File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: The effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues
  • Basic View
  • Metadata View
  • XML View
TitleThe effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues
 
AuthorsYang, Z2
Lam, C1
Chu, IK1
Laskin, J2
 
Issue Date2008
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jpcbfk
 
CitationJournal Of Physical Chemistry B, 2008, v. 112 n. 39, p. 12468-12478 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp805226x
 
AbstractFragmentation of protonated RVYIHPF and RVYIHPF-OMe and the corresponding radical cations was studied using time- and collision energy-resolved surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments. Peptide radical cations were produced by gas-phase fragmentation of CoIII(salen)-peptide complexes. Both the energetics and the mechanisms of dissociation of even-electron and odd-electron angiotensin III ions are quite different. Protonated molecules are much more stable toward fragmentation than the corresponding radical cations. RRKM modeling of the experimental data suggests that this stability is largely attributed to differences in threshold energies for dissociation, while activation entropies are very similar. Detailed analysis of the experimental data obtained for radical cations demonstrated the presence of two distinct structures separated by a high free-energy barrier. The two families of structures were ascribed to the canonical and zwitterionic forms of the radical cations produced in our experiments. © 2008 American Chemical Society.
 
ISSN1520-6106
2013 Impact Factor: 3.377
2013 SCImago Journal Rankings: 1.575
 
DOIhttp://dx.doi.org/10.1021/jp805226x
 
ISI Accession Number IDWOS:000259552000040
Funding AgencyGrant Number
Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE
University of Hong Kong
Hong Kong Research Grant Council
Special Administrative Region, China7018/06P
U.S. Department of Energy's Office of Biological and Environmental Research
Funding Information:

This study was partially supported by a grant from the Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE and partially by the University of Hong Kong and Hong Kong Research Grant Council, Special Administrative Region, China (Project No. 7018/06P). The research described in this Article was performed at the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the U.S. Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is operated by Battelle for the U.S. Department of Energy. I.K.C. and C.L. acknowledge participation in the PNNL Interfacial and Condensed Phase Summer Research Institute. We thank Mr. Tao Song (University of Hong Kong) for stimulating discussions.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, Z
 
dc.contributor.authorLam, C
 
dc.contributor.authorChu, IK
 
dc.contributor.authorLaskin, J
 
dc.date.accessioned2010-05-31T03:29:52Z
 
dc.date.available2010-05-31T03:29:52Z
 
dc.date.issued2008
 
dc.description.abstractFragmentation of protonated RVYIHPF and RVYIHPF-OMe and the corresponding radical cations was studied using time- and collision energy-resolved surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments. Peptide radical cations were produced by gas-phase fragmentation of CoIII(salen)-peptide complexes. Both the energetics and the mechanisms of dissociation of even-electron and odd-electron angiotensin III ions are quite different. Protonated molecules are much more stable toward fragmentation than the corresponding radical cations. RRKM modeling of the experimental data suggests that this stability is largely attributed to differences in threshold energies for dissociation, while activation entropies are very similar. Detailed analysis of the experimental data obtained for radical cations demonstrated the presence of two distinct structures separated by a high free-energy barrier. The two families of structures were ascribed to the canonical and zwitterionic forms of the radical cations produced in our experiments. © 2008 American Chemical Society.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Physical Chemistry B, 2008, v. 112 n. 39, p. 12468-12478 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp805226x
 
dc.identifier.doihttp://dx.doi.org/10.1021/jp805226x
 
dc.identifier.epage12478
 
dc.identifier.hkuros155640
 
dc.identifier.isiWOS:000259552000040
Funding AgencyGrant Number
Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE
University of Hong Kong
Hong Kong Research Grant Council
Special Administrative Region, China7018/06P
U.S. Department of Energy's Office of Biological and Environmental Research
Funding Information:

This study was partially supported by a grant from the Chemical Sciences Division, Office of Basic Energy Sciences of the U.S. DOE and partially by the University of Hong Kong and Hong Kong Research Grant Council, Special Administrative Region, China (Project No. 7018/06P). The research described in this Article was performed at the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the U.S. Department of Energy's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is operated by Battelle for the U.S. Department of Energy. I.K.C. and C.L. acknowledge participation in the PNNL Interfacial and Condensed Phase Summer Research Institute. We thank Mr. Tao Song (University of Hong Kong) for stimulating discussions.

 
dc.identifier.issn1520-6106
2013 Impact Factor: 3.377
2013 SCImago Journal Rankings: 1.575
 
dc.identifier.issue39
 
dc.identifier.pmid18781717
 
dc.identifier.scopuseid_2-s2.0-54249102284
 
dc.identifier.spage12468
 
dc.identifier.urihttp://hdl.handle.net/10722/58413
 
dc.identifier.volume112
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jpcbfk
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Physical Chemistry B
 
dc.relation.referencesReferences in Scopus
 
dc.titleThe effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yang, Z</contributor.author>
<contributor.author>Lam, C</contributor.author>
<contributor.author>Chu, IK</contributor.author>
<contributor.author>Laskin, J</contributor.author>
<date.accessioned>2010-05-31T03:29:52Z</date.accessioned>
<date.available>2010-05-31T03:29:52Z</date.available>
<date.issued>2008</date.issued>
<identifier.citation>Journal Of Physical Chemistry B, 2008, v. 112 n. 39, p. 12468-12478</identifier.citation>
<identifier.issn>1520-6106</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/58413</identifier.uri>
<description.abstract>Fragmentation of protonated RVYIHPF and RVYIHPF-OMe and the corresponding radical cations was studied using time- and collision energy-resolved surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments. Peptide radical cations were produced by gas-phase fragmentation of CoIII(salen)-peptide complexes. Both the energetics and the mechanisms of dissociation of even-electron and odd-electron angiotensin III ions are quite different. Protonated molecules are much more stable toward fragmentation than the corresponding radical cations. RRKM modeling of the experimental data suggests that this stability is largely attributed to differences in threshold energies for dissociation, while activation entropies are very similar. Detailed analysis of the experimental data obtained for radical cations demonstrated the presence of two distinct structures separated by a high free-energy barrier. The two families of structures were ascribed to the canonical and zwitterionic forms of the radical cations produced in our experiments. &#169; 2008 American Chemical Society.</description.abstract>
<language>eng</language>
<publisher>American Chemical Society. The Journal&apos;s web site is located at http://pubs.acs.org/journal/jpcbfk</publisher>
<relation.ispartof>Journal of Physical Chemistry B</relation.ispartof>
<title>The effect of the secondary structure on dissociation of peptide radical cations: Fragmentation of angiotensin III and its analogues</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1021/jp805226x</identifier.doi>
<identifier.pmid>18781717</identifier.pmid>
<identifier.scopus>eid_2-s2.0-54249102284</identifier.scopus>
<identifier.hkuros>155640</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-54249102284&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>112</identifier.volume>
<identifier.issue>39</identifier.issue>
<identifier.spage>12468</identifier.spage>
<identifier.epage>12478</identifier.epage>
<identifier.isi>WOS:000259552000040</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Pacific Northwest National Laboratory