Article: Increased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model
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- Publisher Website: 10.1016/j.fertnstert.2008.07.1704
- Scopus: eid_2-s2.0-65249160685
- PMID: 18774556
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| Title | Increased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Lee, YL1 Ng, HP1 Lau, KS1 Liu, WM1 O, WS1 Yeung, WSB1 Kung, AWC1 | ||||||
| Keywords | abortion Autoimmune thyroiditis implantation rate preimplantation embryo development thyroid peroxidase | ||||||
| Issue Date | 2009 | ||||||
| Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert | ||||||
| Citation | Fertility And Sterility, 2009, v. 91 n. 5 SUPPL., p. 2104-2109 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704 | ||||||
| Abstract | Objective: To determine the fertility and abortion rates in a mouse model of autoimmune thyroiditis and its relationship with circulating anti-thyroid peroxidase (TPO) antibody. Design: Experimental animal study. Setting: University research laboratory. Animal(s): C57bl/6 mice. Intervention(s): Female C57bl/6 mice immunized with recombinant mouse TPO (rmTPO) in complete Freund adjuvant (CFA) or glutathione-S-transferase (GST-CFA) were allowed to mate. The pregnant mice were killed on day 14 of pregnancy for assessment of fetal development. The effects of TPO antibody on preimplantation embryo development and implantation rate were also studied. Main Outcome Measure(s): Litter size, resorption rate, preimplantation embryo development, and implantation rate. Result(s): All of the mice immunized with rmTPO-CFA possessed anti-TPO antibody. They had reduced litter size and increased incidence of resorbed fetus compared with the control. Higher serum TSH levels, but not T 4 levels, were demonstrated after rmTPO-CFA immunization. Anti-TPO antibody bound to preimplantation embryos. Treatment of the embryos with the antibody marginally decreased the formation of 3/4-cell embryos but had no effect on the subsequent development and implantation compared with the nonimmune control sera. Conclusion(s): Autoimmune thyroiditis is associated with reduced fertility and higher incidence of fetal loss. The anti-TPO antibody may affect post-implantation embryo development, leading to fetal loss. © 2009 American Society for Reproductive Medicine. | ||||||
| ISSN | 0015-0282 2011 Impact Factor: 3.564 2011 SCImago Journal Rankings: 0.190 | ||||||
| DOI | http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704 | ||||||
| ISI Accession Number ID | WOS:000265969300018
Funding Information: Supported by Committee on Research and Conference Grants (CRCG) grant and Endocrine and Osteoporosis Research Fund, University of Hong Kong. | ||||||
| References | References in Scopus |
| dc.contributor.author | Lee, YL | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Ng, HP | ||||||
| dc.contributor.author | Lau, KS | ||||||
| dc.contributor.author | Liu, WM | ||||||
| dc.contributor.author | O, WS | ||||||
| dc.contributor.author | Yeung, WSB | ||||||
| dc.contributor.author | Kung, AWC | ||||||
| dc.date.accessioned | 2010-05-31T03:26:10Z | ||||||
| dc.date.available | 2010-05-31T03:26:10Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | Objective: To determine the fertility and abortion rates in a mouse model of autoimmune thyroiditis and its relationship with circulating anti-thyroid peroxidase (TPO) antibody. Design: Experimental animal study. Setting: University research laboratory. Animal(s): C57bl/6 mice. Intervention(s): Female C57bl/6 mice immunized with recombinant mouse TPO (rmTPO) in complete Freund adjuvant (CFA) or glutathione-S-transferase (GST-CFA) were allowed to mate. The pregnant mice were killed on day 14 of pregnancy for assessment of fetal development. The effects of TPO antibody on preimplantation embryo development and implantation rate were also studied. Main Outcome Measure(s): Litter size, resorption rate, preimplantation embryo development, and implantation rate. Result(s): All of the mice immunized with rmTPO-CFA possessed anti-TPO antibody. They had reduced litter size and increased incidence of resorbed fetus compared with the control. Higher serum TSH levels, but not T 4 levels, were demonstrated after rmTPO-CFA immunization. Anti-TPO antibody bound to preimplantation embryos. Treatment of the embryos with the antibody marginally decreased the formation of 3/4-cell embryos but had no effect on the subsequent development and implantation compared with the nonimmune control sera. Conclusion(s): Autoimmune thyroiditis is associated with reduced fertility and higher incidence of fetal loss. The anti-TPO antibody may affect post-implantation embryo development, leading to fetal loss. © 2009 American Society for Reproductive Medicine. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Fertility And Sterility, 2009, v. 91 n. 5 SUPPL., p. 2104-2109 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.fertnstert.2008.07.1704 | ||||||
| dc.identifier.epage | 2109 | ||||||
| dc.identifier.hkuros | 152583 | ||||||
| dc.identifier.isi | WOS:000265969300018
Funding Information: Supported by Committee on Research and Conference Grants (CRCG) grant and Endocrine and Osteoporosis Research Fund, University of Hong Kong. | ||||||
| dc.identifier.issn | 0015-0282 2011 Impact Factor: 3.564 2011 SCImago Journal Rankings: 0.190 | ||||||
| dc.identifier.issue | 5 SUPPL. | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 18774556 | ||||||
| dc.identifier.scopus | eid_2-s2.0-65249160685 | ||||||
| dc.identifier.spage | 2104 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/58225 | ||||||
| dc.identifier.volume | 91 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Fertility and Sterility | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Fertility and Sterility. Copyright © Elsevier Inc. | ||||||
| dc.subject.mesh | Abortion, Spontaneous - epidemiology - etiology | ||||||
| dc.subject.mesh | Animals | ||||||
| dc.subject.mesh | Autoantibodies - blood | ||||||
| dc.subject.mesh | Blastocyst - immunology | ||||||
| dc.subject.mesh | Disease Models, Animal | ||||||
| dc.subject.mesh | Female | ||||||
| dc.subject.mesh | Iodide Peroxidase - blood - genetics - immunology | ||||||
| dc.subject.mesh | Litter Size | ||||||
| dc.subject.mesh | Mice | ||||||
| dc.subject.mesh | Mice, Inbred C57BL | ||||||
| dc.subject.mesh | Pregnancy | ||||||
| dc.subject.mesh | Pregnancy Complications - immunology | ||||||
| dc.subject.mesh | Thyroiditis, Autoimmune - immunology | ||||||
| dc.subject.mesh | Thyrotropin - blood | ||||||
| dc.subject.mesh | Thyroxine - blood | ||||||
| dc.subject | abortion | ||||||
| dc.subject | Autoimmune thyroiditis | ||||||
| dc.subject | implantation rate | ||||||
| dc.subject | preimplantation embryo development | ||||||
| dc.subject | thyroid peroxidase | ||||||
| dc.title | Increased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong