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Article: In search of liver cancer stem cells

TitleIn search of liver cancer stem cells
Authors
KeywordsALDH
CD133
HCC
Liver cancer stem cells
Liver regeneration
Issue Date2008
PublisherHumana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/molecular%2C+cell+and+stem+cell+biology/journal/12015
Citation
Stem Cell Reviews, 2008, v. 4 n. 3, p. 179-192 How to Cite?
AbstractRecent research efforts in stem cell and cancer biology have put forth a "stem cell model of carcinogenesis" which stipulates that the capability to maintain tumor formation and growth specifically resides in a small population of cells called cancer stem cells. The stem cell-like characteristics of these cells, including their ability to self-renew and differentiate; and their limited number within the bulk of the tumor mass, are believed to account for their capability to escape conventional therapies. In the past few years, the hypothesis of stem cell-driven tumorigenesis in liver cancer has received substantial support from the recent ability to identify and isolate a subpopulation of liver cancer cells that is not only able to initiate tumor growth, but also serially establish themselves as tumor xenografts with high efficiency and consistency. In this review, stem cell biology that contributes to explain tumor development in the particular context of liver cancer will be discussed. We will begin by briefly considering the knowledge available on normal liver stem cells and their role in tissue renewal and regeneration. We will then summarize the current scientific knowledge of liver cancer stem cells, discuss their relevance to the diagnosis and treatment of the disease and consider the outstanding challenges and potential opportunities that lie ahead of us. © 2008 Humana Press.
Persistent Identifierhttp://hdl.handle.net/10722/58610
ISSN
2015 Impact Factor: 3.111
2015 SCImago Journal Rankings: 1.424
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Sen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-05-31T03:33:28Z-
dc.date.available2010-05-31T03:33:28Z-
dc.date.issued2008en_HK
dc.identifier.citationStem Cell Reviews, 2008, v. 4 n. 3, p. 179-192en_HK
dc.identifier.issn1550-8943en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58610-
dc.description.abstractRecent research efforts in stem cell and cancer biology have put forth a "stem cell model of carcinogenesis" which stipulates that the capability to maintain tumor formation and growth specifically resides in a small population of cells called cancer stem cells. The stem cell-like characteristics of these cells, including their ability to self-renew and differentiate; and their limited number within the bulk of the tumor mass, are believed to account for their capability to escape conventional therapies. In the past few years, the hypothesis of stem cell-driven tumorigenesis in liver cancer has received substantial support from the recent ability to identify and isolate a subpopulation of liver cancer cells that is not only able to initiate tumor growth, but also serially establish themselves as tumor xenografts with high efficiency and consistency. In this review, stem cell biology that contributes to explain tumor development in the particular context of liver cancer will be discussed. We will begin by briefly considering the knowledge available on normal liver stem cells and their role in tissue renewal and regeneration. We will then summarize the current scientific knowledge of liver cancer stem cells, discuss their relevance to the diagnosis and treatment of the disease and consider the outstanding challenges and potential opportunities that lie ahead of us. © 2008 Humana Press.en_HK
dc.languageengen_HK
dc.publisherHumana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/molecular%2C+cell+and+stem+cell+biology/journal/12015en_HK
dc.relation.ispartofStem Cell Reviewsen_HK
dc.subjectALDHen_HK
dc.subjectCD133en_HK
dc.subjectHCCen_HK
dc.subjectLiver cancer stem cellsen_HK
dc.subjectLiver regenerationen_HK
dc.subject.meshAldehyde Dehydrogenase - metabolismen_HK
dc.subject.meshAntigens, CD - metabolismen_HK
dc.subject.meshGlycoproteins - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - metabolism - pathology - physiopathologyen_HK
dc.subject.meshLiver Neoplasms - metabolism - pathologyen_HK
dc.subject.meshLiver Regeneration - physiologyen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshNeoplastic Stem Cells - metabolism - pathologyen_HK
dc.subject.meshPeptides - metabolismen_HK
dc.subject.meshStem Cells - cytology - metabolismen_HK
dc.titleIn search of liver cancer stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1550-8943&volume=4&spage=179&epage=192&date=2008&atitle=In+search+of+liver+cancer+stem+cellsen_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12015-008-9035-zen_HK
dc.identifier.pmid18663610-
dc.identifier.scopuseid_2-s2.0-58149200071en_HK
dc.identifier.hkuros146066en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149200071&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage179en_HK
dc.identifier.epage192en_HK
dc.identifier.eissn1558-6804-
dc.identifier.isiWOS:000259291300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.citeulike3632825-

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