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Article: Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA

TitlePlatinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2009, v. 131 n. 5, p. 1835-1846 How to Cite?
AbstractA series of platinum(ll) complexes containing dipyridophenazine (dppz) and C-deprotonated 2-phenylpyridine (N^CH) ligands were prepared and assayed for G-quadruplex DNA binding activities. [Pt"(dppz-COOH)(N^C)]CF 3S03 (1; dppz-COOH = 11-carboxydipyrido[3,2-a:2,3-c] phenazine) binds G-quadruplex DNA through an external end-stacking mode with a binding affinity of ̃107 dm3 mol-1. G-quadruplex DNA binding is accompanied by up to a 293-fold increase in the intensity of photoluminescence at λmax = 512 nm. Using a biotinylated-primer extension telomerase assay, 1 was shown to be an effective inhibitor of human telomerase in vitro, with a telIC50 value of 760 nM. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/58314
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
References

 

DC FieldValueLanguage
dc.contributor.authorDikLung, Men_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorYan, SCen_HK
dc.date.accessioned2010-05-31T03:28:08Z-
dc.date.available2010-05-31T03:28:08Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2009, v. 131 n. 5, p. 1835-1846en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58314-
dc.description.abstractA series of platinum(ll) complexes containing dipyridophenazine (dppz) and C-deprotonated 2-phenylpyridine (N^CH) ligands were prepared and assayed for G-quadruplex DNA binding activities. [Pt"(dppz-COOH)(N^C)]CF 3S03 (1; dppz-COOH = 11-carboxydipyrido[3,2-a:2,3-c] phenazine) binds G-quadruplex DNA through an external end-stacking mode with a binding affinity of ̃107 dm3 mol-1. G-quadruplex DNA binding is accompanied by up to a 293-fold increase in the intensity of photoluminescence at λmax = 512 nm. Using a biotinylated-primer extension telomerase assay, 1 was shown to be an effective inhibitor of human telomerase in vitro, with a telIC50 value of 760 nM. © 2009 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.titlePlatinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNAen_HK
dc.typeArticleen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja806045x-
dc.identifier.scopuseid_2-s2.0-67849111941en_HK
dc.identifier.hkuros155988en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67849111941&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume131en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1835en_HK
dc.identifier.epage1846en_HK
dc.identifier.eissn1520-5126-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDikLung, M=23392107800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridYan, SC=7401744858en_HK

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