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Article: MR study of postnatal development of myocardial structure and left ventricular function

TitleMR study of postnatal development of myocardial structure and left ventricular function
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 1, p. 47-53 How to Cite?
AbstractPurpose: To investigate postnatal development of left ventricular (LV) cardiac function and myocardium structure. Materials and Methods: In vivo cardiac MR and ex vivo diffusion tensor imaging (DTI) were performed in normal Sprague-Dawley rats at postnatal day 2, 4, 7, 14, 21, 28, and 56 (N = 6 per group). Results: Morphologically, LV size increased with age. Functionally, stroke volume and cardiac output increased. Heart rate increased gradually and became stable after day 14. On average, ejection fraction increased within the first 4 days, decreased at day 7, gradually increased until day 21, and became stable afterward. Structurally, double-helical myocardial structure was found as early as day 2. Myocardial fiber parameters, described by fractional anisotropy, mean apparent diffusion coefficient, and axial diffusivity, increased within the first 4 days. Then radial diffusivity increased until day 7 while other parameters decreased up to day 56. Conclusion: Postnatal heart development was documented by MRI. DTI findings are in agreement with the two known stages of early postnatal growth: hyperplasia and hypertrophy. These results can serve as the baselines for study of postnatal heart developmental abnormalities. They also demonstrate the ability of DTI to reveal microstructural alterations in myocardium. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58733
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7794/07M
Funding Information:

Contract grant sponsor: Hong Kong Research Grant Council: Contract grant number: GRF HKU 7794/07M.

References

 

DC FieldValueLanguage
dc.contributor.authorWu, Yen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:35:57Z-
dc.date.available2010-05-31T03:35:57Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 30 n. 1, p. 47-53en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58733-
dc.description.abstractPurpose: To investigate postnatal development of left ventricular (LV) cardiac function and myocardium structure. Materials and Methods: In vivo cardiac MR and ex vivo diffusion tensor imaging (DTI) were performed in normal Sprague-Dawley rats at postnatal day 2, 4, 7, 14, 21, 28, and 56 (N = 6 per group). Results: Morphologically, LV size increased with age. Functionally, stroke volume and cardiac output increased. Heart rate increased gradually and became stable after day 14. On average, ejection fraction increased within the first 4 days, decreased at day 7, gradually increased until day 21, and became stable afterward. Structurally, double-helical myocardial structure was found as early as day 2. Myocardial fiber parameters, described by fractional anisotropy, mean apparent diffusion coefficient, and axial diffusivity, increased within the first 4 days. Then radial diffusivity increased until day 7 while other parameters decreased up to day 56. Conclusion: Postnatal heart development was documented by MRI. DTI findings are in agreement with the two known stages of early postnatal growth: hyperplasia and hypertrophy. These results can serve as the baselines for study of postnatal heart developmental abnormalities. They also demonstrate the ability of DTI to reveal microstructural alterations in myocardium. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshCardiac Output - physiologyen_HK
dc.subject.meshDiffusionen_HK
dc.subject.meshDiffusion Magnetic Resonance Imaging - methodsen_HK
dc.subject.meshHeart - anatomy & histology - growth & development - physiologyen_HK
dc.subject.meshHeart Rate - physiologyen_HK
dc.subject.meshHeart Ventricles - anatomy & histologyen_HK
dc.subject.meshImage Processing, Computer-Assisted - methodsen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStroke Volume - physiologyen_HK
dc.subject.meshVentricular Function, Left - physiologyen_HK
dc.titleMR study of postnatal development of myocardial structure and left ventricular functionen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21814en_HK
dc.identifier.pmid19466715-
dc.identifier.scopuseid_2-s2.0-67650067324en_HK
dc.identifier.hkuros161960en_HK
dc.identifier.hkuros178256-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650067324&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue1en_HK
dc.identifier.spage47en_HK
dc.identifier.epage53en_HK
dc.identifier.isiWOS:000267452600007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, Y=8940205500en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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