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Article: A study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chinese

TitleA study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chinese
Authors
Li, YChu, LWLi, ZYik, PYSong, YQ
KeywordsAlzheimer's disease
Case-control study
Chromosome 12
Genetics
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DEM
Citation
Dementia And Geriatric Cognitive Disorders, 2009, v. 27 n. 6, p. 508-512 How to Cite?
DOI: http://dx.doi.org/10.1159/000218740
AbstractRecent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese. © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/58272
ISSN
1420-8008
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.809
ISI Accession Number ID
WOS:000269160500003
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorYik, PYen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2010-05-31T03:27:12Z-
dc.date.available2010-05-31T03:27:12Z-
dc.date.issued2009en_HK
dc.identifier.citationDementia And Geriatric Cognitive Disorders, 2009, v. 27 n. 6, p. 508-512en_HK
dc.identifier.issn1420-8008en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58272-
dc.description.abstractRecent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese. © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DEMen_HK
dc.relation.ispartofDementia and Geriatric Cognitive Disordersen_HK
dc.rightsDementia and Geriatric Cognitive Disorders. Copyright © S Karger AG.-
dc.subjectAlzheimer's diseaseen_HK
dc.subjectCase-control studyen_HK
dc.subjectChromosome 12en_HK
dc.subjectGeneticsen_HK
dc.subject.meshAlleles-
dc.subject.meshAlzheimer Disease - epidemiology - genetics-
dc.subject.meshChromosomes, Human, Pair 12 - genetics-
dc.subject.meshHaplotypes-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleA study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1420-8008&volume=27&issue=6&spage=508&epage=512&date=2009&atitle=A+study+on+the+association+of+the+chromosome+12p13+locus+with+sporadic+late-onset+Alzheimer%27s+disease+in+Chinese-
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1159/000218740en_HK
dc.identifier.pmid19451718-
dc.identifier.scopuseid_2-s2.0-65649100541en_HK
dc.identifier.hkuros167554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65649100541&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage508en_HK
dc.identifier.epage512en_HK
dc.identifier.isiWOS:000269160500003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLi, Y=36078824800en_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridLi, Z=26642887400en_HK
dc.identifier.scopusauthoridYik, PY=15060623700en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.issnl1420-8008-

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