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Article: Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

TitlePromotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
Citation
Annals Of Neurology, 2009, v. 65 n. 3, p. 304-315 How to Cite?
AbstractObjective: Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of myelination during repair is poorly understood. In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo. Methods: The effects of LINGO-1 antagonists on the differentiation of OPCs and the promotion of myelination has been assayed using a combination of coculture and slice culture preparations. Using three different animal models of demyelination and remyelination, we morphologically and functionally assessed the effects of LINGO-1 antagonists on OPC differentiation and myelin repair. Results: The data indicate that in vitro treatment with antagonists of LINGO-1 promote OPC differentiation and myelination, whereas in vivo remyelination is accelerated in lysophosphatidylcholine- or cuprizone-induced demyelination. This remyelination is associated with enhanced OPC differentiation and functional recovery of conduction velocities in demyelinated axons. Interpretation: Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination. © 2009 American Neurological Association.
Persistent Identifierhttp://hdl.handle.net/10722/58239
ISSN
2014 Impact Factor: 9.977
2014 SCImago Journal Rankings: 4.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMi, Sen_HK
dc.contributor.authorMiller, RHen_HK
dc.contributor.authorTang, Wen_HK
dc.contributor.authorLee, Xen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorShields, CBen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorMiklasz, Sen_HK
dc.contributor.authorShea, Den_HK
dc.contributor.authorMason, Jen_HK
dc.contributor.authorFranklin, RJMen_HK
dc.contributor.authorJi, Ben_HK
dc.contributor.authorShao, Zen_HK
dc.contributor.authorChédotal, Aen_HK
dc.contributor.authorBernard, Fen_HK
dc.contributor.authorRoulois, Aen_HK
dc.contributor.authorXu, Jen_HK
dc.contributor.authorJung, Ven_HK
dc.contributor.authorPepinsky, Ben_HK
dc.date.accessioned2010-05-31T03:26:25Z-
dc.date.available2010-05-31T03:26:25Z-
dc.date.issued2009en_HK
dc.identifier.citationAnnals Of Neurology, 2009, v. 65 n. 3, p. 304-315en_HK
dc.identifier.issn0364-5134en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58239-
dc.description.abstractObjective: Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of myelination during repair is poorly understood. In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo. Methods: The effects of LINGO-1 antagonists on the differentiation of OPCs and the promotion of myelination has been assayed using a combination of coculture and slice culture preparations. Using three different animal models of demyelination and remyelination, we morphologically and functionally assessed the effects of LINGO-1 antagonists on OPC differentiation and myelin repair. Results: The data indicate that in vitro treatment with antagonists of LINGO-1 promote OPC differentiation and myelination, whereas in vivo remyelination is accelerated in lysophosphatidylcholine- or cuprizone-induced demyelination. This remyelination is associated with enhanced OPC differentiation and functional recovery of conduction velocities in demyelinated axons. Interpretation: Our studies demonstrate that LINGO-1 antagonism promotes OPC differentiation and remyelination, and suggest LINGO-1 functions as an inhibitor of OPC differentiation to retard central nervous system remyelination. © 2009 American Neurological Association.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645en_HK
dc.relation.ispartofAnnals of Neurologyen_HK
dc.rightsAnnals of Neurology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshAntibodies - pharmacology - therapeutic useen_HK
dc.subject.meshCell Differentiation - drug effects - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshCuprizone - toxicityen_HK
dc.subject.meshDemyelinating Autoimmune Diseases, CNS - chemically induced - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshGanglia, Spinal - cytologyen_HK
dc.subject.meshLysophosphatidylcholines - toxicityen_HK
dc.subject.meshMembrane Proteins - antagonists & inhibitors - immunology - physiologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMyelin Proteins - metabolismen_HK
dc.subject.meshMyelin Sheath - drug effects - physiologyen_HK
dc.subject.meshNerve Tissue Proteins - antagonists & inhibitors - immunology - physiologyen_HK
dc.subject.meshOligodendroglia - physiologyen_HK
dc.subject.meshOrgan Culture Techniquesen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStem Cells - drug effects - physiologyen_HK
dc.titlePromotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0364-5134&volume=65&spage=304&epage=315&date=2009&atitle=Promotion+of+central+nervous+system+remyelination+by+induced+differentiation+of+oligodendrocyte+precursor+cellsen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ana.21581en_HK
dc.identifier.pmid19334062en_HK
dc.identifier.scopuseid_2-s2.0-65249142739en_HK
dc.identifier.hkuros163976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65249142739&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue3en_HK
dc.identifier.spage304en_HK
dc.identifier.epage315en_HK
dc.identifier.eissn1531-8249-
dc.identifier.isiWOS:000264779600012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMi, S=7004825561en_HK
dc.identifier.scopusauthoridMiller, RH=7501581309en_HK
dc.identifier.scopusauthoridTang, W=55231732300en_HK
dc.identifier.scopusauthoridLee, X=36710111000en_HK
dc.identifier.scopusauthoridHu, B=35733928400en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridZhang, Y=9244115200en_HK
dc.identifier.scopusauthoridShields, CB=7201520455en_HK
dc.identifier.scopusauthoridZhang, Y=7601325035en_HK
dc.identifier.scopusauthoridMiklasz, S=36867109100en_HK
dc.identifier.scopusauthoridShea, D=7006041046en_HK
dc.identifier.scopusauthoridMason, J=7403552597en_HK
dc.identifier.scopusauthoridFranklin, RJM=12780014100en_HK
dc.identifier.scopusauthoridJi, B=7102566175en_HK
dc.identifier.scopusauthoridShao, Z=7202244441en_HK
dc.identifier.scopusauthoridChédotal, A=7003925863en_HK
dc.identifier.scopusauthoridBernard, F=55137281800en_HK
dc.identifier.scopusauthoridRoulois, A=8606167300en_HK
dc.identifier.scopusauthoridXu, J=36711035700en_HK
dc.identifier.scopusauthoridJung, V=7006727074en_HK
dc.identifier.scopusauthoridPepinsky, B=6603558137en_HK
dc.identifier.citeulike6901042-

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