Article: The effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues
| Title | The effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues | ||||||||||||
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| Authors | Yang, Z2 Lam, C1 Chu, IK1 Laskin, J2 | ||||||||||||
| Issue Date | 2008 | ||||||||||||
| Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jpcbfk | ||||||||||||
| Citation | Journal Of Physical Chemistry B, 2008, v. 112 n. 39, p. 12468-12478 [How to Cite?] DOI: http://dx.doi.org/10.1021/jp805226x | ||||||||||||
| Abstract | Fragmentation of protonated RVYIHPF and RVYIHPF-OMe and the corresponding radical cations was studied using time- and collision energy-resolved surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments. Peptide radical cations were produced by gas-phase fragmentation of CoIII(salen)-peptide complexes. Both the energetics and the mechanisms of dissociation of even-electron and odd-electron angiotensin III ions are quite different. Protonated molecules are much more stable toward fragmentation than the corresponding radical cations. RRKM modeling of the experimental data suggests that this stability is largely attributed to differences in threshold energies for dissociation, while activation entropies are very similar. Detailed analysis of the experimental data obtained for radical cations demonstrated the presence of two distinct structures separated by a high free-energy barrier. The two families of structures were ascribed to the canonical and zwitterionic forms of the radical cations produced in our experiments. © 2008 American Chemical Society. | ||||||||||||
| ISSN | 1520-6106 2011 Impact Factor: 3.696 2011 SCImago Journal Rankings: 0.299 | ||||||||||||
| DOI | http://dx.doi.org/10.1021/jp805226x | ||||||||||||
| ISI Accession Number ID | WOS:000259552000040
Funding Information: This study was partially supported by a grant from the Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE and partially by the University of Hong Kong and Hong Kong Research Grant Council, Special Administrative Region, China (Project No. 7018/06P). The research described in this Article was performed at the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the U.S. Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is operated by Battelle for the U.S. Department of Energy. I.K.C. and C.L. acknowledge participation in the PNNL Interfacial and Condensed Phase Summer Research Institute. We thank Mr. Tao Song (University of Hong Kong) for stimulating discussions. | ||||||||||||
| References | References in Scopus |
| dc.contributor.author | Yang, Z | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lam, C | ||||||||||||
| dc.contributor.author | Chu, IK | ||||||||||||
| dc.contributor.author | Laskin, J | ||||||||||||
| dc.date.accessioned | 2010-05-31T03:29:52Z | ||||||||||||
| dc.date.available | 2010-05-31T03:29:52Z | ||||||||||||
| dc.date.issued | 2008 | ||||||||||||
| dc.description.abstract | Fragmentation of protonated RVYIHPF and RVYIHPF-OMe and the corresponding radical cations was studied using time- and collision energy-resolved surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments. Peptide radical cations were produced by gas-phase fragmentation of CoIII(salen)-peptide complexes. Both the energetics and the mechanisms of dissociation of even-electron and odd-electron angiotensin III ions are quite different. Protonated molecules are much more stable toward fragmentation than the corresponding radical cations. RRKM modeling of the experimental data suggests that this stability is largely attributed to differences in threshold energies for dissociation, while activation entropies are very similar. Detailed analysis of the experimental data obtained for radical cations demonstrated the presence of two distinct structures separated by a high free-energy barrier. The two families of structures were ascribed to the canonical and zwitterionic forms of the radical cations produced in our experiments. © 2008 American Chemical Society. | ||||||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||||||
| dc.identifier.citation | Journal Of Physical Chemistry B, 2008, v. 112 n. 39, p. 12468-12478 [How to Cite?] DOI: http://dx.doi.org/10.1021/jp805226x | ||||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1021/jp805226x | ||||||||||||
| dc.identifier.epage | 12478 | ||||||||||||
| dc.identifier.hkuros | 155640 | ||||||||||||
| dc.identifier.isi | WOS:000259552000040
Funding Information: This study was partially supported by a grant from the Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE and partially by the University of Hong Kong and Hong Kong Research Grant Council, Special Administrative Region, China (Project No. 7018/06P). The research described in this Article was performed at the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the U.S. Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is operated by Battelle for the U.S. Department of Energy. I.K.C. and C.L. acknowledge participation in the PNNL Interfacial and Condensed Phase Summer Research Institute. We thank Mr. Tao Song (University of Hong Kong) for stimulating discussions. | ||||||||||||
| dc.identifier.issn | 1520-6106 2011 Impact Factor: 3.696 2011 SCImago Journal Rankings: 0.299 | ||||||||||||
| dc.identifier.issue | 39 | ||||||||||||
| dc.identifier.pmid | 18781717 | ||||||||||||
| dc.identifier.scopus | eid_2-s2.0-54249102284 | ||||||||||||
| dc.identifier.spage | 12468 | ||||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/58413 | ||||||||||||
| dc.identifier.volume | 112 | ||||||||||||
| dc.language | eng | ||||||||||||
| dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jpcbfk | ||||||||||||
| dc.publisher.place | United States | ||||||||||||
| dc.relation.ispartof | Journal of Physical Chemistry B | ||||||||||||
| dc.relation.references | References in Scopus | ||||||||||||
| dc.title | The effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues | ||||||||||||
| dc.type | Article |
- The University of Hong Kong
- Pacific Northwest National Laboratory