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Article: Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI

TitleAge-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI
Authors
KeywordsAging
Deuterium oxide
Intervertebral disc
Magnetic resonance imaging
Rabbit
Issue Date2008
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/joca
Citation
Osteoarthritis And Cartilage, 2008, v. 16 n. 11, p. 1312-1318 How to Cite?
AbstractObjectives: Intervertebral disc (IVD) degeneration is associated with a loss of disc water content and change in biochemical composition of the disc. Rabbit is a frequently used model to evaluate the efficacy of therapeutics for disc degeneration. This study addresses whether rabbits undergo age-related disc degeneration, assessed using deuterium oxide-assisted magnetic resonance imaging (MRI) of the lumbar IVDs. Materials and methods: The lumbar spines of adolescent, adult, and aged rabbits (6-36 months) were subjected to T2-weighted/short-tau inversion recovery (STIR) MRI scan along with water-deuterium oxide (H2O:D2O) dilutions. The total and maximum H2O:D2O index (HDi) of the lumbar IVDs were determined and compared between disc levels at different ages. Results: Adolescent rabbit lumbar discs had similar total HDi, suggesting the hydration and biochemical composition was similar among the lumbar levels. With the use of H2O:D2O reference, the discs were shown to undergo continual decrease in signal with aging which non-calibrated measurement method could not reveal. The HDi decrease rate was higher at the caudal than cranial levels. Conclusion: This study provided in vivo evidence of age-related progressive disc degenerative change in rabbit lumbar discs, suggesting aged rabbits can be considered as a natural disc degeneration model in disc regeneration studies. However, it is important to select proper disc levels as intra-subject controls due to different rates of degenerative changes between caudal and cranial levels. © 2008 Osteoarthritis Research Society International.
Persistent Identifierhttp://hdl.handle.net/10722/58254
ISSN
2015 Impact Factor: 4.535
2015 SCImago Journal Rankings: 1.901
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region of ChinaHKU7496/05M
Funding Information:

We thank Dr Gladys Lo in Department of Diagnostic Radiology, Hong Kong Sanatorium and Hospital to provide the MRI scan service. The work described in this paper was funded by the University Grants Committee (project no. HKU7496/05M) of the Hong Kong Special Administrative Region of China.

References

 

DC FieldValueLanguage
dc.contributor.authorLeung, VYLen_HK
dc.contributor.authorHung, SCen_HK
dc.contributor.authorLi, LCen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-05-31T03:26:52Z-
dc.date.available2010-05-31T03:26:52Z-
dc.date.issued2008en_HK
dc.identifier.citationOsteoarthritis And Cartilage, 2008, v. 16 n. 11, p. 1312-1318en_HK
dc.identifier.issn1063-4584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58254-
dc.description.abstractObjectives: Intervertebral disc (IVD) degeneration is associated with a loss of disc water content and change in biochemical composition of the disc. Rabbit is a frequently used model to evaluate the efficacy of therapeutics for disc degeneration. This study addresses whether rabbits undergo age-related disc degeneration, assessed using deuterium oxide-assisted magnetic resonance imaging (MRI) of the lumbar IVDs. Materials and methods: The lumbar spines of adolescent, adult, and aged rabbits (6-36 months) were subjected to T2-weighted/short-tau inversion recovery (STIR) MRI scan along with water-deuterium oxide (H2O:D2O) dilutions. The total and maximum H2O:D2O index (HDi) of the lumbar IVDs were determined and compared between disc levels at different ages. Results: Adolescent rabbit lumbar discs had similar total HDi, suggesting the hydration and biochemical composition was similar among the lumbar levels. With the use of H2O:D2O reference, the discs were shown to undergo continual decrease in signal with aging which non-calibrated measurement method could not reveal. The HDi decrease rate was higher at the caudal than cranial levels. Conclusion: This study provided in vivo evidence of age-related progressive disc degenerative change in rabbit lumbar discs, suggesting aged rabbits can be considered as a natural disc degeneration model in disc regeneration studies. However, it is important to select proper disc levels as intra-subject controls due to different rates of degenerative changes between caudal and cranial levels. © 2008 Osteoarthritis Research Society International.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jocaen_HK
dc.relation.ispartofOsteoarthritis and Cartilageen_HK
dc.subjectAgingen_HK
dc.subjectDeuterium oxideen_HK
dc.subjectIntervertebral discen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectRabbiten_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDeuterium Oxide - diagnostic use - metabolismen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshIntervertebral Disc Displacement - physiopathology - radiographyen_HK
dc.subject.meshLumbosacral Region - pathology - radiographyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshRabbitsen_HK
dc.titleAge-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRIen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1063-4584&volume=16 &issue=11&spage=1312&epage=8&date=2008&atitle=Age-related+degeneration+of+lumbar+intervertebral+discs+in+rabbits+revealed+by+deuterium+oxide-assisted+MRIen_HK
dc.identifier.emailLeung, VYL: vicleung@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authorityLeung, VYL=rp01764en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.joca.2008.03.015en_HK
dc.identifier.pmid18440246-
dc.identifier.scopuseid_2-s2.0-53849101396en_HK
dc.identifier.hkuros141212en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53849101396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1312en_HK
dc.identifier.epage1318en_HK
dc.identifier.isiWOS:000261049800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, VYL=35337438900en_HK
dc.identifier.scopusauthoridHung, SC=35757582000en_HK
dc.identifier.scopusauthoridLi, LC=8576363100en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK

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