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Article: Nucleic acid delivery with chitosan and its derivatives

TitleNucleic acid delivery with chitosan and its derivatives
Authors
KeywordsChitosan
Delivery
Non-viral vectors
Nucleic acid
Transfection efficiency
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jconrel
Citation
Journal Of Controlled Release, 2009, v. 134 n. 3, p. 158-168 How to Cite?
AbstractChitosan is a naturally occurring cationic mucopolysaccharide. It is generally biocompatible, biodegradable, mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able to condense nucleic acids (NA) (both DNA and RNA) and protect them from nuclease degradation, its poor water solubility and low transfection efficacy have impeded its use as an NA carrier. In order to overcome such limitations, a multitude of strategies for chitosan modification and formulation have been proposed. In this article, we will first give a brief overview of the physical and biological properties of chitosan. Then, with a special focus on plasmid DNA delivery, we will have a detailed discussion of the latest advances in chitosan-mediated NA transfer. For future research, the following three important areas will be discussed: chitosan-mediated therapeutic small RNA transfer, structure-activity relationships (SAR) in chitosan vector design, and chitosan-mediated oral/nasal NA therapy. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58360
ISSN
2015 Impact Factor: 7.441
2015 SCImago Journal Rankings: 2.827
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, WFen_HK
dc.contributor.authorLin, MCMen_HK
dc.date.accessioned2010-05-31T03:28:57Z-
dc.date.available2010-05-31T03:28:57Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Controlled Release, 2009, v. 134 n. 3, p. 158-168en_HK
dc.identifier.issn0168-3659en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58360-
dc.description.abstractChitosan is a naturally occurring cationic mucopolysaccharide. It is generally biocompatible, biodegradable, mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able to condense nucleic acids (NA) (both DNA and RNA) and protect them from nuclease degradation, its poor water solubility and low transfection efficacy have impeded its use as an NA carrier. In order to overcome such limitations, a multitude of strategies for chitosan modification and formulation have been proposed. In this article, we will first give a brief overview of the physical and biological properties of chitosan. Then, with a special focus on plasmid DNA delivery, we will have a detailed discussion of the latest advances in chitosan-mediated NA transfer. For future research, the following three important areas will be discussed: chitosan-mediated therapeutic small RNA transfer, structure-activity relationships (SAR) in chitosan vector design, and chitosan-mediated oral/nasal NA therapy. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jconrelen_HK
dc.relation.ispartofJournal of Controlled Releaseen_HK
dc.rightsJournal of controlled release. Copyright © Elsevier BV.en_HK
dc.subjectChitosanen_HK
dc.subjectDeliveryen_HK
dc.subjectNon-viral vectorsen_HK
dc.subjectNucleic aciden_HK
dc.subjectTransfection efficiencyen_HK
dc.titleNucleic acid delivery with chitosan and its derivativesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-3659&volume=134&issue=3&spage=158&epage=168&date=2008&atitle=Nucleic+Acid+Delivery+with+Chitosan+and+its+Derivativesen_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jconrel.2008.11.021en_HK
dc.identifier.pmid19100795-
dc.identifier.scopuseid_2-s2.0-61349123258en_HK
dc.identifier.hkuros154155en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61349123258&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume134en_HK
dc.identifier.issue3en_HK
dc.identifier.spage158en_HK
dc.identifier.epage168en_HK
dc.identifier.isiWOS:000264722000002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLai, WF=35603486100en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.citeulike6457000-

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