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Article: Methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance

TitleMethicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance
Authors
KeywordsmecA
Methicillin-resistant S. aureus
SCCmec
Staphylococcus intermedius
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/meegid
Citation
Infection, Genetics And Evolution, 2009, v. 9 n. 2, p. 283-285 How to Cite?
AbstractBeta-lactam-resistant staphylococci evolved due to widespread nosocomial antibiotic use during the twentieth century, but the last decade has seen the emergence of genotypically distinct resistant bacteria outside hospitals, such as community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). This changing epidemiology suggests that mechanisms other than direct antibiotic selection could be involved in the spread of bacterial resistance. Here we report a 17% prevalence of methicillin-resistant Staphylococcus intermedius (MRSI)-a markedly higher rate than the 0-2% reported in some other series-in a random sample of nasal swabs from healthy pet dogs in Hong Kong. In contrast, MRSA was not detected. Since the mecA mobile genetic element responsible for methicillin resistance has been shown by others to be horizontally transmissible between dogs and humans, our findings suggest that the high prevalence of this resistance vector in companion species is a legitimate concern for public health, and raise the important possibility that pet-acquired methicillin-resistant staphylococci (PA-MRS) could play a role in zoonotic mecA gene spread. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59148
ISSN
2015 Impact Factor: 2.591
2015 SCImago Journal Rankings: 1.431
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEpstein, CRen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorEpstein, RJen_HK
dc.date.accessioned2010-05-31T03:43:49Z-
dc.date.available2010-05-31T03:43:49Z-
dc.date.issued2009en_HK
dc.identifier.citationInfection, Genetics And Evolution, 2009, v. 9 n. 2, p. 283-285en_HK
dc.identifier.issn1567-1348en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59148-
dc.description.abstractBeta-lactam-resistant staphylococci evolved due to widespread nosocomial antibiotic use during the twentieth century, but the last decade has seen the emergence of genotypically distinct resistant bacteria outside hospitals, such as community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). This changing epidemiology suggests that mechanisms other than direct antibiotic selection could be involved in the spread of bacterial resistance. Here we report a 17% prevalence of methicillin-resistant Staphylococcus intermedius (MRSI)-a markedly higher rate than the 0-2% reported in some other series-in a random sample of nasal swabs from healthy pet dogs in Hong Kong. In contrast, MRSA was not detected. Since the mecA mobile genetic element responsible for methicillin resistance has been shown by others to be horizontally transmissible between dogs and humans, our findings suggest that the high prevalence of this resistance vector in companion species is a legitimate concern for public health, and raise the important possibility that pet-acquired methicillin-resistant staphylococci (PA-MRS) could play a role in zoonotic mecA gene spread. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/meegiden_HK
dc.relation.ispartofInfection, Genetics and Evolutionen_HK
dc.subjectmecAen_HK
dc.subjectMethicillin-resistant S. aureusen_HK
dc.subjectSCCmecen_HK
dc.subjectStaphylococcus intermediusen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiologyen_HK
dc.subject.meshDisease Reservoirsen_HK
dc.subject.meshDogs - microbiologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMethicillin-Resistant Staphylococcus aureus - drug effects - isolation & purificationen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshStaphylococcal Infections - epidemiology - microbiologyen_HK
dc.titleMethicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistanceen_HK
dc.typeArticleen_HK
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailEpstein, RJ: repstein@hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityEpstein, RJ=rp00501en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.meegid.2008.11.003en_HK
dc.identifier.pmid19073283-
dc.identifier.scopuseid_2-s2.0-59749104166en_HK
dc.identifier.hkuros162595en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-59749104166&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue2en_HK
dc.identifier.spage283en_HK
dc.identifier.epage285en_HK
dc.identifier.isiWOS:000264049400018-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridEpstein, CR=25936102700en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridEpstein, RJ=34975074500en_HK

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