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Article: Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma

TitleExpression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma
Authors
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 2009, v. 112 n. 2, p. 314-318 How to Cite?
AbstractObjectives: Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. Methods: In this study, we examined expression of EIF-5A2, using immunohistochemistry, in 30 normal ovaries, 30 ovarian cystadenomas, 30 borderline ovarian tumors and 110 ovarian carcinomas. The amplification status of eIF-5A2 in each ovarian carcinoma was assessed by fluorescence in situ hybridization. Results: Overexpression of EIF-5A2 was detected in none of the normal ovaries, 7% cystadenomas, 30% borderline tumors, and 53% invasive ovarian carcinomas, respectively. Amplification of eIF-5A2 was detected in 16% of informative ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between overexpression of EIF-5A2 and the tumors ascending grade, later pT/pN and FIGO stages, as well as increased positive rate of Ki-67 (p < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of overexpression of EIF-5A2 with shortened patient survival (mean 39.0 months vs 69.5 months, p < 0.001) was demonstrated. Importantly, EIF-5A2 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.043). Conclusions: These findings suggest that increased expression of EIF-5A2 in ovarian carcinoma may represent an acquired malignant phenotypic feature of tumor cells, and the overexpression of EIF-5A2, as detected by immunohistochemistry, is an independent molecular marker for shortened survival time of patients with ovarian carcinoma. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58612
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
30772475
Key Special Project of Guangdong Science and technology Agency2005A30801001
Hong Kong Research Grant Council GrantHKU7656/07M
Funding Information:

This study was supported in part by the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (No.30772334 and 30772475), Key Special Project of Guangdong Science and technology Agency (2005A30801001) and Hong Kong Research Grant Council Grant (HKU7656/07M).

References

 

DC FieldValueLanguage
dc.contributor.authorYang, GFen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorLiu, JHen_HK
dc.contributor.authorLuo, JHen_HK
dc.contributor.authorLi, LJen_HK
dc.contributor.authorHua, WFen_HK
dc.contributor.authorWu, HMen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-05-31T03:33:30Z-
dc.date.available2010-05-31T03:33:30Z-
dc.date.issued2009en_HK
dc.identifier.citationGynecologic Oncology, 2009, v. 112 n. 2, p. 314-318en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58612-
dc.description.abstractObjectives: Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. Methods: In this study, we examined expression of EIF-5A2, using immunohistochemistry, in 30 normal ovaries, 30 ovarian cystadenomas, 30 borderline ovarian tumors and 110 ovarian carcinomas. The amplification status of eIF-5A2 in each ovarian carcinoma was assessed by fluorescence in situ hybridization. Results: Overexpression of EIF-5A2 was detected in none of the normal ovaries, 7% cystadenomas, 30% borderline tumors, and 53% invasive ovarian carcinomas, respectively. Amplification of eIF-5A2 was detected in 16% of informative ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between overexpression of EIF-5A2 and the tumors ascending grade, later pT/pN and FIGO stages, as well as increased positive rate of Ki-67 (p < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of overexpression of EIF-5A2 with shortened patient survival (mean 39.0 months vs 69.5 months, p < 0.001) was demonstrated. Importantly, EIF-5A2 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.043). Conclusions: These findings suggest that increased expression of EIF-5A2 in ovarian carcinoma may represent an acquired malignant phenotypic feature of tumor cells, and the overexpression of EIF-5A2, as detected by immunohistochemistry, is an independent molecular marker for shortened survival time of patients with ovarian carcinoma. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCystadenoma - genetics - metabolism - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshKi-67 Antigen - biosynthesisen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOvarian Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshParaffin Embeddingen_HK
dc.subject.meshPeptide Initiation Factors - biosynthesis - geneticsen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTumor Markers, Biological - biosynthesis - geneticsen_HK
dc.subject.meshYoung Adulten_HK
dc.titleExpression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=112&spage=314&epage=318&date=2009&atitle=Expression+and+amplification+of+eIF-5A2+in+human+epithelial+ovarian+tumors+and+overexpression+of+EIF-5A2+is+a+new+independent+predictor+of+outcome+in+patients+with+ovarian+carcinomaen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygyno.2008.10.024en_HK
dc.identifier.pmid19054548en_HK
dc.identifier.scopuseid_2-s2.0-58149485132en_HK
dc.identifier.hkuros156537en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149485132&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume112en_HK
dc.identifier.issue2en_HK
dc.identifier.spage314en_HK
dc.identifier.epage318en_HK
dc.identifier.isiWOS:000263148400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, GF=16064823400en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridLiu, JH=16042459100en_HK
dc.identifier.scopusauthoridLuo, JH=7404183419en_HK
dc.identifier.scopusauthoridLi, LJ=36065125900en_HK
dc.identifier.scopusauthoridHua, WF=24401204900en_HK
dc.identifier.scopusauthoridWu, HM=25958596100en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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