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Article: Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
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TitleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
 
AuthorsJiang, L2 4
Chen, Y4
Chan, Cy4
Wang, X4
Lin, L3
He, Ml4
Lin, MCM1
Yew, DT4
Sung, JJY4
Li, JC2
Kung, Hf4
 
KeywordsApoptosis
Chemosensitivity
Pancreatic cancer
Stathmin
TIEG1
 
Issue Date2009
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2009, v. 274 n. 1, p. 101-108 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2008.09.017
 
AbstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0304-3835
2013 Impact Factor: 5.016
 
DOIhttp://dx.doi.org/10.1016/j.canlet.2008.09.017
 
ISI Accession Number IDWOS:000262735500014
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCUHK7422/03M
2140564
467507
Institute of Health Sciences
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Chinese University of Hong Kong2041270
2041345
Funding Information:

This work was Supported by grants from Hong Kong Research Grant Council (CUHK7422/03M, 2140564 and 467507 to H.F.K.), Li Ka Shing Institute of Health Sciences to H.FK, the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131 to H.F.K), and Direct Grants from the Chinese University of Hong Kong (2041270 and 2041345) to Y.C.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorJiang, L
 
dc.contributor.authorChen, Y
 
dc.contributor.authorChan, Cy
 
dc.contributor.authorWang, X
 
dc.contributor.authorLin, L
 
dc.contributor.authorHe, Ml
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorYew, DT
 
dc.contributor.authorSung, JJY
 
dc.contributor.authorLi, JC
 
dc.contributor.authorKung, Hf
 
dc.date.accessioned2010-05-31T03:30:55Z
 
dc.date.available2010-05-31T03:30:55Z
 
dc.date.issued2009
 
dc.description.abstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2009, v. 274 n. 1, p. 101-108 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2008.09.017
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2008.09.017
 
dc.identifier.epage108
 
dc.identifier.hkuros153177
 
dc.identifier.isiWOS:000262735500014
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCUHK7422/03M
2140564
467507
Institute of Health Sciences
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Chinese University of Hong Kong2041270
2041345
Funding Information:

This work was Supported by grants from Hong Kong Research Grant Council (CUHK7422/03M, 2140564 and 467507 to H.F.K.), Li Ka Shing Institute of Health Sciences to H.FK, the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131 to H.F.K), and Direct Grants from the Chinese University of Hong Kong (2041270 and 2041345) to Y.C.

 
dc.identifier.issn0304-3835
2013 Impact Factor: 5.016
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid18930345
 
dc.identifier.scopuseid_2-s2.0-57749084479
 
dc.identifier.spage101
 
dc.identifier.urihttp://hdl.handle.net/10722/58473
 
dc.identifier.volume274
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.
 
dc.subjectApoptosis
 
dc.subjectChemosensitivity
 
dc.subjectPancreatic cancer
 
dc.subjectStathmin
 
dc.subjectTIEG1
 
dc.titleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
 
dc.typeArticle
 
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<contributor.author>Yew, DT</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Zhejiang University
  3. Hong Kong Polytechnic University
  4. Chinese University of Hong Kong