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Article: BODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells

TitleBODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2009, v. 11 n. 9, p. 1887-1890 How to Cite?
AbstractA fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO-). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-γ (IFN-γ), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.©2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/58467
ISSN
2015 Impact Factor: 6.732
2015 SCImago Journal Rankings: 3.187
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Hong Kong ResearchHKU7060/05P
University Postdoctoral Fellowship
Funding Information:

This work was supported by the University of Hong Kong and the Hong Kong Research Grants Council (HKU7060/05P). Z.N.S. is a recipient of a University Postdoctoral Fellowship. We also thank the Faculty of Medicine at HKU for the Confocal Microscopy and Live Cell Imaging Facility.

References

 

DC FieldValueLanguage
dc.contributor.authorSun, ZNen_HK
dc.contributor.authorWang, HLen_HK
dc.contributor.authorLiu, FQen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorYang, Den_HK
dc.date.accessioned2010-05-31T03:30:49Z-
dc.date.available2010-05-31T03:30:49Z-
dc.date.issued2009en_HK
dc.identifier.citationOrganic Letters, 2009, v. 11 n. 9, p. 1887-1890en_HK
dc.identifier.issn1523-7060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58467-
dc.description.abstractA fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO-). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-γ (IFN-γ), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.©2009 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.htmlen_HK
dc.relation.ispartofOrganic Lettersen_HK
dc.titleBODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1523-7060&volume=11&spage=1887&epage=1890&date=2009&atitle=BODIPY-Based+Fluorescent+Probe+for+Peroxynitrite+Detection+and+Imaging+in+Living+Cellsen_HK
dc.identifier.emailSun, ZN: znsun@hku.hken_HK
dc.identifier.emailChen, Y: ychenc@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.emailYang, D: yangdan@hku.hken_HK
dc.identifier.authoritySun, ZN=rp00782en_HK
dc.identifier.authorityChen, Y=rp01318en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ol900279zen_HK
dc.identifier.pmid19331349-
dc.identifier.scopuseid_2-s2.0-65549139801en_HK
dc.identifier.hkuros156235en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65549139801&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1887en_HK
dc.identifier.epage1890en_HK
dc.identifier.isiWOS:000265529000006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSun, ZN=25029021500en_HK
dc.identifier.scopusauthoridWang, HL=35604926700en_HK
dc.identifier.scopusauthoridLiu, FQ=36067266700en_HK
dc.identifier.scopusauthoridChen, Y=36463185300en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK

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