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Article: Alterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
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TitleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
 
AuthorsZhu, S2 1
Xia, HHX1 3
Yang, Y1
Ma, J2 1
Chen, M2
Hu, P2
Gu, Q1
Liang, Y2
Lin, H2
Wong, BCY1
 
Issue Date2009
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
 
CitationDigestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10620-008-0459-8
 
AbstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.
 
ISSN0163-2116
2013 Impact Factor: 2.550
 
DOIhttp://dx.doi.org/10.1007/s10620-008-0459-8
 
ISI Accession Number IDWOS:000264810100011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, S
 
dc.contributor.authorXia, HHX
 
dc.contributor.authorYang, Y
 
dc.contributor.authorMa, J
 
dc.contributor.authorChen, M
 
dc.contributor.authorHu, P
 
dc.contributor.authorGu, Q
 
dc.contributor.authorLiang, Y
 
dc.contributor.authorLin, H
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2010-05-31T03:44:22Z
 
dc.date.available2010-05-31T03:44:22Z
 
dc.date.issued2009
 
dc.description.abstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDigestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10620-008-0459-8
 
dc.identifier.doihttp://dx.doi.org/10.1007/s10620-008-0459-8
 
dc.identifier.epage1002
 
dc.identifier.hkuros158982
 
dc.identifier.isiWOS:000264810100011
 
dc.identifier.issn0163-2116
2013 Impact Factor: 2.550
 
dc.identifier.issue5
 
dc.identifier.pmid18754095
 
dc.identifier.scopuseid_2-s2.0-64049114354
 
dc.identifier.spage996
 
dc.identifier.urihttp://hdl.handle.net/10722/59176
 
dc.identifier.volume54
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDigestive Diseases and Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshDyspepsia - metabolism - microbiology - pathology
 
dc.subject.meshEye Proteins - analysis
 
dc.subject.meshFemale
 
dc.subject.meshGastric Mucosa - chemistry - microbiology
 
dc.subject.meshGastroscopy
 
dc.subject.meshHelicobacter Infections - metabolism - microbiology - pathology
 
dc.subject.meshHelicobacter pylori - isolation & purification
 
dc.subject.meshHomeodomain Proteins - analysis
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshMale
 
dc.subject.meshMetaplasia
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPaired Box Transcription Factors - analysis
 
dc.subject.meshPyloric Antrum - chemistry - microbiology
 
dc.subject.meshRepressor Proteins - analysis
 
dc.subject.meshStomach - chemistry - microbiology - pathology
 
dc.subject.meshTrans-Activators - analysis
 
dc.titleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
 
dc.typeArticle
 
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<contributor.author>Ma, J</contributor.author>
<contributor.author>Chen, M</contributor.author>
<contributor.author>Hu, P</contributor.author>
<contributor.author>Gu, Q</contributor.author>
<contributor.author>Liang, Y</contributor.author>
<contributor.author>Lin, H</contributor.author>
<contributor.author>Wong, BCY</contributor.author>
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<description.abstract>Purpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P &lt; 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P &lt; 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P &lt; 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. &#169; 2008 Springer Science+Business Media, LLC.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. Novartis Pharma