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Article: GD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma

TitleGD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma
Authors
Keywordsaqueous-vitreous interface
chronic glaucoma
Gd-DTPA enhanced magnetic resonance imaging
intraocular pressure
ocular transport
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexer
Citation
Experimental Eye Research, 2008, v. 87 n. 4, p. 334-341 How to Cite?
AbstractGlaucoma is a neurodegenerative disease of the visual system characterized by the elevation of intraocular pressure. While this elevated pressure is related to an increased resistance to the outflow of aqueous humor from the eye, their impacts to the etiology and pathogenesis of the disease are not fully understood. This study aims to employ in vivo Gd-DTPA enhanced magnetic resonance imaging to evaluate the ocular transport following an induction of ocular hypertension in a rat model of chronic glaucoma. An experimental ocular hypertension model was induced in adult rats using an argon laser to photocoagulate the episcleral and limbal veins on the surface of the eyeball. The enhancements of the MRI signal intensity in the anterior chamber and vitreous body were measured as a function of time following systemic administration of Gd-DTPA solution at 3 mmol/kg. Results showed a progressive T1-weighted signal increase in the vitreous body of the glaucomatous eye but not the control eye. This increase occurred earlier in the anterior vitreous body than the preretinal vitreous. Further, there was an earlier Gd-DTPA transport into the anterior chamber in the majority of glaucomatous eyes. Our findings revealed the leakage of Gd-DTPA at the aqueous-vitreous interface, which was likely resulted from increased permeability of blood-aqueous or aqueous-vitreous barrier. These may explain the sources of changing biochemical compositions in the glaucomatous chamber components, which may implicate the cascades of neurodegenerative processes in the retina and the optic nerve. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58768
ISSN
2015 Impact Factor: 2.998
2015 SCImago Journal Rankings: 1.218
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant Council
University of Hong Kong CRCG
Funding Information:

This work was supported in part by Hong Kong Research Grant Council and The University of Hong Kong CRCG grant.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorFu, Qlen_HK
dc.contributor.authorGuo, Hen_HK
dc.contributor.authorSo, Kfen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:36:34Z-
dc.date.available2010-05-31T03:36:34Z-
dc.date.issued2008en_HK
dc.identifier.citationExperimental Eye Research, 2008, v. 87 n. 4, p. 334-341en_HK
dc.identifier.issn0014-4835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58768-
dc.description.abstractGlaucoma is a neurodegenerative disease of the visual system characterized by the elevation of intraocular pressure. While this elevated pressure is related to an increased resistance to the outflow of aqueous humor from the eye, their impacts to the etiology and pathogenesis of the disease are not fully understood. This study aims to employ in vivo Gd-DTPA enhanced magnetic resonance imaging to evaluate the ocular transport following an induction of ocular hypertension in a rat model of chronic glaucoma. An experimental ocular hypertension model was induced in adult rats using an argon laser to photocoagulate the episcleral and limbal veins on the surface of the eyeball. The enhancements of the MRI signal intensity in the anterior chamber and vitreous body were measured as a function of time following systemic administration of Gd-DTPA solution at 3 mmol/kg. Results showed a progressive T1-weighted signal increase in the vitreous body of the glaucomatous eye but not the control eye. This increase occurred earlier in the anterior vitreous body than the preretinal vitreous. Further, there was an earlier Gd-DTPA transport into the anterior chamber in the majority of glaucomatous eyes. Our findings revealed the leakage of Gd-DTPA at the aqueous-vitreous interface, which was likely resulted from increased permeability of blood-aqueous or aqueous-vitreous barrier. These may explain the sources of changing biochemical compositions in the glaucomatous chamber components, which may implicate the cascades of neurodegenerative processes in the retina and the optic nerve. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexeren_HK
dc.relation.ispartofExperimental Eye Researchen_HK
dc.subjectaqueous-vitreous interfaceen_HK
dc.subjectchronic glaucomaen_HK
dc.subjectGd-DTPA enhanced magnetic resonance imagingen_HK
dc.subjectintraocular pressureen_HK
dc.subjectocular transporten_HK
dc.subject.meshAnimals-
dc.subject.meshAnterior Chamber - metabolism-
dc.subject.meshAqueous Humor - physiology-
dc.subject.meshBiological Transport-
dc.subject.meshGlaucoma - etiology - metabolism - physiopathology-
dc.titleGD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-4835&volume=87&issue=4&spage=334&epage=341&date=2008&atitle=Gd-DTPA+enhanced+MRI+of+ocular+transport+in+a+rat+model+of+chronic+glaucomaen_HK
dc.identifier.emailSo, Kf:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authoritySo, Kf=rp00329en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.exer.2008.06.015en_HK
dc.identifier.pmid18639546en_HK
dc.identifier.scopuseid_2-s2.0-52349118209en_HK
dc.identifier.hkuros161741en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52349118209&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume87en_HK
dc.identifier.issue4en_HK
dc.identifier.spage334en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:000259802100006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridFu, Ql=23388762000en_HK
dc.identifier.scopusauthoridGuo, H=12774450700en_HK
dc.identifier.scopusauthoridSo, Kf=34668391300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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