Article: Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells

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TitleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
AuthorsJiang, L2 4
Chen, Y4
Chan, Cy4
Wang, X4
Lin, L3
He, Ml4
Lin, MCM1
Yew, DT4
Sung, JJY4
Li, JC2
Kung, Hf4
KeywordsApoptosis
Chemosensitivity
Pancreatic cancer
Stathmin
TIEG1
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
CitationCancer Letters, 2009, v. 274 n. 1, p. 101-108 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2008.09.017
AbstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
DOIhttp://dx.doi.org/10.1016/j.canlet.2008.09.017
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorJiang, L
dc.contributor.authorChen, Y
dc.contributor.authorChan, Cy
dc.contributor.authorWang, X
dc.contributor.authorLin, L
dc.contributor.authorHe, Ml
dc.contributor.authorLin, MCM
dc.contributor.authorYew, DT
dc.contributor.authorSung, JJY
dc.contributor.authorLi, JC
dc.contributor.authorKung, Hf
dc.date.accessioned2010-05-31T03:30:55Z
dc.date.available2010-05-31T03:30:55Z
dc.date.issued2009
dc.description.abstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Letters, 2009, v. 274 n. 1, p. 101-108 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2008.09.017
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2008.09.017
dc.identifier.epage108
dc.identifier.hkuros153177
dc.identifier.isiWOS:000262735500014
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCUHK7422/03M
2140564
467507
Institute of Health Sciences
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Chinese University of Hong Kong2041270
2041345
Funding Information:

This work was Supported by grants from Hong Kong Research Grant Council (CUHK7422/03M, 2140564 and 467507 to H.F.K.), Li Ka Shing Institute of Health Sciences to H.FK, the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131 to H.F.K), and Direct Grants from the Chinese University of Hong Kong (2041270 and 2041345) to Y.C.

dc.identifier.issn0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid18930345
dc.identifier.scopuseid_2-s2.0-57749084479
dc.identifier.spage101
dc.identifier.urihttp://hdl.handle.net/10722/58473
dc.identifier.volume274
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
dc.publisher.placeIreland
dc.relation.ispartofCancer Letters
dc.relation.referencesReferences in Scopus
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.
dc.subjectApoptosis
dc.subjectChemosensitivity
dc.subjectPancreatic cancer
dc.subjectStathmin
dc.subjectTIEG1
dc.titleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Zhejiang University
  3. Hong Kong Polytechnic University
  4. Chinese University of Hong Kong