen_HK
dc.identifier.pmid19432567-
dc.identifier.scopuseid_2-s2.0-65349131205en_HK
dc.identifier.hkuros157339en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65349131205&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116en_HK
dc.identifier.issue6en_HK
dc.identifier.spage789en_HK
dc.identifier.epage797en_HK
dc.identifier.isiWOS:000265406900006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridChan, BCP=7201530637en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLao, TT=7005722132en_HK
dc.identifier.citeulike4404899-

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