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- Publisher Website: 10.1080/10428190902878463
- Scopus: eid_2-s2.0-68449101744
- PMID: 19504395
- WOS: WOS:000266810900014
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Article: A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm
Title | A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm |
---|---|
Authors | |
Keywords | CD4/CD56 Masquerade Plasmacytoid dendritic cell tumor |
Issue Date | 2009 |
Publisher | Informa Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal |
Citation | Leukemia And Lymphoma, 2009, v. 50 n. 6, p. 932-936 How to Cite? |
Abstract | A patient with history of B cell lymphoma treated with rituximab-based chemotherapy relapsed with a blastic CD4+/CD56+ neoplasm that was negative for CD20, CD79a and CD3. The relapse morphology and immunophenotyping were unusual and plasmacytoid dendritic cell (PDC) tumor enters the differential diagnosis. However, expressions of Oct-2 and CD10 in the relapse tumor were both more compatible with B cell than PDC lineage. Molecular investigations showed clonal rearrangements for both immunoglobulin heavy chain (IgH) and T cell receptor (TCR) γ chain gene by polymerase chain reaction (PCR). Furthermore, a clonal relationship with the original B cell lymphoma was demonstrated for all PCR products. Our case illustrated the potential pitfalls and ambiguity of lineage classification based on morphology and immunophenotyping alone, especially for rare and poorly defined entities. |
Persistent Identifier | http://hdl.handle.net/10722/59159 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.790 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Au, WY | en_HK |
dc.contributor.author | Wong, KY | en_HK |
dc.contributor.author | Wan, TS | en_HK |
dc.contributor.author | So, JC | en_HK |
dc.contributor.author | Srivastava, G | en_HK |
dc.contributor.author | Liang, R | en_HK |
dc.date.accessioned | 2010-05-31T03:44:01Z | - |
dc.date.available | 2010-05-31T03:44:01Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Leukemia And Lymphoma, 2009, v. 50 n. 6, p. 932-936 | en_HK |
dc.identifier.issn | 1042-8194 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59159 | - |
dc.description.abstract | A patient with history of B cell lymphoma treated with rituximab-based chemotherapy relapsed with a blastic CD4+/CD56+ neoplasm that was negative for CD20, CD79a and CD3. The relapse morphology and immunophenotyping were unusual and plasmacytoid dendritic cell (PDC) tumor enters the differential diagnosis. However, expressions of Oct-2 and CD10 in the relapse tumor were both more compatible with B cell than PDC lineage. Molecular investigations showed clonal rearrangements for both immunoglobulin heavy chain (IgH) and T cell receptor (TCR) γ chain gene by polymerase chain reaction (PCR). Furthermore, a clonal relationship with the original B cell lymphoma was demonstrated for all PCR products. Our case illustrated the potential pitfalls and ambiguity of lineage classification based on morphology and immunophenotyping alone, especially for rare and poorly defined entities. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal | en_HK |
dc.relation.ispartof | Leukemia and Lymphoma | en_HK |
dc.rights | Leukemia and Lymphoma. Copyright © Informa Healthcare. | en_HK |
dc.subject | CD4/CD56 | en_HK |
dc.subject | Masquerade | en_HK |
dc.subject | Plasmacytoid dendritic cell tumor | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Antigens, CD20 - analysis | en_HK |
dc.subject.mesh | Antigens, CD4 - analysis | en_HK |
dc.subject.mesh | Antigens, CD56 - analysis | en_HK |
dc.subject.mesh | Base Sequence | en_HK |
dc.subject.mesh | Dendritic Cells - metabolism - pathology | en_HK |
dc.subject.mesh | Diagnosis, Differential | en_HK |
dc.subject.mesh | Flow Cytometry | en_HK |
dc.subject.mesh | Gene Rearrangement | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunoglobulin Heavy Chains - genetics | en_HK |
dc.subject.mesh | Immunophenotyping | en_HK |
dc.subject.mesh | Karyotyping | en_HK |
dc.subject.mesh | Lymphoma, B-Cell - genetics - metabolism - pathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Molecular Sequence Data | en_HK |
dc.subject.mesh | Neoplasm Recurrence, Local | en_HK |
dc.subject.mesh | Neoplastic Stem Cells - metabolism - pathology | en_HK |
dc.subject.mesh | Octamer Transcription Factor-2 - analysis | en_HK |
dc.subject.mesh | Polymerase Chain Reaction | en_HK |
dc.subject.mesh | Receptors, Antigen, T-Cell, gamma-delta - genetics | en_HK |
dc.subject.mesh | Sequence Homology, Nucleic Acid | en_HK |
dc.title | A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=50&issue=6&spage=932&epage=6&date=2009&atitle=A+unique+case+of+B+cell+lymphoma+relapsing+as+CD4/CD56+blastic+neoplasm | en_HK |
dc.identifier.email | So, JC:scc@pathology.hku.hk | en_HK |
dc.identifier.email | Srivastava, G:gopesh@pathology.hku.hk | en_HK |
dc.identifier.email | Liang, R:rliang@hku.hk | en_HK |
dc.identifier.authority | So, JC=rp00391 | en_HK |
dc.identifier.authority | Srivastava, G=rp00365 | en_HK |
dc.identifier.authority | Liang, R=rp00345 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1080/10428190902878463 | en_HK |
dc.identifier.pmid | 19504395 | - |
dc.identifier.scopus | eid_2-s2.0-68449101744 | en_HK |
dc.identifier.hkuros | 159740 | en_HK |
dc.identifier.hkuros | 180718 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-68449101744&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 50 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 932 | en_HK |
dc.identifier.epage | 936 | en_HK |
dc.identifier.isi | WOS:000266810900014 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Au, WY=7202383089 | en_HK |
dc.identifier.scopusauthorid | Wong, KY=7404758500 | en_HK |
dc.identifier.scopusauthorid | Wan, TS=25623981600 | en_HK |
dc.identifier.scopusauthorid | So, JC=7102919978 | en_HK |
dc.identifier.scopusauthorid | Srivastava, G=7202242238 | en_HK |
dc.identifier.scopusauthorid | Liang, R=26643224900 | en_HK |
dc.identifier.issnl | 1026-8022 | - |