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Article: Obstructive sleep apnea and the metabolic syndrome

TitleObstructive sleep apnea and the metabolic syndrome
Authors
KeywordsGlucose metabolism
Hypertension
Metabolic syndrome
Obstructive sleep apnea
Issue Date2009
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/page/journal/ers/teaser
Citation
Expert Review Of Respiratory Medicine, 2009, v. 3 n. 2, p. 177-186 How to Cite?
Abstract
Obstructive sleep apnea (OSA) and the metabolic syndrome have a strong association with each other owing to their common feature of obesity, but an association independent of obesity has been demonstrated in several studies. There is also evidence, of varying strengths, from epidemiologic and clinical studies, for the independent association between OSA and individual core components of the metabolic syndrome, including hypertension, insulin resistance and dyslipidemia. To date, the data are strongest for hypertension, while data for adverse glucose or lipid metabolism are more controversial. Obesity and other factors, such as alcohol drinking and smoking, obviously pose major confounding hurdles to the clarification of the causal or aggravational role of OSA on cardiometabolic risks. Recurrent episodes of obstructed breathing notably result in intermittent hypoxemia and sleep fragmentation, and these may in turn lead to many adverse body responses, including sympathetic activation, neurohumeral changes and inflammation, which are the seeds for cardiometabolic dysfunctions, such as atherosclerosis and diabetes mellitus. Evidence from translational studies or animal/cell work are forthcoming in the delineation of these pathogenetic mechanisms. © 2009 Expert Reviews Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59173
ISSN
2013 SCImago Journal Rankings: 0.862
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-05-31T03:44:18Z-
dc.date.available2010-05-31T03:44:18Z-
dc.date.issued2009en_HK
dc.identifier.citationExpert Review Of Respiratory Medicine, 2009, v. 3 n. 2, p. 177-186en_HK
dc.identifier.issn1747-6348en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59173-
dc.description.abstractObstructive sleep apnea (OSA) and the metabolic syndrome have a strong association with each other owing to their common feature of obesity, but an association independent of obesity has been demonstrated in several studies. There is also evidence, of varying strengths, from epidemiologic and clinical studies, for the independent association between OSA and individual core components of the metabolic syndrome, including hypertension, insulin resistance and dyslipidemia. To date, the data are strongest for hypertension, while data for adverse glucose or lipid metabolism are more controversial. Obesity and other factors, such as alcohol drinking and smoking, obviously pose major confounding hurdles to the clarification of the causal or aggravational role of OSA on cardiometabolic risks. Recurrent episodes of obstructed breathing notably result in intermittent hypoxemia and sleep fragmentation, and these may in turn lead to many adverse body responses, including sympathetic activation, neurohumeral changes and inflammation, which are the seeds for cardiometabolic dysfunctions, such as atherosclerosis and diabetes mellitus. Evidence from translational studies or animal/cell work are forthcoming in the delineation of these pathogenetic mechanisms. © 2009 Expert Reviews Ltd.en_HK
dc.languageengen_HK
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/page/journal/ers/teaseren_HK
dc.relation.ispartofExpert Review of Respiratory Medicineen_HK
dc.subjectGlucose metabolismen_HK
dc.subjectHypertensionen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectObstructive sleep apneaen_HK
dc.titleObstructive sleep apnea and the metabolic syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1747-6348&volume=3&spage=177&epage=186&date=2009&atitle=Obstructive+sleep+apnea+and+the+metabolic+syndrome+en_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/ers.09.10en_HK
dc.identifier.scopuseid_2-s2.0-69949154199en_HK
dc.identifier.hkuros162715en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69949154199&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue2en_HK
dc.identifier.spage177en_HK
dc.identifier.epage186en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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