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Article: Alterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia

TitleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
Authors
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002 How to Cite?
AbstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/59176
ISSN
2014 Impact Factor: 2.613
2014 SCImago Journal Rankings: 0.904
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Sen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorMa, Jen_HK
dc.contributor.authorChen, Men_HK
dc.contributor.authorHu, Pen_HK
dc.contributor.authorGu, Qen_HK
dc.contributor.authorLiang, Yen_HK
dc.contributor.authorLin, Hen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-05-31T03:44:22Z-
dc.date.available2010-05-31T03:44:22Z-
dc.date.issued2009en_HK
dc.identifier.citationDigestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002en_HK
dc.identifier.issn0163-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59176-
dc.description.abstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_HK
dc.relation.ispartofDigestive Diseases and Sciencesen_HK
dc.subject.meshAdulten_HK
dc.subject.meshDyspepsia - metabolism - microbiology - pathologyen_HK
dc.subject.meshEye Proteins - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastric Mucosa - chemistry - microbiologyen_HK
dc.subject.meshGastroscopyen_HK
dc.subject.meshHelicobacter Infections - metabolism - microbiology - pathologyen_HK
dc.subject.meshHelicobacter pylori - isolation & purificationen_HK
dc.subject.meshHomeodomain Proteins - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetaplasiaen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPaired Box Transcription Factors - analysisen_HK
dc.subject.meshPyloric Antrum - chemistry - microbiologyen_HK
dc.subject.meshRepressor Proteins - analysisen_HK
dc.subject.meshStomach - chemistry - microbiology - pathologyen_HK
dc.subject.meshTrans-Activators - analysisen_HK
dc.titleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasiaen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10620-008-0459-8en_HK
dc.identifier.pmid18754095en_HK
dc.identifier.scopuseid_2-s2.0-64049114354en_HK
dc.identifier.hkuros158982en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64049114354&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue5en_HK
dc.identifier.spage996en_HK
dc.identifier.epage1002en_HK
dc.identifier.isiWOS:000264810100011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhu, S=7404391208en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridYang, Y=8675011000en_HK
dc.identifier.scopusauthoridMa, J=35275386200en_HK
dc.identifier.scopusauthoridChen, M=8642044500en_HK
dc.identifier.scopusauthoridHu, P=7201989582en_HK
dc.identifier.scopusauthoridGu, Q=24469982400en_HK
dc.identifier.scopusauthoridLiang, Y=12804573800en_HK
dc.identifier.scopusauthoridLin, H=8950219500en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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