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Article: Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus

TitleSoluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus
Authors
Issue Date2008
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/
Citation
Journal Of Lipid Research, 2008, v. 49 n. 7, p. 1438-1444 How to Cite?
AbstractThe lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) can be proteolytically cleaved and released as soluble forms (sLOX-1). We have determined serum sLOX-1 in type 2 diabetes and evaluated the effect of glucose and advanced glycation end products (AGEs) on sLOX-1 in vitro and in vivo. Endothelial cells were incubated with glucose or AGEs, and sLOX-1 in cell medium was measured. Serum sLOX-1 was measured in 219 diabetic patients and 187 controls by ELISA. The effect of lowering glucose and AGEs on sLOX-1 was determined in 38 poorly controlled diabetic patients after improvement in glycemic control. Incubation of endothelial cells with AGE-BSA led to a dosedependent increase in sLOX-1, whereas the effect of glucose on sLOX-1 was less marked. Serum sLOX-1 was 9% higher in diabetic patients compared with controls (P < 0.01). In the poorly controlled patients, serum sLOX-1 decreased by 12.5% after improvement in glycemic control (P < 0.05). The magnitude of reduction in sLOX-1 correlated with the improvement in hemoglobin A1c and AGEs but not with the reduction in oxidized LDL. sLOX-1 level is increased in type 2 diabetes. Both glucose and AGEs are important determinants of LOX-1 expression, and lowering glucose and AGEs leads to a reduction in sLOX-1. Copyright © 2008 by the American Society for Biochemistry and Molecular Biology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59195
ISSN
2015 Impact Factor: 4.368
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorLeng, Len_HK
dc.contributor.authorBucala, Ren_HK
dc.date.accessioned2010-05-31T03:44:50Z-
dc.date.available2010-05-31T03:44:50Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Lipid Research, 2008, v. 49 n. 7, p. 1438-1444en_HK
dc.identifier.issn0022-2275en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59195-
dc.description.abstractThe lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) can be proteolytically cleaved and released as soluble forms (sLOX-1). We have determined serum sLOX-1 in type 2 diabetes and evaluated the effect of glucose and advanced glycation end products (AGEs) on sLOX-1 in vitro and in vivo. Endothelial cells were incubated with glucose or AGEs, and sLOX-1 in cell medium was measured. Serum sLOX-1 was measured in 219 diabetic patients and 187 controls by ELISA. The effect of lowering glucose and AGEs on sLOX-1 was determined in 38 poorly controlled diabetic patients after improvement in glycemic control. Incubation of endothelial cells with AGE-BSA led to a dosedependent increase in sLOX-1, whereas the effect of glucose on sLOX-1 was less marked. Serum sLOX-1 was 9% higher in diabetic patients compared with controls (P < 0.01). In the poorly controlled patients, serum sLOX-1 decreased by 12.5% after improvement in glycemic control (P < 0.05). The magnitude of reduction in sLOX-1 correlated with the improvement in hemoglobin A1c and AGEs but not with the reduction in oxidized LDL. sLOX-1 level is increased in type 2 diabetes. Both glucose and AGEs are important determinants of LOX-1 expression, and lowering glucose and AGEs leads to a reduction in sLOX-1. Copyright © 2008 by the American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/en_HK
dc.relation.ispartofJournal of Lipid Researchen_HK
dc.rightsJournal of Lipid Research. Copyright © American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshScavenger Receptors, Class E - blooden_HK
dc.subject.meshSolubilityen_HK
dc.titleSoluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2275&volume=49&spage=1438&epage=44&date=2008&atitle=Soluble+lectin-like+oxidized+low+density+lipoprotein+receptor-1+in+type+2+diabetes+mellitusen_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1194/jlr.M700551-JLR200en_HK
dc.identifier.pmid18408244en_HK
dc.identifier.scopuseid_2-s2.0-50949106121en_HK
dc.identifier.hkuros145705en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50949106121&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1438en_HK
dc.identifier.epage1444en_HK
dc.identifier.eissn1539-7262-
dc.identifier.isiWOS:000256720300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridWong, Y=24073787400en_HK
dc.identifier.scopusauthoridLeng, L=7006089148en_HK
dc.identifier.scopusauthoridBucala, R=7102379822en_HK

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