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Article: In vivo MRI evaluation of anabolic steroid precursor growth effects in a guinea pig model

TitleIn vivo MRI evaluation of anabolic steroid precursor growth effects in a guinea pig model
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroids
Citation
Steroids, 2009, v. 74 n. 8, p. 684-693 How to Cite?
AbstractAnabolic steroids are widely used to increase skeletal muscle (SM) mass and improve physical performance. Some dietary supplements also include potent steroid precursors or active steroid analogs such as nandrolone. Our previous study reported the anabolic steroid effects on SM in a castrated guinea pig model with SM measured using a highly quantitative magnetic resonance imaging (MRI) protocol. The aim of the current study was to apply this animal model and in vivo MRI protocol to evaluate the growth effects of four widely used over-the-counter testosterone and nandrolone precursors: 4-androstene-3 17-dione (androstenedione), 4-androstene-3β 17β-diol (4-androsdiol), 19-nor-4-androstene-3β-17β-diol (bolandiol) and 19-nor-4-androstene-3 17-dione (19-norandrostenedione). The results showed that providing precursor to castrated male guinea pigs led to plasma steroid levels sufficient to maintain normal SM growth. The anabolic growth effects of these specific precursors on individual and total muscle volumes, sexual organs, and total adipose tissue over a 10-week treatment period, in comparison with those in the respective positive control testosterone and nandrolone groups, were documented quantitatively by MRI. © 2009 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58725
ISSN
2015 Impact Factor: 2.513
2015 SCImago Journal Rankings: 0.876
ISI Accession Number ID
Funding AgencyGrant Number
US Dept. of InteriorNBCHC010064
Funding Information:

The authors thank Kenny Hess, Fan Hua, Xingsheng Wang, and BK Ooi at Columbia University for technical assistance in animal procedures, handling and image analysis. This work was supported in part by US Dept. of Interior (NBCHC010064).

References

 

DC FieldValueLanguage
dc.contributor.authorTang, Hen_HK
dc.contributor.authorVasselli, JRen_HK
dc.contributor.authorTong, Cen_HK
dc.contributor.authorHeymsfield, SBen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:35:48Z-
dc.date.available2010-05-31T03:35:48Z-
dc.date.issued2009en_HK
dc.identifier.citationSteroids, 2009, v. 74 n. 8, p. 684-693en_HK
dc.identifier.issn0039-128Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/58725-
dc.description.abstractAnabolic steroids are widely used to increase skeletal muscle (SM) mass and improve physical performance. Some dietary supplements also include potent steroid precursors or active steroid analogs such as nandrolone. Our previous study reported the anabolic steroid effects on SM in a castrated guinea pig model with SM measured using a highly quantitative magnetic resonance imaging (MRI) protocol. The aim of the current study was to apply this animal model and in vivo MRI protocol to evaluate the growth effects of four widely used over-the-counter testosterone and nandrolone precursors: 4-androstene-3 17-dione (androstenedione), 4-androstene-3β 17β-diol (4-androsdiol), 19-nor-4-androstene-3β-17β-diol (bolandiol) and 19-nor-4-androstene-3 17-dione (19-norandrostenedione). The results showed that providing precursor to castrated male guinea pigs led to plasma steroid levels sufficient to maintain normal SM growth. The anabolic growth effects of these specific precursors on individual and total muscle volumes, sexual organs, and total adipose tissue over a 10-week treatment period, in comparison with those in the respective positive control testosterone and nandrolone groups, were documented quantitatively by MRI. © 2009 Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroidsen_HK
dc.relation.ispartofSteroidsen_HK
dc.rightsSteroids. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdipose Tissue - drug effects - metabolismen_HK
dc.subject.meshAnabolic Agents - administration & dosage - chemistry - pharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBody Weight - drug effectsen_HK
dc.subject.meshCapsulesen_HK
dc.subject.meshCastrationen_HK
dc.subject.meshDietary Supplementsen_HK
dc.subject.meshDimethylpolysiloxanes - chemistryen_HK
dc.subject.meshGenitalia, Male - drug effects - growth & developmenten_HK
dc.subject.meshGuinea Pigsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshMuscle, Skeletal - drug effects - growth & developmenten_HK
dc.subject.meshNandrolone - blooden_HK
dc.subject.meshSteroids - administration & dosage - chemistry - pharmacologyen_HK
dc.subject.meshTestosterone - blooden_HK
dc.titleIn vivo MRI evaluation of anabolic steroid precursor growth effects in a guinea pig modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-128X&volume=74&spage=684&epage=693&date=2009&atitle=In+vivo+MRI+evaluation+of+anabolic+steroid+precursor+growth+effects+in+a+guinea+pig+modelen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.steroids.2009.02.012en_HK
dc.identifier.pmid19463691-
dc.identifier.scopuseid_2-s2.0-67349226890en_HK
dc.identifier.hkuros161949en_HK
dc.identifier.hkuros177030-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349226890&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue8en_HK
dc.identifier.spage684en_HK
dc.identifier.epage693en_HK
dc.identifier.isiWOS:000267236100009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridVasselli, JR=7003912429en_HK
dc.identifier.scopusauthoridTong, C=35796514400en_HK
dc.identifier.scopusauthoridHeymsfield, SB=36038154600en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike5026517-

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