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Article: MRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries

TitleMRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries
Authors
KeywordsDiffusion tensor imaging
Neurotoxicity
Proton magnetic resonance spectroscopy
Radiotherapy
Rat brain
White matter
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 29 n. 5, p. 1013-1020 How to Cite?
AbstractPurpose: To evaluate the late effects of radiation-induced damages in the rat brain by means of in vivo multipara- metric MRI. Materials and Methods: The right hemibrains of seven Sprague-Dawley rats were irradiated with a highly colli- mated 6 MV photon beam at a single dose of approximately 28 Gy. Diffusion tensor imaging (DTI), proton MR spectros- copy (1H-MRS), T2-weighted imaging, and T1-weighted im- aging were performed to the same animals 12 months after radiation treatment. Results: Compared with the contralateral side, a signifi- cantly higher percentage decrease in fractional anisotropy was observed in the ipsilateral fimbria of hippocampus (29%) than the external capsule (8%) in DTI, indicating the selective vulnerability of fimbria to radiation treatment. Furthermore, in 1H-MRS, significantly higher choline, glu- tamate, lactate, and taurine peaks by 24%, 25%, 87%, and 58%, respectively, were observed relative to creatine in the ipsilateral brain. Postmortem histology confirmed these white matter degradations as well as glial fibrillary acidic protein and glutamine synthetase immunoreactivity in- crease in the ipsilateral brain. Conclusion: The microstructural and metabolic changes in late radiation-induced brain injuries were documented in vivo. These multiparametric MRI measurements may help understand the white matter changes and neurotoxicity upon radiation treatment in a single setting. © 2009.
Persistent Identifierhttp://hdl.handle.net/10722/58645
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorKhong, PIen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorCai, KXen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-05-31T03:34:14Z-
dc.date.available2010-05-31T03:34:14Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 29 n. 5, p. 1013-1020en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58645-
dc.description.abstractPurpose: To evaluate the late effects of radiation-induced damages in the rat brain by means of in vivo multipara- metric MRI. Materials and Methods: The right hemibrains of seven Sprague-Dawley rats were irradiated with a highly colli- mated 6 MV photon beam at a single dose of approximately 28 Gy. Diffusion tensor imaging (DTI), proton MR spectros- copy (1H-MRS), T2-weighted imaging, and T1-weighted im- aging were performed to the same animals 12 months after radiation treatment. Results: Compared with the contralateral side, a signifi- cantly higher percentage decrease in fractional anisotropy was observed in the ipsilateral fimbria of hippocampus (29%) than the external capsule (8%) in DTI, indicating the selective vulnerability of fimbria to radiation treatment. Furthermore, in 1H-MRS, significantly higher choline, glu- tamate, lactate, and taurine peaks by 24%, 25%, 87%, and 58%, respectively, were observed relative to creatine in the ipsilateral brain. Postmortem histology confirmed these white matter degradations as well as glial fibrillary acidic protein and glutamine synthetase immunoreactivity in- crease in the ipsilateral brain. Conclusion: The microstructural and metabolic changes in late radiation-induced brain injuries were documented in vivo. These multiparametric MRI measurements may help understand the white matter changes and neurotoxicity upon radiation treatment in a single setting. © 2009.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectDiffusion tensor imagingen_HK
dc.subjectNeurotoxicityen_HK
dc.subjectProton magnetic resonance spectroscopyen_HK
dc.subjectRadiotherapyen_HK
dc.subjectRat brainen_HK
dc.subjectWhite matteren_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - metabolism - pathology - radiation effectsen_HK
dc.subject.meshBrain Injuries - etiology - metabolism - pathologyen_HK
dc.subject.meshGene Expression Regulation - radiation effectsen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMagnetic Resonance Spectroscopy - methodsen_HK
dc.subject.meshNeurotransmitter Agents - analysisen_HK
dc.subject.meshRadiation Injuries - metabolism - pathologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTissue Distributionen_HK
dc.titleMRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuriesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=29&spage=1013&epage=1020&date=2009&atitle=MRI+of+late+microstructural+and+metabolic+alterations+in+radiation-induced+brain+injuriesen_HK
dc.identifier.emailKhong, PI:plkhong@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PI=rp00467en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21736en_HK
dc.identifier.pmid19388094-
dc.identifier.scopuseid_2-s2.0-66149109627en_HK
dc.identifier.hkuros155572en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66149109627&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1013en_HK
dc.identifier.epage1020en_HK
dc.identifier.isiWOS:000265621200003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridKhong, PI=7006693233en_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridCai, KX=26321372500en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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