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Article: Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells

TitleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
Authors
Jiang, LChen, YChan, CyWang, XLin, LHe, MlLin, MCMYew, DTSung, JJYLi, JCKung, Hf
KeywordsApoptosis
Chemosensitivity
Pancreatic cancer
Stathmin
TIEG1
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2009, v. 274 n. 1, p. 101-108 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2008.09.017
AbstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58473
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000262735500014
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCUHK7422/03M
2140564
467507
Institute of Health Sciences
Foundation of Guangzhou Science and Technology Bureau2005Z1-E0131
Chinese University of Hong Kong2041270
2041345
Funding Information:

This work was Supported by grants from Hong Kong Research Grant Council (CUHK7422/03M, 2140564 and 467507 to H.F.K.), Li Ka Shing Institute of Health Sciences to H.FK, the Foundation of Guangzhou Science and Technology Bureau (2005Z1-E0131 to H.F.K), and Direct Grants from the Chinese University of Hong Kong (2041270 and 2041345) to Y.C.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorJiang, Len_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChan, Cyen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorLin, Len_HK
dc.contributor.authorHe, Mlen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorYew, DTen_HK
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorLi, JCen_HK
dc.contributor.authorKung, Hfen_HK
dc.date.accessioned2010-05-31T03:30:55Z-
dc.date.available2010-05-31T03:30:55Z-
dc.date.issued2009en_HK
dc.identifier.citationCancer Letters, 2009, v. 274 n. 1, p. 101-108en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58473-
dc.description.abstractTransforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectApoptosisen_HK
dc.subjectChemosensitivityen_HK
dc.subjectPancreatic canceren_HK
dc.subjectStathminen_HK
dc.subjectTIEG1en_HK
dc.titleDown-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=274&issue=1&spage=101&epage=8&date=2008&atitle=Down-regulation+of+Stathmin+is+Required+for+TGF-beta+Inducible+Early+Gene+1+Induced+Growth+Inhibition+of+Pancreatic+Cancer+Cellsen_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2008.09.017en_HK
dc.identifier.pmid18930345-
dc.identifier.scopuseid_2-s2.0-57749084479en_HK
dc.identifier.hkuros153177en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57749084479&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume274en_HK
dc.identifier.issue1en_HK
dc.identifier.spage101en_HK
dc.identifier.epage108en_HK
dc.identifier.isiWOS:000262735500014-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridJiang, L=37000894400en_HK
dc.identifier.scopusauthoridChen, Y=24075600300en_HK
dc.identifier.scopusauthoridChan, Cy=22033276600en_HK
dc.identifier.scopusauthoridWang, X=35235704600en_HK
dc.identifier.scopusauthoridLin, L=55202920600en_HK
dc.identifier.scopusauthoridHe, Ml=35080389700en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridYew, DT=7007034694en_HK
dc.identifier.scopusauthoridSung, JJY=35405352400en_HK
dc.identifier.scopusauthoridLi, JC=25722607300en_HK
dc.identifier.scopusauthoridKung, Hf=7402514190en_HK
dc.identifier.issnl0304-3835-

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