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Article: AAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer

TitleAAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer
Authors
Issue Date2008
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://mct.aacrjournals.org/
Citation
Molecular Cancer Therapeutics, 2008, v. 7 n. 9, p. 2855-2865 How to Cite?
AbstractThis study tried to evaluate the application of a novel cancer gene therapy using recombinant adeno-associated virus (AAV) carrying the kringle 1 domain of human hepatocyte growth factor (AAV-HGFK1) in combination with recombinant adenovirus carrying p53 gene (Ad-p53). BALB/c and nude mice models of colon cancer were established and the mice were treated with AAV-HGFK1 alone or in combination with Ad-p53. Combination of AAV-HGFK1 and Ad-p53 significantly prolonged the survival of the mice and also significantly inhibited primary and secondary tumor growth. Histochemical examination of the tumors revealed that AAV-HGFK1+Ad-p53 combinatorial treatment not only induced necrosis and apoptosis in the tumors but also suppressed tumor angiogenesis. The antiangiogenesis effect could likely be attributed to the ability of AAV-HGFK1+Ad-p53 viral cocktail to inhibit endothelial cell migration and proliferation. AAV-HGFK1+Ad-p53 also inhibited tumor cell growth in vitro by inhibiting epidermal growth factor receptor phosphorylation. Therefore, AAV-HGFK1+Ad-p53 cocktail therapy has a significantly higher therapeutic effect than AAV-HGFK1 or Ad-p53 alone and is a novel promising gene therapy for colon cancer. Copyright © 2008 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/58386
ISSN
2015 Impact Factor: 5.579
2015 SCImago Journal Rankings: 3.224
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region, ChinaITS/084/03
RGC HKU7705/07M
Funding Information:

Innovation and Technology Commission of the Hong Kong Special Administrative Region, China, ITS/084/03 (M.C.M. Lin) and RGC HKU7705/07M (M.C.M. Lin).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorNie, Ben_HK
dc.contributor.authorShen, Zen_HK
dc.contributor.authorWen, JBen_HK
dc.contributor.authorWong, OGWen_HK
dc.contributor.authorHsueh, WDen_HK
dc.contributor.authorHuo, LFen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorJiang, Ben_HK
dc.contributor.authorLin, MCMen_HK
dc.date.accessioned2010-05-31T03:29:23Z-
dc.date.available2010-05-31T03:29:23Z-
dc.date.issued2008en_HK
dc.identifier.citationMolecular Cancer Therapeutics, 2008, v. 7 n. 9, p. 2855-2865en_HK
dc.identifier.issn1535-7163en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58386-
dc.description.abstractThis study tried to evaluate the application of a novel cancer gene therapy using recombinant adeno-associated virus (AAV) carrying the kringle 1 domain of human hepatocyte growth factor (AAV-HGFK1) in combination with recombinant adenovirus carrying p53 gene (Ad-p53). BALB/c and nude mice models of colon cancer were established and the mice were treated with AAV-HGFK1 alone or in combination with Ad-p53. Combination of AAV-HGFK1 and Ad-p53 significantly prolonged the survival of the mice and also significantly inhibited primary and secondary tumor growth. Histochemical examination of the tumors revealed that AAV-HGFK1+Ad-p53 combinatorial treatment not only induced necrosis and apoptosis in the tumors but also suppressed tumor angiogenesis. The antiangiogenesis effect could likely be attributed to the ability of AAV-HGFK1+Ad-p53 viral cocktail to inhibit endothelial cell migration and proliferation. AAV-HGFK1+Ad-p53 also inhibited tumor cell growth in vitro by inhibiting epidermal growth factor receptor phosphorylation. Therefore, AAV-HGFK1+Ad-p53 cocktail therapy has a significantly higher therapeutic effect than AAV-HGFK1 or Ad-p53 alone and is a novel promising gene therapy for colon cancer. Copyright © 2008 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://mct.aacrjournals.org/en_HK
dc.relation.ispartofMolecular Cancer Therapeuticsen_HK
dc.titleAAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-7163&volume=7&spage=2855&epage=2865&date=2008&atitle=AAV-HGFK1+and+Ad-p53+Cocktail+Therapy+Prolongs+Survival+of+Mice+with+Colon+Canceren_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/1535-7163.MCT-08-0366en_HK
dc.identifier.pmid18790766en_HK
dc.identifier.scopuseid_2-s2.0-54049136956en_HK
dc.identifier.hkuros151301en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54049136956&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2855en_HK
dc.identifier.epage2865en_HK
dc.identifier.isiWOS:000259387300027-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectDevelopment of Novel AAV based anti-angiogenesis gene therapy for the treatment of liver cancer-
dc.identifier.scopusauthoridNie, B=36103082600en_HK
dc.identifier.scopusauthoridShen, Z=35759640300en_HK
dc.identifier.scopusauthoridWen, JB=36853898300en_HK
dc.identifier.scopusauthoridWong, OGW=7004813981en_HK
dc.identifier.scopusauthoridHsueh, WD=40161565600en_HK
dc.identifier.scopusauthoridHuo, LF=9275343500en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridJiang, B=34770534200en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK

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