Article: Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

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TitlePromotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
AuthorsMi, S5
Miller, RH1
Tang, W5
Lee, X5
Hu, B4
Wu, W4
Zhang, Y6
Shields, CB6
Zhang, Y6
Miklasz, S5
Shea, D5
Mason, J2
Franklin, RJM7
Ji, B5
Shao, Z5
Chédotal, A3
Bernard, F3
Roulois, A7
Xu, J5
Jung, V5
Pepinsky, B5
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
CitationAnnals Of Neurology, 2009, v. 65 n. 3, p. 304-315 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ana.21581
AbstractObjective: Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of myelination during repair is poorly understood. In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo. Methods: The effects of LINGO-1 antagonists on the differentiation of OPCs and the promotion of myelination has been assayed using a combination of coculture and slice culture preparations. Using three different animal models of demyelination and remyelination, we morphologically and functionally assessed the effects of LINGO-1 antagonists on OPC differentiation and myelin repair. Results: The data indicate that in vitro treatment with antagonists of LINGO-1 promote OPC differentiation and myelination, whereas in vivo remyelination is accelerated in lysophosphatidylcholine- or cuprizone-induced demyelination. This remyelination is associated with enhanced OPC differentiation and functional recovery of conduction velocities in demyelinated axons. Interpretation: Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination. © 2009 American Neurological Association.
ISSN0364-5134
2011 Impact Factor: 11.089
2011 SCImago Journal Rankings: 1.024
DOIhttp://dx.doi.org/10.1002/ana.21581
ISI Accession Number IDWOS:000264779600012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMi, S
dc.contributor.authorMiller, RH
dc.contributor.authorTang, W
dc.contributor.authorLee, X
dc.contributor.authorHu, B
dc.contributor.authorWu, W
dc.contributor.authorZhang, Y
dc.contributor.authorShields, CB
dc.contributor.authorZhang, Y
dc.contributor.authorMiklasz, S
dc.contributor.authorShea, D
dc.contributor.authorMason, J
dc.contributor.authorFranklin, RJM
dc.contributor.authorJi, B
dc.contributor.authorShao, Z
dc.contributor.authorChédotal, A
dc.contributor.authorBernard, F
dc.contributor.authorRoulois, A
dc.contributor.authorXu, J
dc.contributor.authorJung, V
dc.contributor.authorPepinsky, B
dc.date.accessioned2010-05-31T03:26:25Z
dc.date.available2010-05-31T03:26:25Z
dc.date.issued2009
dc.description.abstractObjective: Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of myelination during repair is poorly understood. In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo. Methods: The effects of LINGO-1 antagonists on the differentiation of OPCs and the promotion of myelination has been assayed using a combination of coculture and slice culture preparations. Using three different animal models of demyelination and remyelination, we morphologically and functionally assessed the effects of LINGO-1 antagonists on OPC differentiation and myelin repair. Results: The data indicate that in vitro treatment with antagonists of LINGO-1 promote OPC differentiation and myelination, whereas in vivo remyelination is accelerated in lysophosphatidylcholine- or cuprizone-induced demyelination. This remyelination is associated with enhanced OPC differentiation and functional recovery of conduction velocities in demyelinated axons. Interpretation: Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination. © 2009 American Neurological Association.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAnnals Of Neurology, 2009, v. 65 n. 3, p. 304-315 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ana.21581
dc.identifier.citeulike6901042
dc.identifier.doihttp://dx.doi.org/10.1002/ana.21581
dc.identifier.epage315
dc.identifier.hkuros163976
dc.identifier.isiWOS:000264779600012
dc.identifier.issn0364-5134
2011 Impact Factor: 11.089
2011 SCImago Journal Rankings: 1.024
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid19334062
dc.identifier.scopuseid_2-s2.0-65249142739
dc.identifier.spage304
dc.identifier.urihttp://hdl.handle.net/10722/58239
dc.identifier.volume65
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
dc.publisher.placeUnited States
dc.relation.ispartofAnnals of Neurology
dc.relation.referencesReferences in Scopus
dc.rightsAnnals of Neurology. Copyright © John Wiley & Sons, Inc.
dc.subject.meshAnimals
dc.subject.meshAnimals, Newborn
dc.subject.meshAntibodies - pharmacology - therapeutic use
dc.subject.meshCell Differentiation - drug effects - physiology
dc.subject.meshCells, Cultured
dc.subject.meshCuprizone - toxicity
dc.subject.meshDemyelinating Autoimmune Diseases, CNS - chemically induced - drug therapy - pathology - physiopathology
dc.subject.meshDisease Models, Animal
dc.subject.meshGanglia, Spinal - cytology
dc.subject.meshLysophosphatidylcholines - toxicity
dc.subject.meshMembrane Proteins - antagonists & inhibitors - immunology - physiology
dc.subject.meshMice
dc.subject.meshMyelin Proteins - metabolism
dc.subject.meshMyelin Sheath - drug effects - physiology
dc.subject.meshNerve Tissue Proteins - antagonists & inhibitors - immunology - physiology
dc.subject.meshOligodendroglia - physiology
dc.subject.meshOrgan Culture Techniques
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshStem Cells - drug effects - physiology
dc.titlePromotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
dc.typeArticle
Author Affiliations
  1. School of Medicine
  2. University of Thomas Jefferson
  3. Universite Pierre et Marie Curie
  4. The University of Hong Kong
  5. Biogen IDEC
  6. null
  7. University of Cambridge, School of Clinical Medicine