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Article: Mechanics model for actin-based motility

TitleMechanics model for actin-based motility
Authors
Issue Date2009
PublisherAmerican Physical Society. The Journal's web site is located at http://pre.aps.org
Citation
Physical Review E - Statistical, Nonlinear, And Soft Matter Physics, 2009, v. 79 n. 2, article no. 021916 How to Cite?
AbstractWe present here a mechanics model for the force generation by actin polymerization. The possible adhesions between the actin filaments and the load surface, as well as the nucleation and capping of filament tips, are included in this model on top of the well-known elastic Brownian ratchet formulation. A closed form solution is provided from which the force-velocity relationship, summarizing the mechanics of polymerization, can be drawn. Model predictions on the velocity of moving beads driven by actin polymerization are consistent with experiment observations. This model also seems capable of explaining the enhanced actin-based motility of Listeria monocytogenes and beads by the presence of Vasodilator-stimulated phosphoprotein, as observed in recent experiments. © 2009 The American Physical Society.
Persistent Identifierhttp://hdl.handle.net/10722/59049
ISSN
2014 Impact Factor: 2.288
2015 SCImago Journal Rankings: 0.999
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Yen_HK
dc.date.accessioned2010-05-31T03:42:01Z-
dc.date.available2010-05-31T03:42:01Z-
dc.date.issued2009en_HK
dc.identifier.citationPhysical Review E - Statistical, Nonlinear, And Soft Matter Physics, 2009, v. 79 n. 2, article no. 021916en_HK
dc.identifier.issn1539-3755en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59049-
dc.description.abstractWe present here a mechanics model for the force generation by actin polymerization. The possible adhesions between the actin filaments and the load surface, as well as the nucleation and capping of filament tips, are included in this model on top of the well-known elastic Brownian ratchet formulation. A closed form solution is provided from which the force-velocity relationship, summarizing the mechanics of polymerization, can be drawn. Model predictions on the velocity of moving beads driven by actin polymerization are consistent with experiment observations. This model also seems capable of explaining the enhanced actin-based motility of Listeria monocytogenes and beads by the presence of Vasodilator-stimulated phosphoprotein, as observed in recent experiments. © 2009 The American Physical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Physical Society. The Journal's web site is located at http://pre.aps.orgen_HK
dc.relation.ispartofPhysical Review E - Statistical, Nonlinear, and Soft Matter Physicsen_HK
dc.rightsPhysical Review E (Statistical, Nonlinear, and Soft Matter Physics). Copyright © American Physical Society.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMechanics model for actin-based motilityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1539-3755&volume=79&spage=021916&epage=&date=2009&atitle=Mechanics+model+for+actin-based+motilityen_HK
dc.identifier.emailLin, Y:ylin@hku.hken_HK
dc.identifier.authorityLin, Y=rp00080en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1103/PhysRevE.79.021916en_HK
dc.identifier.scopuseid_2-s2.0-63149180566en_HK
dc.identifier.hkuros160697en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63149180566&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue2en_HK
dc.identifier.spagearticle no. 021916-
dc.identifier.epagearticle no. 021916-
dc.identifier.eissn1550-2376-
dc.identifier.isiWOS:000263807300095-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLin, Y=7406585339en_HK

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