File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Optimum size of a molecular bond cluster in adhesion

TitleOptimum size of a molecular bond cluster in adhesion
Authors
Issue Date2008
PublisherAmerican Physical Society. The Journal's web site is located at http://pre.aps.org
Citation
Physical Review E - Statistical, Nonlinear, And Soft Matter Physics, 2008, v. 78 n. 2, article no. 021909 How to Cite?
AbstractThe strength of a bonded interface is considered for the case in which bonding is the result of clusters of discrete bonds distributed along the interface. Assumptions appropriate for the case of adhesion of biological cells to an extracellular matrix are introduced as a basis for the discussion. It is observed that those individual bonds nearest to the edges of a cluster are necessarily subjected to disproportionately large forces in transmitting loads across the interface, in analogy with well-known behavior in elastic crack mechanics. Adopting Bell's model for the kinetics of bond response under force, a stochastic model leading to a dependence of interface strength on cluster size is developed and analyzed. On the basis of this model, it is demonstrated that there is an optimum cluster size for maximum strength. This size arises from the competition between the nonuniform force distribution among bonds, which tends to promote smaller clusters, and stochastic response allowing bond reformation, which tends to promote larger clusters. The model results have been confirmed by means of direct Monte Carlo simulations. This analysis may be relevant to the observation that mature focal adhesion zones in cell bonding are found to have a relatively uniform size. © 2008 The American Physical Society.
Persistent Identifierhttp://hdl.handle.net/10722/59032
ISSN
2014 Impact Factor: 2.288
2015 SCImago Journal Rankings: 0.999
ISI Accession Number ID
Funding AgencyGrant Number
MRSEC
National Science Foundation at Brown UniversityDMR-0520651
Funding Information:

We are grateful to Professor H. Gao and J. Qian at Brown University for stimulating discussions. This work was supported primarily by the MRSEC Program, funded by the National Science Foundation at Brown University under Grant No. DMR-0520651.

References

 

DC FieldValueLanguage
dc.contributor.authorLin, Yen_HK
dc.contributor.authorFreund, LBen_HK
dc.date.accessioned2010-05-31T03:41:44Z-
dc.date.available2010-05-31T03:41:44Z-
dc.date.issued2008en_HK
dc.identifier.citationPhysical Review E - Statistical, Nonlinear, And Soft Matter Physics, 2008, v. 78 n. 2, article no. 021909en_HK
dc.identifier.issn1539-3755en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59032-
dc.description.abstractThe strength of a bonded interface is considered for the case in which bonding is the result of clusters of discrete bonds distributed along the interface. Assumptions appropriate for the case of adhesion of biological cells to an extracellular matrix are introduced as a basis for the discussion. It is observed that those individual bonds nearest to the edges of a cluster are necessarily subjected to disproportionately large forces in transmitting loads across the interface, in analogy with well-known behavior in elastic crack mechanics. Adopting Bell's model for the kinetics of bond response under force, a stochastic model leading to a dependence of interface strength on cluster size is developed and analyzed. On the basis of this model, it is demonstrated that there is an optimum cluster size for maximum strength. This size arises from the competition between the nonuniform force distribution among bonds, which tends to promote smaller clusters, and stochastic response allowing bond reformation, which tends to promote larger clusters. The model results have been confirmed by means of direct Monte Carlo simulations. This analysis may be relevant to the observation that mature focal adhesion zones in cell bonding are found to have a relatively uniform size. © 2008 The American Physical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Physical Society. The Journal's web site is located at http://pre.aps.orgen_HK
dc.relation.ispartofPhysical Review E - Statistical, Nonlinear, and Soft Matter Physicsen_HK
dc.rightsPhysical Review E (Statistical, Nonlinear, and Soft Matter Physics). Copyright © American Physical Society.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleOptimum size of a molecular bond cluster in adhesionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1539-3755&volume=78&spage=021909&epage=&date=2008&atitle=Optimum+size+of+a+molecular+bond+cluster+in+adhesionen_HK
dc.identifier.emailLin, Y:ylin@hku.hken_HK
dc.identifier.authorityLin, Y=rp00080en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1103/PhysRevE.78.021909en_HK
dc.identifier.scopuseid_2-s2.0-50149091274en_HK
dc.identifier.hkuros160696en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50149091274&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue2en_HK
dc.identifier.spagearticle no. 021909-
dc.identifier.epagearticle no. 021909-
dc.identifier.eissn1550-2376-
dc.identifier.isiWOS:000259263600097-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLin, Y=7406585339en_HK
dc.identifier.scopusauthoridFreund, LB=7102315296en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats