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Article: Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores

TitleTen-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores
Authors
Issue Date2009
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2009, v. 20 n. 11, p. 1939-1945 How to Cite?
AbstractThis study estimated the 10-year probability of osteoporotic fracture in Hong Kong Southern Chinese based on a simplified model of the recently developed WHO fracture risk prediction tool (FRAX®). Thus, the data provides further insights into potential development of a population-specific FRAX® model for Hong Kong in the future. Introduction: The purpose of this paper was to estimate the 10-year probability of osteoporotic fracture in Hong Kong (HK) Southern Chinese according to age and bone mineral density (BMD) T-score at the femoral neck based on the methodology of the FRAX® risk assessment tool calibrated to the epidemiology of HK. Methods: Hip fracture data was obtained from the Clinical Data Analysis Reporting System (CDAS) of the Hospital Authority of HK and population size and death rates were taken from the HK Government Census and Statistics Department. Fracture probability was calculated using the cut-off values for T-scores derived from the NHANES III data for Caucasian women aged 20-29 years for BMD at the femoral neck. Results: In this study, the 10-year probability of osteoporotic fracture in HK Southern Chinese increased markedly with increasing age and decreasing femoral neck BMD T-scores in both women and men. Interestingly, at low T-scores, the increase in 10-year probability of osteoporotic fracture in women with age was greater than in men. Fracture probabilities were substantially higher than those from mainland China. Conclusions: Based on this evidence, and until we have HK Southern Chinese population-specific information, we recommend the application of the Caucasian risk profile to calculate the absolute fracture risk for HK Southern Chinese subjects. © 2009 International Osteoporosis Foundation and National Osteoporosis Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/59202
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong University Foundation
University of Hong Kong
Funding Information:

The authors wish to thank Ms Win Lui, Ms WM Chan, and Miss Cissy Soong for assistance in data collection. This study was supported by the Bone Health Fund of the Hong Kong University Foundation and Osteoporosis Research Fund of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorTsang, SWYen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorKanis, JAen_HK
dc.contributor.authorJohansson, Hen_HK
dc.contributor.authorOden, Aen_HK
dc.date.accessioned2010-05-31T03:45:00Z-
dc.date.available2010-05-31T03:45:00Z-
dc.date.issued2009en_HK
dc.identifier.citationOsteoporosis International, 2009, v. 20 n. 11, p. 1939-1945en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/59202-
dc.description.abstractThis study estimated the 10-year probability of osteoporotic fracture in Hong Kong Southern Chinese based on a simplified model of the recently developed WHO fracture risk prediction tool (FRAX®). Thus, the data provides further insights into potential development of a population-specific FRAX® model for Hong Kong in the future. Introduction: The purpose of this paper was to estimate the 10-year probability of osteoporotic fracture in Hong Kong (HK) Southern Chinese according to age and bone mineral density (BMD) T-score at the femoral neck based on the methodology of the FRAX® risk assessment tool calibrated to the epidemiology of HK. Methods: Hip fracture data was obtained from the Clinical Data Analysis Reporting System (CDAS) of the Hospital Authority of HK and population size and death rates were taken from the HK Government Census and Statistics Department. Fracture probability was calculated using the cut-off values for T-scores derived from the NHANES III data for Caucasian women aged 20-29 years for BMD at the femoral neck. Results: In this study, the 10-year probability of osteoporotic fracture in HK Southern Chinese increased markedly with increasing age and decreasing femoral neck BMD T-scores in both women and men. Interestingly, at low T-scores, the increase in 10-year probability of osteoporotic fracture in women with age was greater than in men. Fracture probabilities were substantially higher than those from mainland China. Conclusions: Based on this evidence, and until we have HK Southern Chinese population-specific information, we recommend the application of the Caucasian risk profile to calculate the absolute fracture risk for HK Southern Chinese subjects. © 2009 International Osteoporosis Foundation and National Osteoporosis Foundation.en_HK
dc.languageengen_HK
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.subject.meshAge Distributionen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBone Density - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFemur Neck - physiopathologyen_HK
dc.subject.meshHip Fractures - ethnology - physiopathologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsteoporotic Fractures - ethnology - physiopathologyen_HK
dc.subject.meshRisk Assessment - methodsen_HK
dc.subject.meshSex Distributionen_HK
dc.titleTen-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scoresen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-2965&volume=DOI 10.1007/s00198-009-0906-1&spage=&epage=&date=2009&atitle=Ten-Year+Fracture+Probability+in+Hong+Kong+Southern+Chinese+According+to+Age+and+BMD+Femoral+Neck+T-Scoresen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00198-009-0906-1en_HK
dc.identifier.pmid19326036-
dc.identifier.scopuseid_2-s2.0-76449109982en_HK
dc.identifier.hkuros160986en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76449109982&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1939en_HK
dc.identifier.epage1945en_HK
dc.identifier.isiWOS:000271028200016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsang, SWY=35182014900en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridKanis, JA=7102759272en_HK
dc.identifier.scopusauthoridJohansson, H=23027246200en_HK
dc.identifier.scopusauthoridOden, A=7005252727en_HK
dc.identifier.citeulike4261803-

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