File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm

TitleA unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm
Authors
KeywordsCD4/CD56
Masquerade
Plasmacytoid dendritic cell tumor
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2009, v. 50 n. 6, p. 932-936 How to Cite?
AbstractA patient with history of B cell lymphoma treated with rituximab-based chemotherapy relapsed with a blastic CD4+/CD56+ neoplasm that was negative for CD20, CD79a and CD3. The relapse morphology and immunophenotyping were unusual and plasmacytoid dendritic cell (PDC) tumor enters the differential diagnosis. However, expressions of Oct-2 and CD10 in the relapse tumor were both more compatible with B cell than PDC lineage. Molecular investigations showed clonal rearrangements for both immunoglobulin heavy chain (IgH) and T cell receptor (TCR) γ chain gene by polymerase chain reaction (PCR). Furthermore, a clonal relationship with the original B cell lymphoma was demonstrated for all PCR products. Our case illustrated the potential pitfalls and ambiguity of lineage classification based on morphology and immunophenotyping alone, especially for rare and poorly defined entities.
Persistent Identifierhttp://hdl.handle.net/10722/59159
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorWong, KYen_HK
dc.contributor.authorWan, TSen_HK
dc.contributor.authorSo, JCen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-05-31T03:44:01Z-
dc.date.available2010-05-31T03:44:01Z-
dc.date.issued2009en_HK
dc.identifier.citationLeukemia And Lymphoma, 2009, v. 50 n. 6, p. 932-936en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59159-
dc.description.abstractA patient with history of B cell lymphoma treated with rituximab-based chemotherapy relapsed with a blastic CD4+/CD56+ neoplasm that was negative for CD20, CD79a and CD3. The relapse morphology and immunophenotyping were unusual and plasmacytoid dendritic cell (PDC) tumor enters the differential diagnosis. However, expressions of Oct-2 and CD10 in the relapse tumor were both more compatible with B cell than PDC lineage. Molecular investigations showed clonal rearrangements for both immunoglobulin heavy chain (IgH) and T cell receptor (TCR) γ chain gene by polymerase chain reaction (PCR). Furthermore, a clonal relationship with the original B cell lymphoma was demonstrated for all PCR products. Our case illustrated the potential pitfalls and ambiguity of lineage classification based on morphology and immunophenotyping alone, especially for rare and poorly defined entities.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subjectCD4/CD56en_HK
dc.subjectMasqueradeen_HK
dc.subjectPlasmacytoid dendritic cell tumoren_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntigens, CD20 - analysisen_HK
dc.subject.meshAntigens, CD4 - analysisen_HK
dc.subject.meshAntigens, CD56 - analysisen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshDendritic Cells - metabolism - pathologyen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulin Heavy Chains - geneticsen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLymphoma, B-Cell - genetics - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshNeoplasm Recurrence, Localen_HK
dc.subject.meshNeoplastic Stem Cells - metabolism - pathologyen_HK
dc.subject.meshOctamer Transcription Factor-2 - analysisen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshReceptors, Antigen, T-Cell, gamma-delta - geneticsen_HK
dc.subject.meshSequence Homology, Nucleic Aciden_HK
dc.titleA unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasmen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=50&issue=6&spage=932&epage=6&date=2009&atitle=A+unique+case+of+B+cell+lymphoma+relapsing+as+CD4/CD56+blastic+neoplasmen_HK
dc.identifier.emailSo, JC:scc@pathology.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authoritySo, JC=rp00391en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/10428190902878463en_HK
dc.identifier.pmid19504395-
dc.identifier.scopuseid_2-s2.0-68449101744en_HK
dc.identifier.hkuros159740en_HK
dc.identifier.hkuros180718-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68449101744&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue6en_HK
dc.identifier.spage932en_HK
dc.identifier.epage936en_HK
dc.identifier.isiWOS:000266810900014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridWong, KY=7404758500en_HK
dc.identifier.scopusauthoridWan, TS=25623981600en_HK
dc.identifier.scopusauthoridSo, JC=7102919978en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats