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Article: Magnetization transfer (MT) asymmetry around the water resonance in human cervical spinal cord

TitleMagnetization transfer (MT) asymmetry around the water resonance in human cervical spinal cord
Authors
KeywordsAPT
Asymmetry
CEST
Magnetization transfer
Spinal cord
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 29 n. 3, p. 523-528 How to Cite?
AbstractPurpose: To demonstrate the presence of magnetization transfer (MT) asymmetry in human cervical spinal cord due to the interaction between bulk water and semisolid mac- romolecules (conventional MT), and the chemical exchange dependent saturation transfer (CEST) effect. Materials and Methods: MT asymmetry in the cervical spinal cord (C3/C4-C5) was investigated in 14 healthy male subjects with a 3T magnetic resonance (MR) system. Both spin-echo (SE) and gradient-echo (GE) echo-planar imaging (EPI) sequences, with low-power off-resonance radiofre-quency irradiation at different frequency offsets, were used. Results: Our results show that the z-spectrum in gray/white matter (GM/WM) is asymmetrical about the water resonance frequency in both SE-EPI and GE-EPI, with a more significant saturation effect at the lower frequencies (negative frequency offset) far away from water and at the higher frequencies (positive offset) close to water. These are attributed mainly to the conventional MT and CEST effects respectively. Furthermore, the amplitude of MT asymmetry is larger in the SE-EPI sequence than in the GE-EPI sequence in the frequency range of amide protons. Conclusion: Our results demonstrate the presence of MT asymmetry in human cervical spinal cord, which is consistent with the ones reported in the brain. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58812
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, MCen_HK
dc.contributor.authorHua, Jen_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorLuk, KDen_HK
dc.contributor.authorLam, EYen_HK
dc.date.accessioned2010-05-31T03:37:20Z-
dc.date.available2010-05-31T03:37:20Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 29 n. 3, p. 523-528en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58812-
dc.description.abstractPurpose: To demonstrate the presence of magnetization transfer (MT) asymmetry in human cervical spinal cord due to the interaction between bulk water and semisolid mac- romolecules (conventional MT), and the chemical exchange dependent saturation transfer (CEST) effect. Materials and Methods: MT asymmetry in the cervical spinal cord (C3/C4-C5) was investigated in 14 healthy male subjects with a 3T magnetic resonance (MR) system. Both spin-echo (SE) and gradient-echo (GE) echo-planar imaging (EPI) sequences, with low-power off-resonance radiofre-quency irradiation at different frequency offsets, were used. Results: Our results show that the z-spectrum in gray/white matter (GM/WM) is asymmetrical about the water resonance frequency in both SE-EPI and GE-EPI, with a more significant saturation effect at the lower frequencies (negative frequency offset) far away from water and at the higher frequencies (positive offset) close to water. These are attributed mainly to the conventional MT and CEST effects respectively. Furthermore, the amplitude of MT asymmetry is larger in the SE-EPI sequence than in the GE-EPI sequence in the frequency range of amide protons. Conclusion: Our results demonstrate the presence of MT asymmetry in human cervical spinal cord, which is consistent with the ones reported in the brain. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAPTen_HK
dc.subjectAsymmetryen_HK
dc.subjectCESTen_HK
dc.subjectMagnetization transferen_HK
dc.subjectSpinal corden_HK
dc.subject.meshAdulten_HK
dc.subject.meshCervical Vertebrae - anatomy & histologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisted - methodsen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshSpinal Cord - anatomy & histologyen_HK
dc.subject.meshWateren_HK
dc.subject.meshYoung Adulten_HK
dc.titleMagnetization transfer (MT) asymmetry around the water resonance in human cervical spinal corden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=29&spage=&epage=&date=2009&atitle=Magnetization+Transfer+(MT)+asymmetry+around+the+water+resonance+in+human+cervical+spinal+corden_HK
dc.identifier.emailHu, Y:yhud@hku.hken_HK
dc.identifier.emailLuk, KD:hcm21000@hku.hken_HK
dc.identifier.emailLam, EY:elam@eee.hku.hken_HK
dc.identifier.authorityHu, Y=rp00432en_HK
dc.identifier.authorityLuk, KD=rp00333en_HK
dc.identifier.authorityLam, EY=rp00131en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21610en_HK
dc.identifier.pmid19243033-
dc.identifier.scopuseid_2-s2.0-63449113337en_HK
dc.identifier.hkuros158726en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63449113337&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue3en_HK
dc.identifier.spage523en_HK
dc.identifier.epage528en_HK
dc.identifier.isiWOS:000263923000003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, MC=7202076279en_HK
dc.identifier.scopusauthoridHua, J=36725108400en_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK
dc.identifier.scopusauthoridLuk, KD=7201921573en_HK
dc.identifier.scopusauthoridLam, EY=7102890004en_HK

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