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Article: Increased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model
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TitleIncreased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model
 
AuthorsLee, YL1
Ng, HP1
Lau, KS1
Liu, WM1
O, WS1
Yeung, WSB1
Kung, AWC1
 
Keywordsabortion
Autoimmune thyroiditis
implantation rate
preimplantation embryo development
thyroid peroxidase
 
Issue Date2009
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
 
CitationFertility And Sterility, 2009, v. 91 n. 5 SUPPL., p. 2104-2109 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704
 
AbstractObjective: To determine the fertility and abortion rates in a mouse model of autoimmune thyroiditis and its relationship with circulating anti-thyroid peroxidase (TPO) antibody. Design: Experimental animal study. Setting: University research laboratory. Animal(s): C57bl/6 mice. Intervention(s): Female C57bl/6 mice immunized with recombinant mouse TPO (rmTPO) in complete Freund adjuvant (CFA) or glutathione-S-transferase (GST-CFA) were allowed to mate. The pregnant mice were killed on day 14 of pregnancy for assessment of fetal development. The effects of TPO antibody on preimplantation embryo development and implantation rate were also studied. Main Outcome Measure(s): Litter size, resorption rate, preimplantation embryo development, and implantation rate. Result(s): All of the mice immunized with rmTPO-CFA possessed anti-TPO antibody. They had reduced litter size and increased incidence of resorbed fetus compared with the control. Higher serum TSH levels, but not T 4 levels, were demonstrated after rmTPO-CFA immunization. Anti-TPO antibody bound to preimplantation embryos. Treatment of the embryos with the antibody marginally decreased the formation of 3/4-cell embryos but had no effect on the subsequent development and implantation compared with the nonimmune control sera. Conclusion(s): Autoimmune thyroiditis is associated with reduced fertility and higher incidence of fetal loss. The anti-TPO antibody may affect post-implantation embryo development, leading to fetal loss. © 2009 American Society for Reproductive Medicine.
 
ISSN0015-0282
2012 Impact Factor: 4.174
2012 SCImago Journal Rankings: 1.275
 
DOIhttp://dx.doi.org/10.1016/j.fertnstert.2008.07.1704
 
ISI Accession Number IDWOS:000265969300018
Funding AgencyGrant Number
Committee on Research and Conference Grants (CRCG)
Endocrine and Osteoporosis Research Fund, University of Hong Kong
Funding Information:

Supported by Committee on Research and Conference Grants (CRCG) grant and Endocrine and Osteoporosis Research Fund, University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLee, YL
 
dc.contributor.authorNg, HP
 
dc.contributor.authorLau, KS
 
dc.contributor.authorLiu, WM
 
dc.contributor.authorO, WS
 
dc.contributor.authorYeung, WSB
 
dc.contributor.authorKung, AWC
 
dc.date.accessioned2010-05-31T03:26:10Z
 
dc.date.available2010-05-31T03:26:10Z
 
dc.date.issued2009
 
dc.description.abstractObjective: To determine the fertility and abortion rates in a mouse model of autoimmune thyroiditis and its relationship with circulating anti-thyroid peroxidase (TPO) antibody. Design: Experimental animal study. Setting: University research laboratory. Animal(s): C57bl/6 mice. Intervention(s): Female C57bl/6 mice immunized with recombinant mouse TPO (rmTPO) in complete Freund adjuvant (CFA) or glutathione-S-transferase (GST-CFA) were allowed to mate. The pregnant mice were killed on day 14 of pregnancy for assessment of fetal development. The effects of TPO antibody on preimplantation embryo development and implantation rate were also studied. Main Outcome Measure(s): Litter size, resorption rate, preimplantation embryo development, and implantation rate. Result(s): All of the mice immunized with rmTPO-CFA possessed anti-TPO antibody. They had reduced litter size and increased incidence of resorbed fetus compared with the control. Higher serum TSH levels, but not T 4 levels, were demonstrated after rmTPO-CFA immunization. Anti-TPO antibody bound to preimplantation embryos. Treatment of the embryos with the antibody marginally decreased the formation of 3/4-cell embryos but had no effect on the subsequent development and implantation compared with the nonimmune control sera. Conclusion(s): Autoimmune thyroiditis is associated with reduced fertility and higher incidence of fetal loss. The anti-TPO antibody may affect post-implantation embryo development, leading to fetal loss. © 2009 American Society for Reproductive Medicine.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationFertility And Sterility, 2009, v. 91 n. 5 SUPPL., p. 2104-2109 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.fertnstert.2008.07.1704
 
dc.identifier.epage2109
 
dc.identifier.hkuros152583
 
dc.identifier.isiWOS:000265969300018
Funding AgencyGrant Number
Committee on Research and Conference Grants (CRCG)
Endocrine and Osteoporosis Research Fund, University of Hong Kong
Funding Information:

Supported by Committee on Research and Conference Grants (CRCG) grant and Endocrine and Osteoporosis Research Fund, University of Hong Kong.

 
dc.identifier.issn0015-0282
2012 Impact Factor: 4.174
2012 SCImago Journal Rankings: 1.275
 
dc.identifier.issue5 SUPPL.
 
dc.identifier.openurl
 
dc.identifier.pmid18774556
 
dc.identifier.scopuseid_2-s2.0-65249160685
 
dc.identifier.spage2104
 
dc.identifier.urihttp://hdl.handle.net/10722/58225
 
dc.identifier.volume91
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
 
dc.publisher.placeUnited States
 
dc.relation.ispartofFertility and Sterility
 
dc.relation.referencesReferences in Scopus
 
dc.rightsFertility and Sterility. Copyright © Elsevier Inc.
 
dc.subject.meshAbortion, Spontaneous - epidemiology - etiology
 
dc.subject.meshAnimals
 
dc.subject.meshAutoantibodies - blood
 
dc.subject.meshBlastocyst - immunology
 
dc.subject.meshDisease Models, Animal
 
dc.subject.meshFemale
 
dc.subject.meshIodide Peroxidase - blood - genetics - immunology
 
dc.subject.meshLitter Size
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred C57BL
 
dc.subject.meshPregnancy
 
dc.subject.meshPregnancy Complications - immunology
 
dc.subject.meshThyroiditis, Autoimmune - immunology
 
dc.subject.meshThyrotropin - blood
 
dc.subject.meshThyroxine - blood
 
dc.subjectabortion
 
dc.subjectAutoimmune thyroiditis
 
dc.subjectimplantation rate
 
dc.subjectpreimplantation embryo development
 
dc.subjectthyroid peroxidase
 
dc.titleIncreased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model
 
dc.typeArticle
 
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<subject.mesh>Blastocyst - immunology</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong