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Article: The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands

TitleThe anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands
Authors
KeywordsApoptosis
Cancer
Cytotoxicity
Gold
Porphyrin
Tetradentate ligands
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccr
Citation
Coordination Chemistry Reviews, 2009, v. 253 n. 11-12, p. 1682-1691 How to Cite?
AbstractGold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. A reduction of gold(III) to gold(I) is usually the case for most cytotoxic gold(III) compounds. Previously, we made use of planar tetradentate dianionic ligands, including porphyrin, Schiff base and bis(pyridyl)carboxamide ligands, to prepare a series of monocationic gold(III) compounds. These gold(III) compounds behave as organic lipophilic cations with a planar structure, are stable under physiological conditions, and possess certain promising anti-cancer activities. In this review, the synthesis, stability, and anti-cancer properties of these gold(III) compounds are presented. We shall detail the in vitro and in vivo anti-cancer efficacy, as well as the anti-cancer mechanisms of the most potent gold(III) porphyrin compound [AuIII(TPP)]Cl (1a). © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58319
ISSN
2015 Impact Factor: 12.994
2015 SCImago Journal Rankings: 4.100
ISI Accession Number ID
Funding AgencyGrant Number
University Development Fund of The University of Hong Kong, the Hong Kong Research
Funding Information:

We acknowledge support from the University Development Fund of The University of Hong Kong, the Hong Kong Research Grants Council, and the University Grants Committee of the Hong Kong SAR of China (Areas of Excellence Scheme, AoE/P-10/01). We thank Dr. C.-N. Lok for his helpful discussion. Pacific Edit reviewed the manuscript prior to submission.

References

 

DC FieldValueLanguage
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-05-31T03:28:13Z-
dc.date.available2010-05-31T03:28:13Z-
dc.date.issued2009en_HK
dc.identifier.citationCoordination Chemistry Reviews, 2009, v. 253 n. 11-12, p. 1682-1691en_HK
dc.identifier.issn0010-8545en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58319-
dc.description.abstractGold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. A reduction of gold(III) to gold(I) is usually the case for most cytotoxic gold(III) compounds. Previously, we made use of planar tetradentate dianionic ligands, including porphyrin, Schiff base and bis(pyridyl)carboxamide ligands, to prepare a series of monocationic gold(III) compounds. These gold(III) compounds behave as organic lipophilic cations with a planar structure, are stable under physiological conditions, and possess certain promising anti-cancer activities. In this review, the synthesis, stability, and anti-cancer properties of these gold(III) compounds are presented. We shall detail the in vitro and in vivo anti-cancer efficacy, as well as the anti-cancer mechanisms of the most potent gold(III) porphyrin compound [AuIII(TPP)]Cl (1a). © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccren_HK
dc.relation.ispartofCoordination Chemistry Reviewsen_HK
dc.rightsCoordination Chemistry Reviews. Copyright © Elsevier BV.en_HK
dc.subjectApoptosisen_HK
dc.subjectCanceren_HK
dc.subjectCytotoxicityen_HK
dc.subjectGolden_HK
dc.subjectPorphyrinen_HK
dc.subjectTetradentate ligandsen_HK
dc.titleThe anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligandsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-8545&volume=253&spage=1682&epage=1691&date=2009&atitle=The+anti-cancer+properties+of+gold(III)+compounds+with+dianionic+porphyrin+and+tetradentate+ligandsen_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ccr.2009.02.017en_HK
dc.identifier.scopuseid_2-s2.0-64049113556en_HK
dc.identifier.hkuros156400en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64049113556&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume253en_HK
dc.identifier.issue11-12en_HK
dc.identifier.spage1682en_HK
dc.identifier.epage1691en_HK
dc.identifier.isiWOS:000266188500009-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.citeulike5231879-

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