File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: MR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models

TitleMR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models
Authors
KeywordsDTI
In farct size
Infarct location
Myocardial fiber
Myocardium infarction
Remodeling
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 29 n. 2, p. 305-312 How to Cite?
AbstractPurpose: To investigate the effect of infarct size and location on left ventricular (LV) functional and microstructural alterations in well-established porcine models. Materials and Methods: Myocardium infarction was induced in mini-pigs at apical septum (Group 1, n = 6) or basal lateral wall (Group 2, n = 6) by permanent occlusion of the left anterior descending or left circumflex coronary artery, respectively. In vivo cardiac magnetic resonance (CMR) was performed 4 and 13 weeks later. Hearts were then excised and examined by ex vivo diffusion tensor imaging (DTI) for myocardium structural changes in infarct, adjacent and remote regions. Results: LV ejection fractions correlated negatively with infarct sizes. Between week 4 and 13, Group 1 exhibited more changes in end-systolic volume, LV mass, and ejection fraction, although it showed a smaller infarct volume percentage. Ex vivo results revealed the decreased water diffusion fractional anisotropy and increased diffusivities in infarct region in correlation with infarct size, but with no significant difference between the two groups. However, LV myocardial double-helical fiber architecture was found to alter in Group 1, shifting more towards left-handed direction as compared to controls. Conclusion: Postinfarct LV functional and structural remodeling is affected by both infarct size and location. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58785
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant Council
University of Hong Kong CRCG grants
Funding Information:

Contract grant sponsor: Hong Kong Research Grant Council; Contract grant sponsor: University of Hong Kong CRCG grants.

References

 

DC FieldValueLanguage
dc.contributor.authorWu, Yen_HK
dc.contributor.authorChan, CWen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorLiao, Sen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:36:52Z-
dc.date.available2010-05-31T03:36:52Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 29 n. 2, p. 305-312en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58785-
dc.description.abstractPurpose: To investigate the effect of infarct size and location on left ventricular (LV) functional and microstructural alterations in well-established porcine models. Materials and Methods: Myocardium infarction was induced in mini-pigs at apical septum (Group 1, n = 6) or basal lateral wall (Group 2, n = 6) by permanent occlusion of the left anterior descending or left circumflex coronary artery, respectively. In vivo cardiac magnetic resonance (CMR) was performed 4 and 13 weeks later. Hearts were then excised and examined by ex vivo diffusion tensor imaging (DTI) for myocardium structural changes in infarct, adjacent and remote regions. Results: LV ejection fractions correlated negatively with infarct sizes. Between week 4 and 13, Group 1 exhibited more changes in end-systolic volume, LV mass, and ejection fraction, although it showed a smaller infarct volume percentage. Ex vivo results revealed the decreased water diffusion fractional anisotropy and increased diffusivities in infarct region in correlation with infarct size, but with no significant difference between the two groups. However, LV myocardial double-helical fiber architecture was found to alter in Group 1, shifting more towards left-handed direction as compared to controls. Conclusion: Postinfarct LV functional and structural remodeling is affected by both infarct size and location. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectDTIen_HK
dc.subjectIn farct sizeen_HK
dc.subjectInfarct locationen_HK
dc.subjectMyocardial fiberen_HK
dc.subjectMyocardium infarctionen_HK
dc.subjectRemodelingen_HK
dc.subject.meshAnimals-
dc.subject.meshDiffusion Magnetic Resonance Imaging - methods-
dc.subject.meshMyocardial Infarction - pathology-
dc.subject.meshVentricular Dysfunction, Left - pathology-
dc.subject.meshVentricular Remodeling - physiology-
dc.titleMR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine modelsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=29&issue=2&spage=305&epage=312&date=2009&atitle=MR+study+of+the+effect+of+infarct+size+and+location+on+left+ventricular+remodeling+in+porcine+modelsen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21598en_HK
dc.identifier.pmid19161181-
dc.identifier.scopuseid_2-s2.0-60549113348en_HK
dc.identifier.hkuros161920en_HK
dc.identifier.hkuros162143-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60549113348&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage305en_HK
dc.identifier.epage312en_HK
dc.identifier.isiWOS:000262819300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, Y=8940205500en_HK
dc.identifier.scopusauthoridChan, CW=7404813871en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridLiao, S=22433820700en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats