Article: Alterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia

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TitleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
AuthorsZhu, S1 2
Xia, HHX1 3
Yang, Y1
Ma, J1 2
Chen, M2
Hu, P2
Gu, Q1
Liang, Y2
Lin, H2
Wong, BCY1
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
CitationDigestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10620-008-0459-8
AbstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.
ISSN0163-2116
2011 Impact Factor: 2.117
2011 SCImago Journal Rankings: 0.187
DOIhttp://dx.doi.org/10.1007/s10620-008-0459-8
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhu, S
dc.contributor.authorXia, HHX
dc.contributor.authorYang, Y
dc.contributor.authorMa, J
dc.contributor.authorChen, M
dc.contributor.authorHu, P
dc.contributor.authorGu, Q
dc.contributor.authorLiang, Y
dc.contributor.authorLin, H
dc.contributor.authorWong, BCY
dc.date.accessioned2010-05-31T03:44:22Z
dc.date.available2010-05-31T03:44:22Z
dc.date.issued2009
dc.description.abstractPurpose This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM). Methods Gastric biopsy specimens were taken from 98 patients with non-ulcer dyspepsia for the detection of H. pylori infection; histological examinations; immunohistochemical staining of CDX2, PDX1, PAX6, and NKX6.1. Results Of the patients, 38 were positive for H. pylori infection, 44 had antral-type mucosa at the incisura, and 22 had IM in the stomach. At the incisura, the expression of PDX1, NKX6.1, and PAX6 in cytoplasm compartment was down-regulated in antral-type mucosa compared with that in the transitional- or body-type mucosa (all P < 0.01). The expression of PDX1, PAX6, and NKX6.1 in cytoplasm at the incisura was down-regulated in H. pylori-infected patients compared with that in those without H. pylori infection (all P < 0.01). CDX2 expression in whole stomach was up-regulated, but PDX1 expression at the incisura was down-regulated in patients with IM compared with that in those without IM (all P < 0.01). Conclusions Gastric expression of PDX1, PAX 6, and NKX6.1 is down-regulated in H. pylori infection and incisural antralisation. CDX2 is up-regulated but PDX1 is down-regulated in the presence of IM. © 2008 Springer Science+Business Media, LLC.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDigestive Diseases And Sciences, 2009, v. 54 n. 5, p. 996-1002 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10620-008-0459-8
dc.identifier.doihttp://dx.doi.org/10.1007/s10620-008-0459-8
dc.identifier.epage1002
dc.identifier.hkuros158982
dc.identifier.isiWOS:000264810100011
dc.identifier.issn0163-2116
2011 Impact Factor: 2.117
2011 SCImago Journal Rankings: 0.187
dc.identifier.issue5
dc.identifier.pmid18754095
dc.identifier.scopuseid_2-s2.0-64049114354
dc.identifier.spage996
dc.identifier.urihttp://hdl.handle.net/10722/59176
dc.identifier.volume54
dc.languageeng
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
dc.publisher.placeUnited States
dc.relation.ispartofDigestive Diseases and Sciences
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshDyspepsia - metabolism - microbiology - pathology
dc.subject.meshEye Proteins - analysis
dc.subject.meshFemale
dc.subject.meshGastric Mucosa - chemistry - microbiology
dc.subject.meshGastroscopy
dc.subject.meshHelicobacter Infections - metabolism - microbiology - pathology
dc.subject.meshHelicobacter pylori - isolation & purification
dc.subject.meshHomeodomain Proteins - analysis
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMetaplasia
dc.subject.meshMiddle Aged
dc.subject.meshPaired Box Transcription Factors - analysis
dc.subject.meshPyloric Antrum - chemistry - microbiology
dc.subject.meshRepressor Proteins - analysis
dc.subject.meshStomach - chemistry - microbiology - pathology
dc.subject.meshTrans-Activators - analysis
dc.titleAlterations of gastric homeoprotein expression in helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. Novartis Pharma