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Article: Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration

TitleDevelopmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration
Authors
Keywordsc-fos
Glutamate receptor
Gravity
Postnatal
Issue Date2008
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation
European Journal Of Neuroscience, 2008, v. 28 n. 11, p. 2157-2172 How to Cite?
AbstractWe investigated the maturation profile of subunits of ionotropic glutamate receptors in vestibular nuclear neurons that were activated by sinusoidal linear acceleration along the vertical plane. The otolithic origin of Fos expression in these neurons was confirmed as a marker of functional activation when labyrinthectomized and/or stationary control rats contrasted by showing sporadically scattered Fos-labeled neurons in the vestibular nuclei. By double immunohistochemistry for Fos and one of the receptor subunits, otolith-related neurons that expressed either α-amino-3-hydroxy-5-methyl-4-isoxazole- propionate or N-methyl-d-aspartate subunits were first identified in the medial vestibular nucleus, spinal vestibular nucleus and Group x by postnatal day (P)7, and in the lateral vestibular nucleus and Group y by P9. No double-labeled neurons were found in the superior vestibular nucleus. Within each vestibular subnucleus, these double-labeled neurons constituted ∼90% of the total Fos-labeled neurons. The percentage of Fos-labeled neurons expressing the GluR1 or NR2A subunit showed developmental invariance in all subnuclei. For Fos-labeled neurons expressing the NR1 subunit, similar invariance was observed except that, in Group y, these neurons decreased from P14 onwards. For Fos-labeled neurons expressing the GluR2, GluR2/3, GluR4 or NR2B subunit, a significant decrease was found by the adult stage. In particular, those expressing the GluR4 subunit showed a two- to threefold decrease in the medial vestibular nucleus, spinal vestibular nucleus and Group y. Also, those expressing the NR2B subunit showed a twofold decrease in Group y. Taken together, the postsynaptic expression of ionotropic glutamate receptor subunits in different vestibular subnuclei suggests that glutamatergic transmission within subregions plays differential developmental roles in the coding of gravity-related vertical spatial information. © The Authors (2008).
Persistent Identifierhttp://hdl.handle.net/10722/58293
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 2.130
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7370/04M
7485/05M
Funding Information:

The authors are grateful to Mr Simon S. M. Chan and Miss Kimmy F. L. Tsang for their excellent technical assistance. This work was supported by grants from the Hong Kong Research Grants Council ( HKU7370/04M and 7485/05M).

References

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-05-31T03:27:35Z-
dc.date.available2010-05-31T03:27:35Z-
dc.date.issued2008en_HK
dc.identifier.citationEuropean Journal Of Neuroscience, 2008, v. 28 n. 11, p. 2157-2172en_HK
dc.identifier.issn0953-816Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/58293-
dc.description.abstractWe investigated the maturation profile of subunits of ionotropic glutamate receptors in vestibular nuclear neurons that were activated by sinusoidal linear acceleration along the vertical plane. The otolithic origin of Fos expression in these neurons was confirmed as a marker of functional activation when labyrinthectomized and/or stationary control rats contrasted by showing sporadically scattered Fos-labeled neurons in the vestibular nuclei. By double immunohistochemistry for Fos and one of the receptor subunits, otolith-related neurons that expressed either α-amino-3-hydroxy-5-methyl-4-isoxazole- propionate or N-methyl-d-aspartate subunits were first identified in the medial vestibular nucleus, spinal vestibular nucleus and Group x by postnatal day (P)7, and in the lateral vestibular nucleus and Group y by P9. No double-labeled neurons were found in the superior vestibular nucleus. Within each vestibular subnucleus, these double-labeled neurons constituted ∼90% of the total Fos-labeled neurons. The percentage of Fos-labeled neurons expressing the GluR1 or NR2A subunit showed developmental invariance in all subnuclei. For Fos-labeled neurons expressing the NR1 subunit, similar invariance was observed except that, in Group y, these neurons decreased from P14 onwards. For Fos-labeled neurons expressing the GluR2, GluR2/3, GluR4 or NR2B subunit, a significant decrease was found by the adult stage. In particular, those expressing the GluR4 subunit showed a two- to threefold decrease in the medial vestibular nucleus, spinal vestibular nucleus and Group y. Also, those expressing the NR2B subunit showed a twofold decrease in Group y. Taken together, the postsynaptic expression of ionotropic glutamate receptor subunits in different vestibular subnuclei suggests that glutamatergic transmission within subregions plays differential developmental roles in the coding of gravity-related vertical spatial information. © The Authors (2008).en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJNen_HK
dc.relation.ispartofEuropean Journal of Neuroscienceen_HK
dc.rightsEuropean Journal of Neuroscience. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectc-fosen_HK
dc.subjectGlutamate receptoren_HK
dc.subjectGravityen_HK
dc.subjectPostnatalen_HK
dc.subject.meshAccelerationen_HK
dc.subject.meshAging - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBiological Markers - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGravity Sensing - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeurons - metabolismen_HK
dc.subject.meshOtolithic Membrane - physiologyen_HK
dc.subject.meshPostural Balance - physiologyen_HK
dc.subject.meshProtein Subunits - metabolismen_HK
dc.subject.meshProto-Oncogene Proteins c-fos - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptors, AMPA - metabolismen_HK
dc.subject.meshReceptors, N-Methyl-D-Aspartate - metabolismen_HK
dc.subject.meshVestibular Nuclei - growth & developmenten_HK
dc.titleDevelopmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear accelerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0953-816X&volume=11&spage=2157&epage=2172&date=2008&atitle=Developmental+maturation+of+ionotropic+glutamate+receptor+subunits+in+rat+vestibular+nuclear+neurons+responsive+to+vertical+linear+accelerationen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1460-9568.2008.06523.xen_HK
dc.identifier.pmid19046363-
dc.identifier.scopuseid_2-s2.0-56749152461en_HK
dc.identifier.hkuros158322en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56749152461&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2157en_HK
dc.identifier.epage2172en_HK
dc.identifier.isiWOS:000261184800001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridTse, YC=7005116869en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.citeulike3722691-

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