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Article: Cellular cholesterol efflux to serum is impaired in diabetic nephropathy

TitleCellular cholesterol efflux to serum is impaired in diabetic nephropathy
Authors
Issue Date2008
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394
Citation
Diabetes/Metabolism Research And Reviews, 2008, v. 24 n. 8, p. 617-623 How to Cite?
AbstractBackground: Cholesterol efflux from cells is an early step of reverse cholesterol transport (RCT) and the capacity of serum to induce cellular cholesterol efflux has recently been shown to be an independent predictor of coronary artery atherosclerosis. Our aim is to evaluate the capacity of serum to induce ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) mediated cholesterol efflux in type 2 diabetic patients with nephropathy. Methods: Diabetic patients were recruited according to their urinary albumin excretion rate (normoalbuminuria, microalbuminuria and proteinuria) with 20 subjects in each group and compared with 20 age-matched controls. The ability of the serum to induce cholesterol efflux was measured using a cell culture system. Results: Serum capacity to induce ABCA1-mediated cholesterol efflux was decreased in patients with microalbuminuria or proteinuria (p < 0.05) whereas SR-BI-mediated cholesterol efflux was impaired in all three groups of diabetic patients (p < 0.05). Plasma high-density lipoprotein (HDL) cholesterol and apoAI were reduced in all groups of diabetic patients, but pre-β-HDL was only significantly decreased in those with microalbuminuria or proteinuria. Serum advanced glycation end products (AGEs) were significantly increased in diabetic patients with microalbuminuria or proteinuria. Serum AGEs and pre-β-HDL were the significant independent determinants of ABCA1-mediated cholesterol efflux, whereas plasma HDL and log (creatinine) were the significant determinants of SR-BI-mediated cholesterol efflux. Conclusion: The capacity of serum to induce ABCA1- and SR-BI-mediated cholesterol efflux was impaired in diabetic patients with incipient or overt nephropathy. These abnormalities may contribute to the accelerated development of atherosclerotic vascular disease in these patients. Copyright © 2008 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59178
ISSN
2012 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.617
ISI Accession Number ID
Funding AgencyGrant Number
Committee on Research and Conference Grants of the University of Hong Kong
Funding Information:

This study is supported by a grant from the Committee on Research and Conference Grants of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.date.accessioned2010-05-31T03:44:24Z-
dc.date.available2010-05-31T03:44:24Z-
dc.date.issued2008en_HK
dc.identifier.citationDiabetes/Metabolism Research And Reviews, 2008, v. 24 n. 8, p. 617-623en_HK
dc.identifier.issn1520-7552en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59178-
dc.description.abstractBackground: Cholesterol efflux from cells is an early step of reverse cholesterol transport (RCT) and the capacity of serum to induce cellular cholesterol efflux has recently been shown to be an independent predictor of coronary artery atherosclerosis. Our aim is to evaluate the capacity of serum to induce ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) mediated cholesterol efflux in type 2 diabetic patients with nephropathy. Methods: Diabetic patients were recruited according to their urinary albumin excretion rate (normoalbuminuria, microalbuminuria and proteinuria) with 20 subjects in each group and compared with 20 age-matched controls. The ability of the serum to induce cholesterol efflux was measured using a cell culture system. Results: Serum capacity to induce ABCA1-mediated cholesterol efflux was decreased in patients with microalbuminuria or proteinuria (p < 0.05) whereas SR-BI-mediated cholesterol efflux was impaired in all three groups of diabetic patients (p < 0.05). Plasma high-density lipoprotein (HDL) cholesterol and apoAI were reduced in all groups of diabetic patients, but pre-β-HDL was only significantly decreased in those with microalbuminuria or proteinuria. Serum advanced glycation end products (AGEs) were significantly increased in diabetic patients with microalbuminuria or proteinuria. Serum AGEs and pre-β-HDL were the significant independent determinants of ABCA1-mediated cholesterol efflux, whereas plasma HDL and log (creatinine) were the significant determinants of SR-BI-mediated cholesterol efflux. Conclusion: The capacity of serum to induce ABCA1- and SR-BI-mediated cholesterol efflux was impaired in diabetic patients with incipient or overt nephropathy. These abnormalities may contribute to the accelerated development of atherosclerotic vascular disease in these patients. Copyright © 2008 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394en_HK
dc.relation.ispartofDiabetes/Metabolism Research and Reviewsen_HK
dc.subject.meshATP-Binding Cassette Transporters - blood - genetics - metabolismen_HK
dc.subject.meshAlbuminuria - blood - metabolismen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshBiological Transporten_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshCholesterol - blood - metabolismen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - blood - metabolismen_HK
dc.subject.meshDiabetic Nephropathies - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemoglobin A, Glycosylated - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLipids - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProteinuria - blood - metabolismen_HK
dc.subject.meshRNA, Messenger - geneticsen_HK
dc.subject.meshScavenger Receptors, Class B - blood - metabolismen_HK
dc.titleCellular cholesterol efflux to serum is impaired in diabetic nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/dmrr.895en_HK
dc.identifier.pmid18802933-
dc.identifier.scopuseid_2-s2.0-60849115896en_HK
dc.identifier.hkuros158328en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60849115896&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue8en_HK
dc.identifier.spage617en_HK
dc.identifier.epage623en_HK
dc.identifier.isiWOS:000261302800004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhou, H=24077909100en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridWong, Y=24073787400en_HK

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