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Article: Synthesis of Ca-P nanoparticles and fabrication of Ca-P/PHBV nanocomposite microspheres for bone tissue engineering applications

TitleSynthesis of Ca-P nanoparticles and fabrication of Ca-P/PHBV nanocomposite microspheres for bone tissue engineering applications
Authors
KeywordsCalcium phosphate
Microsphere
Nanocomposite
Nanoparticle
Poly(hydroxybutyrate-co-hydroxyvalerate)
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/apsusc
Citation
Applied Surface Science, 2008, v. 255 n. 2, p. 529-533 How to Cite?
AbstractAs the first step in producing totally bioresorbable osteoconductive composite scaffolds for bone tissue engineering using the selective laser sintering technology, bioresorbable nanoparticles of calcium phosphate (Ca-P) similar in composition to β-tricalcium phosphate were synthesized and Ca-P nanoparticle filled poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microspheres were fabricated. The pH of the chemical reaction for Ca-P particle synthesis was found to have significant effects on the morphology and chemical composition of Ca-P precipitated. Ca-P particles produced at the pH of 10.0-11.0 were amorphous, had a Ca:P molar ratio of about 1.5, were spherical in shape and had sizes in the range of 10-30 nm. The Ca-P particles were used to form Ca-P nanocomposite microspheres through a solid-in-oil-in-water (S/O/W) emulsion solvent evaporation process. Ca-P nanoparticles were mostly encapsulated inside the microspheres and some Ca-P nanoparticles were superficially embedded on the microspheres. The Ca-P/PHBV microspheres had an average diameter of about 48 μm which is suitable for selective laser sintering for constructing osteoconductive composite scaffolds. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59088
ISSN
2015 Impact Factor: 3.15
2015 SCImago Journal Rankings: 0.930
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuan, Ben_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorCheung, WLen_HK
dc.date.accessioned2010-05-31T03:42:40Z-
dc.date.available2010-05-31T03:42:40Z-
dc.date.issued2008en_HK
dc.identifier.citationApplied Surface Science, 2008, v. 255 n. 2, p. 529-533en_HK
dc.identifier.issn0169-4332en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59088-
dc.description.abstractAs the first step in producing totally bioresorbable osteoconductive composite scaffolds for bone tissue engineering using the selective laser sintering technology, bioresorbable nanoparticles of calcium phosphate (Ca-P) similar in composition to β-tricalcium phosphate were synthesized and Ca-P nanoparticle filled poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microspheres were fabricated. The pH of the chemical reaction for Ca-P particle synthesis was found to have significant effects on the morphology and chemical composition of Ca-P precipitated. Ca-P particles produced at the pH of 10.0-11.0 were amorphous, had a Ca:P molar ratio of about 1.5, were spherical in shape and had sizes in the range of 10-30 nm. The Ca-P particles were used to form Ca-P nanocomposite microspheres through a solid-in-oil-in-water (S/O/W) emulsion solvent evaporation process. Ca-P nanoparticles were mostly encapsulated inside the microspheres and some Ca-P nanoparticles were superficially embedded on the microspheres. The Ca-P/PHBV microspheres had an average diameter of about 48 μm which is suitable for selective laser sintering for constructing osteoconductive composite scaffolds. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/apsuscen_HK
dc.relation.ispartofApplied Surface Scienceen_HK
dc.rightsApplied Surface Science. Copyright © Elsevier BV.en_HK
dc.subjectCalcium phosphateen_HK
dc.subjectMicrosphereen_HK
dc.subjectNanocompositeen_HK
dc.subjectNanoparticleen_HK
dc.subjectPoly(hydroxybutyrate-co-hydroxyvalerate)en_HK
dc.titleSynthesis of Ca-P nanoparticles and fabrication of Ca-P/PHBV nanocomposite microspheres for bone tissue engineering applicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0169-4332&volume=255&spage=529&epage=533 &date=2008&atitle=Synthesis+of+Ca-P+Nanoparticles+and+Fabrication+of+Ca-P/PHBV+Nanocomposite+Microspheres+for+Bone+Tissue+Engineering+Applicationsen_HK
dc.identifier.emailWang, M: memwang@hku.hken_HK
dc.identifier.emailCheung, WL: wlcheung@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.apsusc.2008.06.057en_HK
dc.identifier.scopuseid_2-s2.0-54349122765en_HK
dc.identifier.hkuros157733en_HK
dc.identifier.hkuros157805-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54349122765&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume255en_HK
dc.identifier.issue2en_HK
dc.identifier.spage529en_HK
dc.identifier.epage533en_HK
dc.identifier.isiWOS:000260510600076-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridDuan, B=7005042335en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridZhou, WY=26636766600en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK

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