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Article: Coexpression of GABA BR1 and GABA BR2 receptor subunits in the rat vestibular nucleus

TitleCoexpression of GABA BR1 and GABA BR2 receptor subunits in the rat vestibular nucleus
Authors
KeywordsCoexpression
GABA B receptors
Immunohistochemistry
Vestibular nucleus
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/nba
Citation
Neuroembryology and Aging, 2008, v. 5 n. 4, p. 127-133 How to Cite?
AbstractThe expression patterns of the two subunits of the metabotropic GABA B receptor, GABA BR1 and GABA BR2, vary among various neural regions and their relative expression in the rat central vestibular system remains unknown. To identify the expression patterns of these two subunits of the metabotropic GABA B receptor in the vestibular nucleus of adult rats, double immunofluorescence experiments were performed. GABA BR1 or GABA BR2 immunoreactivity was observed in neurons and neuropilar elements of the vestibular nuclear complex and its subgroups x and y. These neurons were oval, multipolar, fusiform or triangular in shape. In contrast to other brain regions, individual neurons or neuropil within the various vestibular subnuclei and subgroups displayed comparable levels of GABA BR1 and GABA BR2 immunoreactivity. Double immunofluorescence experiments further demonstrated the coexpression of GABA BR1 and GABA BR2 receptor subunits in individual central vestibular neurons. The present findings provide histological evidence of the heterodimeric nature of GABA B receptors that mediate inhibitory neurotransmission in the rat vestibular nuclei. Copyright © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/58298
ISSN
2011 SCImago Journal Rankings: 0.130
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CHen_HK
dc.contributor.authorNg, KYen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-05-31T03:27:40Z-
dc.date.available2010-05-31T03:27:40Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroembryology and Aging, 2008, v. 5 n. 4, p. 127-133en_HK
dc.identifier.issn1661-3406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58298-
dc.description.abstractThe expression patterns of the two subunits of the metabotropic GABA B receptor, GABA BR1 and GABA BR2, vary among various neural regions and their relative expression in the rat central vestibular system remains unknown. To identify the expression patterns of these two subunits of the metabotropic GABA B receptor in the vestibular nucleus of adult rats, double immunofluorescence experiments were performed. GABA BR1 or GABA BR2 immunoreactivity was observed in neurons and neuropilar elements of the vestibular nuclear complex and its subgroups x and y. These neurons were oval, multipolar, fusiform or triangular in shape. In contrast to other brain regions, individual neurons or neuropil within the various vestibular subnuclei and subgroups displayed comparable levels of GABA BR1 and GABA BR2 immunoreactivity. Double immunofluorescence experiments further demonstrated the coexpression of GABA BR1 and GABA BR2 receptor subunits in individual central vestibular neurons. The present findings provide histological evidence of the heterodimeric nature of GABA B receptors that mediate inhibitory neurotransmission in the rat vestibular nuclei. Copyright © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/nbaen_HK
dc.relation.ispartofNeuroembryology and Agingen_HK
dc.rightsNeuroembryology and Aging . Copyright © S Karger AG.en_HK
dc.subjectCoexpressionen_HK
dc.subjectGABA B receptorsen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectVestibular nucleusen_HK
dc.titleCoexpression of GABA BR1 and GABA BR2 receptor subunits in the rat vestibular nucleusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1661-3406&volume=5&spage=127&epage=133&date=2008&atitle=Coexpression+of+GABABR1+and+GABABR2+Receptor+Subunits+in+the+Rat+Vestibular+Nucleusen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000193850en_HK
dc.identifier.scopuseid_2-s2.0-77949411748en_HK
dc.identifier.hkuros158360en_HK
dc.identifier.hkuros164159-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949411748&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue4en_HK
dc.identifier.spage127en_HK
dc.identifier.epage133en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridNg, KY=55244359500en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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