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Article: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model

TitleModulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model
Authors
KeywordsGlaucoma
Microglia
Neuroprotection
Wolfberry
Issue Date2009
Citation
Journal Of Ocular Biology, Diseases, And Informatics, 2009, v. 2 n. 2, p. 47-56 How to Cite?
AbstractThe active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mounted retinas. Retinas under OH displayed slightly activated microglia. One to 100 mg/kg LBP exerted the best neuroprotection and elicited moderately activated microglia in the inner retina with ramified appearance but thicker and focally enlarged processes. Intravitreous injection of lipopolysaccharide decreased the survival of RGCs at 4 weeks, and the activated microglia exhibited amoeboid appearance as fully activated phenotype. When activation of microglia was attenuated by intravitreous injection of macrophage/microglia inhibitory factor, protective effect of 10 mg/kg LBP was attenuated. The results implicated that neuroprotective effects of LBP were partly due to modulating the activation of microglia. © 2009 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/58243
ISSN
2015 SCImago Journal Rankings: 0.183
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, Ken_HK
dc.contributor.authorChan, HCen_HK
dc.contributor.authorYeung, SCen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorZee, SYen_HK
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-05-31T03:26:29Z-
dc.date.available2010-05-31T03:26:29Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Ocular Biology, Diseases, And Informatics, 2009, v. 2 n. 2, p. 47-56en_HK
dc.identifier.issn1936-8445en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58243-
dc.description.abstractThe active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mounted retinas. Retinas under OH displayed slightly activated microglia. One to 100 mg/kg LBP exerted the best neuroprotection and elicited moderately activated microglia in the inner retina with ramified appearance but thicker and focally enlarged processes. Intravitreous injection of lipopolysaccharide decreased the survival of RGCs at 4 weeks, and the activated microglia exhibited amoeboid appearance as fully activated phenotype. When activation of microglia was attenuated by intravitreous injection of macrophage/microglia inhibitory factor, protective effect of 10 mg/kg LBP was attenuated. The results implicated that neuroprotective effects of LBP were partly due to modulating the activation of microglia. © 2009 The Author(s).en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of Ocular Biology, Diseases, and Informaticsen_HK
dc.subjectGlaucomaen_HK
dc.subjectMicrogliaen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectWolfberryen_HK
dc.titleModulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension modelen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s12177-009-9023-9en_HK
dc.identifier.pmid19672466-
dc.identifier.pmcidPMC2723674-
dc.identifier.scopuseid_2-s2.0-68949201485en_HK
dc.identifier.hkuros163882en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68949201485&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue2en_HK
dc.identifier.spage47en_HK
dc.identifier.epage56en_HK
dc.identifier.scopusauthoridChiu, K=15076970500en_HK
dc.identifier.scopusauthoridChan, HC=16494446300en_HK
dc.identifier.scopusauthoridYeung, SC=25923636600en_HK
dc.identifier.scopusauthoridYuen, WH=7102761282en_HK
dc.identifier.scopusauthoridZee, SY=7004001733en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.citeulike5117037-

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