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Article: Microbubbles as a novel contrast agent for brain MRI

TitleMicrobubbles as a novel contrast agent for brain MRI
Authors
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2009, v. 46 n. 3, p. 658-664 How to Cite?
AbstractGas-filled microbubbles have the potential to become a unique MR contrast agent due to their magnetic susceptibility effect, biocompatibility and localized manipulation via ultrasound cavitation. In this study, two types of microbubbles, custom-made albumin-coated microbubbles (A-MB) and a commercially available lipid-based clinical ultrasound contrast agent (SonoVue®), were investigated with in vivo dynamic brain MRI in Sprague-Dawley rats at 7 T. Microbubble suspensions (A-MB: 0.2 mL of ∼ 4% volume fraction; SonoVue®: 0.2 mL of ∼ 3.5% volume fraction) were injected intravenously. Transverse relaxation rate enhancements (ΔR2 *) of 2.49 ± 1.00 s- 1 for A-MB and 2.41 ± 1.18 s- 1 for SonoVue® were observed in the brain (N = 5). Brain ΔR2 * maps were computed, yielding results similar to the cerebral blood volume maps obtained with a common MR blood pool contrast agent. Microbubble suspension ΔR2 * was measured for different volume fractions. These results indicate that gas-filled microbubbles can serve as an intravascular contrast agent for brain MRI at high field. Such capability has the potential to lead to real-time MRI guidance in various microbubble-based drug delivery and therapeutic applications in the central nervous system. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58788
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCERG HKU 7642/06M
Funding Information:

We thank Dr. Joseph C.K. Leung of the Department of Medicine and Dr. Ke Xia Cai at the Laboratory of Biomedical Imaging and Signal Processing of the University of Hong Kong for assistance. This work was supported by the Hong Kong Research Grant Council (CERG HKU 7642/06M).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorChow, AMen_HK
dc.contributor.authorGuo, Hen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:36:55Z-
dc.date.available2010-05-31T03:36:55Z-
dc.date.issued2009en_HK
dc.identifier.citationNeuroimage, 2009, v. 46 n. 3, p. 658-664en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58788-
dc.description.abstractGas-filled microbubbles have the potential to become a unique MR contrast agent due to their magnetic susceptibility effect, biocompatibility and localized manipulation via ultrasound cavitation. In this study, two types of microbubbles, custom-made albumin-coated microbubbles (A-MB) and a commercially available lipid-based clinical ultrasound contrast agent (SonoVue®), were investigated with in vivo dynamic brain MRI in Sprague-Dawley rats at 7 T. Microbubble suspensions (A-MB: 0.2 mL of ∼ 4% volume fraction; SonoVue®: 0.2 mL of ∼ 3.5% volume fraction) were injected intravenously. Transverse relaxation rate enhancements (ΔR2 *) of 2.49 ± 1.00 s- 1 for A-MB and 2.41 ± 1.18 s- 1 for SonoVue® were observed in the brain (N = 5). Brain ΔR2 * maps were computed, yielding results similar to the cerebral blood volume maps obtained with a common MR blood pool contrast agent. Microbubble suspension ΔR2 * was measured for different volume fractions. These results indicate that gas-filled microbubbles can serve as an intravascular contrast agent for brain MRI at high field. Such capability has the potential to lead to real-time MRI guidance in various microbubble-based drug delivery and therapeutic applications in the central nervous system. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - anatomy & histologyen_HK
dc.subject.meshContrast Mediaen_HK
dc.subject.meshImage Enhancement - methodsen_HK
dc.subject.meshMicrobubblesen_HK
dc.subject.meshPhospholipids - diagnostic useen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSulfur Hexafluoride - diagnostic useen_HK
dc.titleMicrobubbles as a novel contrast agent for brain MRIen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=46&spage=658&epage=664&date=2009&atitle=Microbubbles+as+a+novel+contrast+agent+for+brain+MRIen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2009.02.037en_HK
dc.identifier.pmid19269337-
dc.identifier.scopuseid_2-s2.0-64949161417en_HK
dc.identifier.hkuros161944en_HK
dc.identifier.hkuros177019-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64949161417&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue3en_HK
dc.identifier.spage658en_HK
dc.identifier.epage664en_HK
dc.identifier.isiWOS:000265938700013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridGuo, H=12774450700en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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