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Article: Identification and characterization of metallodrug binding proteins by (metallo)proteomics

TitleIdentification and characterization of metallodrug binding proteins by (metallo)proteomics
Authors
Issue Date2009
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/MT/About.asp
Citation
Metallomics, 2009, v. 1 n. 1, p. 25-31 How to Cite?
AbstractThe success of cisplatin in clinic has stimulated great interest in the development and application of metal-based drugs for therapeutic and diagnostic purposes. However, the treatment efficiency of metallodrugs suffers from side-effects and drug resistance. To overcome these challenges, targets of these metal-based drugs should be identified in order to understand the molecular mechanisms of actions of these compounds and to the intrinsic or acquired drug resistance by cancer cells and infectious microbes. This review summaries some of the recent developments in the identification of binding proteins and their target sites of platinum-, ruthenium-, gold-, arsenic- and bismuth-containing agents by proteomics and metalloproteomics, which may provide a rational basis for the design of new metal-based drugs.
Persistent Identifierhttp://hdl.handle.net/10722/58322
ISSN
2015 Impact Factor: 3.54
2015 SCImago Journal Rankings: 1.120
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU7039/04P
HKU7043/06P
HKU7042/07P
HKU1/07C
Area of Excellence Scheme of the University Grants Committee
Institute of molecular technology for drug discovery and synthesisAoE/P-10/01
University of Hong Kong
Funding Information:

This work was supported by the Research Grants Council of Hong Kong (HKU7039/04P, HKU7043/06P, HKU7042/07P, HKU1/07C), the Area of Excellence Scheme of the University Grants Committee, Institute of molecular technology for drug discovery and synthesis (AoE/P-10/01) and The University of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSun, Xen_HK
dc.contributor.authorTsang, CNen_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2010-05-31T03:28:16Z-
dc.date.available2010-05-31T03:28:16Z-
dc.date.issued2009en_HK
dc.identifier.citationMetallomics, 2009, v. 1 n. 1, p. 25-31en_HK
dc.identifier.issn1756-5901en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58322-
dc.description.abstractThe success of cisplatin in clinic has stimulated great interest in the development and application of metal-based drugs for therapeutic and diagnostic purposes. However, the treatment efficiency of metallodrugs suffers from side-effects and drug resistance. To overcome these challenges, targets of these metal-based drugs should be identified in order to understand the molecular mechanisms of actions of these compounds and to the intrinsic or acquired drug resistance by cancer cells and infectious microbes. This review summaries some of the recent developments in the identification of binding proteins and their target sites of platinum-, ruthenium-, gold-, arsenic- and bismuth-containing agents by proteomics and metalloproteomics, which may provide a rational basis for the design of new metal-based drugs.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/MT/About.aspen_HK
dc.relation.ispartofMetallomicsen_HK
dc.titleIdentification and characterization of metallodrug binding proteins by (metallo)proteomicsen_HK
dc.typeArticleen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b813121jen_HK
dc.identifier.scopuseid_2-s2.0-75749091808en_HK
dc.identifier.hkuros154626en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75749091808&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage31en_HK
dc.identifier.isiWOS:000268924300002-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridSun, X=35799316500en_HK
dc.identifier.scopusauthoridTsang, CN=36624389600en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK

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