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Article: Attitudes of Chinese couples in Hong Kong regarding using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a 'Saviour Child'

TitleAttitudes of Chinese couples in Hong Kong regarding using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a 'Saviour Child'
Authors
Keywords'Savior Child'
Chinese traditions
Ethics
Preimplantation genetic diagnosis
Preimplantation HLA-typing
Issue Date2009
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2009, v. 29 n. 6, p. 593-605 How to Cite?
AbstractObjectives: To investigate Hong Kong couples' attitudes and concerns about using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a disease-free and tissue-compatible 'Saviour Child (SC)' to save an afflicted sibling. Methods: Two cohorts of Chinese couples, one with natural pregnancies and the other receiving in vitro fertilization (IVF) services, were studied using a structured questionnaire. Results: Although most couples believed that embryos possess moral rights, they considered it acceptable to reproduce a donor child if it was safe for the child, and tissue transplantation was the only available treatment for the sick sibling. Most couples believed that the donor child would not suffer adverse physical or psychological effects but rather would gain positive psychological benefits, and opined that parents using PGD/HLA-typing suffer sacrificially for their children. In response to one specific question, one-third of the couples agreed to use the donor child as a lifetime organ donor and supported the use of PGD for non-medical gender selection. One-quarter were willing to reject PGD/HLA-typing because of its potential for non-medical genetic enhancement. Conclusion: Probably influenced by the Chinese tradition of strong familism, couples in Hong Kong generally show positive attitudes towards using PGD/HLA-typing to reproduce a 'SC' to save a sibling affected with life-threatening diseases amenable to treatment with genetically compatible tissue. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/58882
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
Funding AgencyGrant Number
University Strategic Research Theme
University of Hong Kong10206152.11222.21700.302.01
Funding Information:

This study was supported in part by a grant to the University Strategic Research Theme: Genomics, Proteomics, Bioinfortnatics & ELSI, The University of Hong Kong, grant No.10206152.11222.21700.302.01. The authors declare no conflict of interest of any kind.

References

 

DC FieldValueLanguage
dc.contributor.authorHui, ECen_HK
dc.contributor.authorChan, Cen_HK
dc.contributor.authorLiu, Aen_HK
dc.contributor.authorChow, Ken_HK
dc.date.accessioned2010-05-31T03:38:56Z-
dc.date.available2010-05-31T03:38:56Z-
dc.date.issued2009en_HK
dc.identifier.citationPrenatal Diagnosis, 2009, v. 29 n. 6, p. 593-605en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58882-
dc.description.abstractObjectives: To investigate Hong Kong couples' attitudes and concerns about using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a disease-free and tissue-compatible 'Saviour Child (SC)' to save an afflicted sibling. Methods: Two cohorts of Chinese couples, one with natural pregnancies and the other receiving in vitro fertilization (IVF) services, were studied using a structured questionnaire. Results: Although most couples believed that embryos possess moral rights, they considered it acceptable to reproduce a donor child if it was safe for the child, and tissue transplantation was the only available treatment for the sick sibling. Most couples believed that the donor child would not suffer adverse physical or psychological effects but rather would gain positive psychological benefits, and opined that parents using PGD/HLA-typing suffer sacrificially for their children. In response to one specific question, one-third of the couples agreed to use the donor child as a lifetime organ donor and supported the use of PGD for non-medical gender selection. One-quarter were willing to reject PGD/HLA-typing because of its potential for non-medical genetic enhancement. Conclusion: Probably influenced by the Chinese tradition of strong familism, couples in Hong Kong generally show positive attitudes towards using PGD/HLA-typing to reproduce a 'SC' to save a sibling affected with life-threatening diseases amenable to treatment with genetically compatible tissue. Copyright © 2009 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subject'Savior Child'en_HK
dc.subjectChinese traditionsen_HK
dc.subjectEthicsen_HK
dc.subjectPreimplantation genetic diagnosisen_HK
dc.subjectPreimplantation HLA-typingen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAttitude to Healthen_HK
dc.subject.meshCord Blood Stem Cell Transplantation - ethicsen_HK
dc.subject.meshData Collectionen_HK
dc.subject.meshDirected Tissue Donation - ethicsen_HK
dc.subject.meshEmbryo Research - ethicsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFertilization in Vitroen_HK
dc.subject.meshHistocompatibility Testingen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshParentsen_HK
dc.subject.meshPreimplantation Diagnosis - ethicsen_HK
dc.subject.meshSex Preselection - ethicsen_HK
dc.subject.meshSibling Relationsen_HK
dc.titleAttitudes of Chinese couples in Hong Kong regarding using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a 'Saviour Child'en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=29&spage=p 593&epage=605&date=2009&atitle=Attitudes+of+Chinese+couples+in+Hong+Kong+regarding+using+preimplantation+genetic+diagnosis+(PGD)+and+human+leukocyte+antigens+(HLA)+typing+to+conceive+a+%27Saviour+Child%27en_HK
dc.identifier.emailHui, EC: edwinhui@hkucc.hku.hken_HK
dc.identifier.emailLiu, A: athena@hku.hken_HK
dc.identifier.authorityHui, EC=rp00472en_HK
dc.identifier.authorityLiu, A=rp01264en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pd.2255en_HK
dc.identifier.pmid19294755-
dc.identifier.scopuseid_2-s2.0-67049115790en_HK
dc.identifier.hkuros166531en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67049115790&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue6en_HK
dc.identifier.spage593en_HK
dc.identifier.epage605en_HK
dc.identifier.eissn1097-0223-
dc.identifier.isiWOS:000266960800007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHui, EC=35319968700en_HK
dc.identifier.scopusauthoridChan, C=26643394500en_HK
dc.identifier.scopusauthoridLiu, A=9746606700en_HK
dc.identifier.scopusauthoridChow, K=26646389100en_HK

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