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Article: A study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chinese

TitleA study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chinese
Authors
KeywordsAlzheimer's disease
Case-control study
Chromosome 12
Genetics
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DEM
Citation
Dementia And Geriatric Cognitive Disorders, 2009, v. 27 n. 6, p. 508-512 How to Cite?
AbstractRecent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese. © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/58272
ISSN
2015 Impact Factor: 3.408
2015 SCImago Journal Rankings: 1.194
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorYik, PYen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2010-05-31T03:27:12Z-
dc.date.available2010-05-31T03:27:12Z-
dc.date.issued2009en_HK
dc.identifier.citationDementia And Geriatric Cognitive Disorders, 2009, v. 27 n. 6, p. 508-512en_HK
dc.identifier.issn1420-8008en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58272-
dc.description.abstractRecent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese. © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DEMen_HK
dc.relation.ispartofDementia and Geriatric Cognitive Disordersen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsDementia and Geriatric Cognitive Disorders. Copyright © S Karger AG.-
dc.subjectAlzheimer's diseaseen_HK
dc.subjectCase-control studyen_HK
dc.subjectChromosome 12en_HK
dc.subjectGeneticsen_HK
dc.subject.meshAlleles-
dc.subject.meshAlzheimer Disease - epidemiology - genetics-
dc.subject.meshChromosomes, Human, Pair 12 - genetics-
dc.subject.meshHaplotypes-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleA study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1420-8008&volume=27&issue=6&spage=508&epage=512&date=2009&atitle=A+study+on+the+association+of+the+chromosome+12p13+locus+with+sporadic+late-onset+Alzheimer%27s+disease+in+Chinese-
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1159/000218740en_HK
dc.identifier.pmid19451718-
dc.identifier.scopuseid_2-s2.0-65649100541en_HK
dc.identifier.hkuros167554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65649100541&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage508en_HK
dc.identifier.epage512en_HK
dc.identifier.isiWOS:000269160500003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLi, Y=36078824800en_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridLi, Z=26642887400en_HK
dc.identifier.scopusauthoridYik, PY=15060623700en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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