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Article: Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation

TitleInteratrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation
Authors
KeywordsAtrial contraction velocity
Inter- or intraatrial synchronicity
Paroxysmal atrial fibrillation
Sinus node disease
Tissue Doppler imaging
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 11, p. 1237-1243 How to Cite?
AbstractAtrial Mechanical Dyssynchrony in Sinus Node Disease.Introduction: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. Methods: We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual-chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septallateralinferioranteriorposterioranterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. Results: There were no differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 ± 19 vs 91 ± 17 cms, P = 0.005), LA active empting fraction (24 ± 14 vs 36 ± 13%, P = 0.027), mean Va of LA (2.6 ± 0.9 vs 3.4 ± 0.9 cms, P = 0.028), and greater interatrial synchronicity (33 ± 25 vs 12 ± 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR] = 1.12, 95% Confidence interval [CI] 1.01-1.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01-1.16, P = 0.020) were independent predictors for the presence of AF in SND patients. Conclusion: SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients. © 2009 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59191
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
Funding AgencyGrant Number
General Research Fund of Research Grant Council of Hong KongHKU 7777/07M
HKU 7775/08M
Funding Information:

This study was supported by General Research Fund of Research Grant Council of Hong Kong (HKU 7777/07M and HKU 7775/08M).

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorZhang, XHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLee, KLFen_HK
dc.contributor.authorYan, GHen_HK
dc.contributor.authorYue, WSen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-05-31T03:44:44Z-
dc.date.available2010-05-31T03:44:44Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2009, v. 20 n. 11, p. 1237-1243en_HK
dc.identifier.issn1045-3873en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59191-
dc.description.abstractAtrial Mechanical Dyssynchrony in Sinus Node Disease.Introduction: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. Methods: We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual-chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septallateralinferioranteriorposterioranterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. Results: There were no differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 ± 19 vs 91 ± 17 cms, P = 0.005), LA active empting fraction (24 ± 14 vs 36 ± 13%, P = 0.027), mean Va of LA (2.6 ± 0.9 vs 3.4 ± 0.9 cms, P = 0.028), and greater interatrial synchronicity (33 ± 25 vs 12 ± 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR] = 1.12, 95% Confidence interval [CI] 1.01-1.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01-1.16, P = 0.020) were independent predictors for the presence of AF in SND patients. Conclusion: SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients. © 2009 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_HK
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectAtrial contraction velocityen_HK
dc.subjectInter- or intraatrial synchronicityen_HK
dc.subjectParoxysmal atrial fibrillationen_HK
dc.subjectSinus node diseaseen_HK
dc.subjectTissue Doppler imagingen_HK
dc.subject.meshAged-
dc.subject.meshArrhythmia, Sinus - diagnosis - epidemiology-
dc.subject.meshAtrial Fibrillation - diagnosis - epidemiology-
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshVentricular Dysfunction, Left - diagnosis - epidemiology-
dc.titleInteratrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-3873&volume=20&issue=11&spage=1237–1243&epage=&date=2009&atitle=Interatrial+mechanical+dyssynchrony+worsened+atrial+mechanical+function+in+sinus+node+disease+with+or+without+paroxysmal+atrial+fibrillationen_HK
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00281en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8167.2009.01547.xen_HK
dc.identifier.pmid19602020-
dc.identifier.scopuseid_2-s2.0-70350616528en_HK
dc.identifier.hkuros155823en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350616528&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1237en_HK
dc.identifier.epage1243en_HK
dc.identifier.isiWOS:000271416700009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, M=7406690398en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridZhang, XH=16425051500en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLee, KLF=8624893900en_HK
dc.identifier.scopusauthoridYan, GH=36544693600en_HK
dc.identifier.scopusauthoridYue, WS=36106565300en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike6177469-

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