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Article: A computational study on the biomechanical factors related to stent-graft models in the thoracic aorta

TitleA computational study on the biomechanical factors related to stent-graft models in the thoracic aorta
Authors
KeywordsDrag force and computational fluid dynamics
Endovascular stent-graft
Modeling of blood flow
Thoracic aorta
Issue Date2008
PublisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-40109-70-67951916-0,00.html?changeHeader=true
Citation
Medical And Biological Engineering And Computing, 2008, v. 46 n. 11, p. 1129-1138 How to Cite?
AbstractEndovascular aortic stent-graft is a new, minimally invasive procedure for treating thoracic aortic diseases, and has quickly evolved to be one of the standard treatments subject to anatomic constraints. This procedure involves the placement of a self-expanding stent-graft system in a high-flow thoracic aorta. Stent-graft deployment in the thoracic aorta, especially close to the aortic arch, normally experiences a significant drag force which might lead to the risk of stent-graft failure. A comprehensive investigation on the biomechanical factors affecting the drag force on a stent-graft in the thoracic aorta is thus in order, and the goal is to perform an in-depth study on the contributing biomechanical factors. Three factors affecting the deployed stent-graft are considered, namely, the internal diameter of the vessel, the starting position of the graft and the diameter of curvature of the aortic arch. Computational fluid dynamic techniques are applied to model the blood flow. The inlet velocity and outlet pressure are assumed to be pulsatile. The three-dimensional continuity equation and the time-dependent Navier-Stokes equations for an incompressible fluid were solved numerically. The drag force due to the change of momentum within the stent-graft and the shear stress were calculated and analyzed. The drag force on a stent-graft will depend critically on the internal diameter and the starting position of stent-graft deployment. Larger internal diameter leads to larger drag force and the stent-graft deployed at the more distal position may be associated with significantly diminished drag force. Smaller diameter of curvature of the aortic arch probably results in a decline of the drag force on the stent-graft, even though this factor merely causes only a modest difference. These findings may have important implications for the choice and design of stent-grafts in the future. © International Federation for Medical and Biological Engineering 2008.
Persistent Identifierhttp://hdl.handle.net/10722/58808
ISSN
2015 Impact Factor: 1.797
2015 SCImago Journal Rankings: 0.798
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_HK
dc.contributor.authorFung, GSKen_HK
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorChow, KWen_HK
dc.date.accessioned2010-05-31T03:37:16Z-
dc.date.available2010-05-31T03:37:16Z-
dc.date.issued2008en_HK
dc.identifier.citationMedical And Biological Engineering And Computing, 2008, v. 46 n. 11, p. 1129-1138en_HK
dc.identifier.issn0140-0118en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58808-
dc.description.abstractEndovascular aortic stent-graft is a new, minimally invasive procedure for treating thoracic aortic diseases, and has quickly evolved to be one of the standard treatments subject to anatomic constraints. This procedure involves the placement of a self-expanding stent-graft system in a high-flow thoracic aorta. Stent-graft deployment in the thoracic aorta, especially close to the aortic arch, normally experiences a significant drag force which might lead to the risk of stent-graft failure. A comprehensive investigation on the biomechanical factors affecting the drag force on a stent-graft in the thoracic aorta is thus in order, and the goal is to perform an in-depth study on the contributing biomechanical factors. Three factors affecting the deployed stent-graft are considered, namely, the internal diameter of the vessel, the starting position of the graft and the diameter of curvature of the aortic arch. Computational fluid dynamic techniques are applied to model the blood flow. The inlet velocity and outlet pressure are assumed to be pulsatile. The three-dimensional continuity equation and the time-dependent Navier-Stokes equations for an incompressible fluid were solved numerically. The drag force due to the change of momentum within the stent-graft and the shear stress were calculated and analyzed. The drag force on a stent-graft will depend critically on the internal diameter and the starting position of stent-graft deployment. Larger internal diameter leads to larger drag force and the stent-graft deployed at the more distal position may be associated with significantly diminished drag force. Smaller diameter of curvature of the aortic arch probably results in a decline of the drag force on the stent-graft, even though this factor merely causes only a modest difference. These findings may have important implications for the choice and design of stent-grafts in the future. © International Federation for Medical and Biological Engineering 2008.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-40109-70-67951916-0,00.html?changeHeader=trueen_HK
dc.relation.ispartofMedical and Biological Engineering and Computingen_HK
dc.subjectDrag force and computational fluid dynamicsen_HK
dc.subjectEndovascular stent-graften_HK
dc.subjectModeling of blood flowen_HK
dc.subjectThoracic aortaen_HK
dc.subject.meshAorta, Thoracic - physiopathology - surgeryen_HK
dc.subject.meshAortic Diseases - physiopathology - surgeryen_HK
dc.subject.meshBlood Vessel Prosthesisen_HK
dc.subject.meshHemorheologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshModels, Cardiovascularen_HK
dc.subject.meshProsthesis Designen_HK
dc.subject.meshPulsatile Flowen_HK
dc.subject.meshStentsen_HK
dc.titleA computational study on the biomechanical factors related to stent-graft models in the thoracic aortaen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.emailChow, KW: kwchow@hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.identifier.authorityChow, KW=rp00112en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11517-008-0361-8en_HK
dc.identifier.pmid18618162en_HK
dc.identifier.scopuseid_2-s2.0-56549099107en_HK
dc.identifier.hkuros154610en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56549099107&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1129en_HK
dc.identifier.epage1138en_HK
dc.identifier.isiWOS:000260960200008-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridFung, GSK=7004213392en_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridChow, KW=13605209900en_HK

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