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Article: Increased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumors

TitleIncreased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumors
Authors
KeywordsAnnexin I
CNE2
Drug resistant gene
Nasopharyngeal carcinoma
Issue Date2009
PublisherWiley - V C H Verlag GmbH & Co KGaA
Citation
Proteomics - Clinical Applications, 2009, v. 3 n. 6, p. 654-662 How to Cite?
AbstractAdjuvant chemotherapy alongside radiotherapy is one of the effective therapies in nasopharyngeal carcinoma (NPC) treatment. However, the appearance of drug resistance is a major obstacle for anti-cancer chemotherapy and often causes failure of the chemotherapy. In this study, a drug-resistant gene annexin I (ANX-I) was identified by comparing differentially expressed proteins between a cisplatin (CDDP)-resistant NPC cell line CNE2-CDDP and parental CNE2 cells using 2-DE. When ANX-I was transfected into CNE2 cells, the CDDP resistance of CNE2 cells was dramatically increased. The drug-resistant ability of ANX-I was demonstrated by both in vitro and in vivo assays. The association of ANX-I expression with clinical features was also investigated. Increased expression of ANX-I was significantly associated with disease relapse in NPC (p<0.05). In breast and gastric cancer, increased expression of ANX-I was significantly associated with drug resistance (p<0.001) and poor prognosis (p<0.001), respectively. Taken together, our findings suggest that ANX-I plays an important role in drug resistance. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/58619
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant CouncilHKU 7393/04M
Major State Basic Research Program of China2006CB910104
Sun Yat-Sen University85000-3171311
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Funding Information:

This work was supported by Research Grant Council Grant (HKU 7393/04M), the Major State Basic Research Program of China (2006CB910104), Sun Yat-Sen University "Hundred Talents Program" (85000-3171311), and the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChow, BHYen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorZhang, MYen_HK
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorBi, Jen_HK
dc.contributor.authorMa, NFen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorLoo, WTYen_HK
dc.contributor.authorFung, JMWen_HK
dc.contributor.authorFu, Len_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-05-31T03:33:38Z-
dc.date.available2010-05-31T03:33:38Z-
dc.date.issued2009en_HK
dc.identifier.citationProteomics - Clinical Applications, 2009, v. 3 n. 6, p. 654-662en_HK
dc.identifier.issn1862-8346en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58619-
dc.description.abstractAdjuvant chemotherapy alongside radiotherapy is one of the effective therapies in nasopharyngeal carcinoma (NPC) treatment. However, the appearance of drug resistance is a major obstacle for anti-cancer chemotherapy and often causes failure of the chemotherapy. In this study, a drug-resistant gene annexin I (ANX-I) was identified by comparing differentially expressed proteins between a cisplatin (CDDP)-resistant NPC cell line CNE2-CDDP and parental CNE2 cells using 2-DE. When ANX-I was transfected into CNE2 cells, the CDDP resistance of CNE2 cells was dramatically increased. The drug-resistant ability of ANX-I was demonstrated by both in vitro and in vivo assays. The association of ANX-I expression with clinical features was also investigated. Increased expression of ANX-I was significantly associated with disease relapse in NPC (p<0.05). In breast and gastric cancer, increased expression of ANX-I was significantly associated with drug resistance (p<0.001) and poor prognosis (p<0.001), respectively. Taken together, our findings suggest that ANX-I plays an important role in drug resistance. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaAen_HK
dc.relation.ispartofProteomics - Clinical Applicationsen_HK
dc.subjectAnnexin Ien_HK
dc.subjectCNE2en_HK
dc.subjectDrug resistant geneen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.titleIncreased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1862-8346&volume=3&spage=654&epage=662&date=2009&atitle=Increased+expression+of+annexin+I+is+associated+with+drug-resistance+in+nasopharyngeal+carcinoma+and+other+solid+tumors.en_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailFu, L: gracelfu@hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityFu, L=rp01435en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/prca.200800164en_HK
dc.identifier.scopuseid_2-s2.0-70350097223en_HK
dc.identifier.hkuros157424en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350097223&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue6en_HK
dc.identifier.spage654en_HK
dc.identifier.epage662en_HK
dc.identifier.isiWOS:000267915300002-
dc.publisher.placeGermanyen_HK
dc.relation.projectCharacterization of roles of a novel oncogene ALC-1 in the development of hepatocellular carcinoma-
dc.identifier.scopusauthoridChow, BHY=35199637300en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridZhang, MY=8852350800en_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridBi, J=7103093361en_HK
dc.identifier.scopusauthoridMa, NF=35731661400en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridLoo, WTY=7003567474en_HK
dc.identifier.scopusauthoridFung, JMW=23469161200en_HK
dc.identifier.scopusauthoridFu, L=22979236700en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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