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Article: Molecular and cellular aspects of plasticity after neural injury

TitleMolecular and cellular aspects of plasticity after neural injury
Authors
Issue Date2008
PublisherBentham Open. The Journal's web site is located at http://www.bentham.org/open/jms/
Citation
Journal of Medical Sciences, 2008, v. 1 n. 2, p. 73-79 How to Cite?
AbstractThis review focuses on our effort to address plasticity of the nervous system after neural injury. We have used different animal models to examine cellular mechanisms of plasticity underlying the pathological and repair processes. After severance of sensory input from one inner ear, topographic representations of spacecentered coordinates in the brain undergo plastic changes. During vestibular compensation, tissue plasticity constitutes an important component for functional recovery of neuronal network. In Parkinsonian animals, modulation of signaling via glutamatergic synapses, neurotrophins and neurokinins contributes to the protection of basal ganglion neurons from degeneration, thereby delaying deterioration of motor functions. With the use of animal models of neural injury, we further overcome the molecular restriction at the glial scar to enhance neural regrowth and remyelination, pointing to the possibility of developing new therapeutic strategies to stimulate neural plasticity and repair in the adult nervous system.
Persistent Identifierhttp://hdl.handle.net/10722/58284
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_HK
dc.contributor.authorChen, LWen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.date.accessioned2010-05-31T03:27:25Z-
dc.date.available2010-05-31T03:27:25Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal of Medical Sciences, 2008, v. 1 n. 2, p. 73-79en_HK
dc.identifier.issn1996-3262-
dc.identifier.urihttp://hdl.handle.net/10722/58284-
dc.description.abstractThis review focuses on our effort to address plasticity of the nervous system after neural injury. We have used different animal models to examine cellular mechanisms of plasticity underlying the pathological and repair processes. After severance of sensory input from one inner ear, topographic representations of spacecentered coordinates in the brain undergo plastic changes. During vestibular compensation, tissue plasticity constitutes an important component for functional recovery of neuronal network. In Parkinsonian animals, modulation of signaling via glutamatergic synapses, neurotrophins and neurokinins contributes to the protection of basal ganglion neurons from degeneration, thereby delaying deterioration of motor functions. With the use of animal models of neural injury, we further overcome the molecular restriction at the glial scar to enhance neural regrowth and remyelination, pointing to the possibility of developing new therapeutic strategies to stimulate neural plasticity and repair in the adult nervous system.-
dc.languageengen_HK
dc.publisherBentham Open. The Journal's web site is located at http://www.bentham.org/open/jms/-
dc.relation.ispartofJournal of Medical Sciencesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMolecular and cellular aspects of plasticity after neural injuryen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2174/1996327000801020033-
dc.identifier.hkuros149924en_HK
dc.identifier.volume1-
dc.identifier.issue2-
dc.identifier.spage73-
dc.identifier.epage79-
dc.publisher.placeNetherlands-

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