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Article: Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese

TitleMultiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese
Authors
KeywordsAssociation
BMD
Candidate gene
Interaction
Osteoporosis
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone
Citation
Bone, 2009, v. 44 n. 5, p. 984-988 How to Cite?
AbstractIntroduction: Chromosome 1p36 is a region that has previously shown good evidence of linkage to bone mineral density (BMD) in multiple studies, but the genes that are responsible for the linkage signals are unknown. Materials and methods: We performed a gene-wide and tag SNP-based association study of four positional and functional candidate genes (TNFRSF1B, PLOD, CNR2, and MTHFR) at 1p36 in 1, 243 case-control Chinese subjects. Twenty-three tag SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Binary logistic regression analyses were performed to test for genotype associations between each SNP and BMD. Allelic and haplotype association analyses were conducted by Haploview. Gene-gene interactions were investigated using multifactor dimensionality reduction method. Results: The PLOD rs7529452 (C385T; F98F) and MTHFR rs1801133 (C677T; A429E) showed significant genotypic/allelic associations with BMDs at all sites measured (P = 0.08-0.001), and a promising two-locus gene-gene interaction for femoral neck BMD. The CNR2 rs2501431 (A592G; G155G) showed nominally significant allelic associations with trochanter and hip BMD. The TNFRSF1B rs976881 showed genotypic associations with BMDs (P = 0.08-0.04). Conclusions: Our results suggest that multiple genes at 1p36, individually or in different combinations, contribute to osteoporosis susceptibility in Chinese. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59180
ISSN
2015 Impact Factor: 3.736
2015 SCImago Journal Rankings: 1.752
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant Council
The University of Hong Kong
Bone Health Fund
Hong Kong University Foundation
Matching Grant
Osteoporosis and Endocrine Research Fund
The KC Wong Education Foundation
Funding Information:

This project is supported by Hong Kong Research Grant Council and seed funding for basic research, The University of Hong Kong, the Bone Health Fund, Hong Kong University Foundation, Matching Grant and the Osteoporosis and Endocrine Research Fund, The University of Hong Kong. QY Huang is partially supported by The KC Wong Education Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorLi, GHYen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-05-31T03:44:26Z-
dc.date.available2010-05-31T03:44:26Z-
dc.date.issued2009en_HK
dc.identifier.citationBone, 2009, v. 44 n. 5, p. 984-988en_HK
dc.identifier.issn8756-3282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59180-
dc.description.abstractIntroduction: Chromosome 1p36 is a region that has previously shown good evidence of linkage to bone mineral density (BMD) in multiple studies, but the genes that are responsible for the linkage signals are unknown. Materials and methods: We performed a gene-wide and tag SNP-based association study of four positional and functional candidate genes (TNFRSF1B, PLOD, CNR2, and MTHFR) at 1p36 in 1, 243 case-control Chinese subjects. Twenty-three tag SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Binary logistic regression analyses were performed to test for genotype associations between each SNP and BMD. Allelic and haplotype association analyses were conducted by Haploview. Gene-gene interactions were investigated using multifactor dimensionality reduction method. Results: The PLOD rs7529452 (C385T; F98F) and MTHFR rs1801133 (C677T; A429E) showed significant genotypic/allelic associations with BMDs at all sites measured (P = 0.08-0.001), and a promising two-locus gene-gene interaction for femoral neck BMD. The CNR2 rs2501431 (A592G; G155G) showed nominally significant allelic associations with trochanter and hip BMD. The TNFRSF1B rs976881 showed genotypic associations with BMDs (P = 0.08-0.04). Conclusions: Our results suggest that multiple genes at 1p36, individually or in different combinations, contribute to osteoporosis susceptibility in Chinese. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/boneen_HK
dc.relation.ispartofBoneen_HK
dc.rightsBone. Copyright © Elsevier Inc.en_HK
dc.subjectAssociationen_HK
dc.subjectBMDen_HK
dc.subjectCandidate geneen_HK
dc.subjectInteractionen_HK
dc.subjectOsteoporosisen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 1 - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenetic Predisposition to Disease - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethylenetetrahydrofolate Reductase (NADPH2) - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOsteoporosis - geneticsen_HK
dc.subject.meshPolymorphism, Single Nucleotide - geneticsen_HK
dc.subject.meshProcollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - geneticsen_HK
dc.subject.meshReceptors, Cannabinoid - geneticsen_HK
dc.subject.meshReceptors, Tumor Necrosis Factor, Type II - geneticsen_HK
dc.titleMultiple osteoporosis susceptibility genes on chromosome 1p36 in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=8756-3282&volume=44&issue=5&spage=984&epage=988&date=2009&atitle=Multiple+osteoporosis+susceptibility+genes+on+chromosome+1p36+in+Chineseen_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bone.2009.01.368en_HK
dc.identifier.pmid19442614-
dc.identifier.scopuseid_2-s2.0-63649101425en_HK
dc.identifier.hkuros155799en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63649101425&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue5en_HK
dc.identifier.spage984en_HK
dc.identifier.epage988en_HK
dc.identifier.isiWOS:000265436000035-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridLi, GHY=35080710200en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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