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Article: Ion desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: Desorption mechanism(s) and the design of SALDI substrates

TitleIon desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: Desorption mechanism(s) and the design of SALDI substrates
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ac
Citation
Analytical Chemistry, 2009, v. 81 n. 12, p. 4720-4729 How to Cite?
AbstractIon desorption efficiency and internal energy transfer were probed and correlated in carbon-based surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using benzylpyridinium (BP) salt as the thermometer chemical. In a SALDI-MS experiment with a N2 laser (at 337 nm) used as the excitation light source and with multiwalled carbon nanotubes (CNT), buckminsterfullerene (C60), nanoporous graphitic carbon (PGC), non-porous graphite particles (G), highly oriented pyrolytic graphite (HOPG), or nanodiamonds (ND) as the SALDI substrate, both the desorption efficiency in terms of ion intensity of BP and the extent of internal energy transfer to the ions are dependent on the type and size of the carbon substrates. The desorption efficiency (CNT ∼ C60 > PGC > G > HOPG > ND) in general exhibits an opposite trend to the extent of internal energy transfer (CNT < C60 ∼ PGC < G ∼ HOPG < ND), suggesting that increasing the extent of internal energy transfer in the SALDI process may not enhance the ion desorption efficiency. This phenomenon cannot be explained by a thermal desorption mechanism, and a non-thermal desorption mechanism is proposed to be involved in the SALDI process. The morphological change of the substrates after the laser irradiation and the high initial velocities of BP ions (1100-1400 ms-1) desorbed from the various carbon substrates suggest that phase transition/destruction of substrates is involved in the desorption process. Weaker bonding/interaction and/or a lower melting point of the carbon substrates favor the phase transition/ destruction of the SALDI substrates upon laser irradiation, consequently affecting the ion desorption efficiency. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/58421
ISSN
2015 Impact Factor: 5.886
2015 SCImago Journal Rankings: 2.369
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence SchemeAoE/P-10/01
Funding Information:

We acknowledge Professor Chun-Wai Tsang and Professor Kwok-Yin Wong of the Hong Kong Polytechnic University for access to the Waters micro MX MALDI-TOF mass spectrometric system. This project is supported by the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grant Council (Hong Kong SAR, China). We thank Ms. Amy S. L. Wong and Mr. Frankie Y. F. Chan of the Electron Microscope Unit of The University of Hong Kong for technical assistance in SEM measurements. We acknowledge Dr. Charlie Liu for providing the porous graphitic carbon. We also thank Dr. Daniel Kenny of Waters Corporation for providing assistance to derive the flight time of desorbed ions from the m/z value of ion peaks recorded in MALDI-TOF mass spectra.

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DC FieldValueLanguage
dc.contributor.authorTang, HWen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorLu, Wen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-05-31T03:30:00Z-
dc.date.available2010-05-31T03:30:00Z-
dc.date.issued2009en_HK
dc.identifier.citationAnalytical Chemistry, 2009, v. 81 n. 12, p. 4720-4729en_HK
dc.identifier.issn0003-2700en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58421-
dc.description.abstractIon desorption efficiency and internal energy transfer were probed and correlated in carbon-based surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using benzylpyridinium (BP) salt as the thermometer chemical. In a SALDI-MS experiment with a N2 laser (at 337 nm) used as the excitation light source and with multiwalled carbon nanotubes (CNT), buckminsterfullerene (C60), nanoporous graphitic carbon (PGC), non-porous graphite particles (G), highly oriented pyrolytic graphite (HOPG), or nanodiamonds (ND) as the SALDI substrate, both the desorption efficiency in terms of ion intensity of BP and the extent of internal energy transfer to the ions are dependent on the type and size of the carbon substrates. The desorption efficiency (CNT ∼ C60 > PGC > G > HOPG > ND) in general exhibits an opposite trend to the extent of internal energy transfer (CNT < C60 ∼ PGC < G ∼ HOPG < ND), suggesting that increasing the extent of internal energy transfer in the SALDI process may not enhance the ion desorption efficiency. This phenomenon cannot be explained by a thermal desorption mechanism, and a non-thermal desorption mechanism is proposed to be involved in the SALDI process. The morphological change of the substrates after the laser irradiation and the high initial velocities of BP ions (1100-1400 ms-1) desorbed from the various carbon substrates suggest that phase transition/destruction of substrates is involved in the desorption process. Weaker bonding/interaction and/or a lower melting point of the carbon substrates favor the phase transition/ destruction of the SALDI substrates upon laser irradiation, consequently affecting the ion desorption efficiency. © 2009 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/acen_HK
dc.relation.ispartofAnalytical Chemistryen_HK
dc.titleIon desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: Desorption mechanism(s) and the design of SALDI substratesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2700&volume=81&spage=4720&epage=4729&date=2009&atitle=Ion+Desorption+Efficiency+and+Internal+Energy+Transfer+in+Carbon-Based+Surface-Assisted+Laser+Desorption/Ionization+Mass+Spectrometry:+Desorption+Mechanism(s)+and+the+Design+of+SALDI+Substratesen_HK
dc.identifier.emailNg, KM:kwanmng@hku.hken_HK
dc.identifier.emailLu, W:luwei@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityNg, KM=rp00766en_HK
dc.identifier.authorityLu, W=rp00754en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ac8026367en_HK
dc.identifier.pmid19449861-
dc.identifier.scopuseid_2-s2.0-67249087534en_HK
dc.identifier.hkuros161504en_HK
dc.identifier.hkuros246942-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67249087534&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue12en_HK
dc.identifier.spage4720en_HK
dc.identifier.epage4729en_HK
dc.identifier.isiWOS:000266969700008-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridTang, HW=16231745000en_HK
dc.identifier.scopusauthoridNg, KM=26026091100en_HK
dc.identifier.scopusauthoridLu, W=27868087600en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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