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Article: Implantation of neurotrophic factor-treated sensory nerve graft enhances survival and axonal regeneration of motoneurons after spinal root avulsion

TitleImplantation of neurotrophic factor-treated sensory nerve graft enhances survival and axonal regeneration of motoneurons after spinal root avulsion
Authors
KeywordsAvulsion
Brain-derived neurotrophic factor
Ciliary neurotrophic factor
Glial cell line-derived neurotrophic factor
Peripheral nerve graft
Pleiotrophin
Regeneration
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jneuropath.com
Citation
Journal Of Neuropathology And Experimental Neurology, 2009, v. 68 n. 1, p. 94-101 How to Cite?
AbstractWe previously showed that motor nerves are superior to sensory nerves in promoting axon regeneration after spinal root avulsion. It is, however, impractical to use motor nerves as grafts. One potential approach to enhancing axonal regeneration using sensory nerves is to deliver trophic factors to the graft. Here, we examined the regulation of receptors for brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, and pleiotrophin after root avulsion in adult rats. We then tested their survival-promoting and neuroregenerative effects on spinal motoneurons. The results showed that receptors for brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor were upregulated and that these trophic factors promoted survival and axonal regeneration of motoneurons when they were injected into the sensory nerve graft before implantation. In contrast, receptors for ciliary neurotrophic factor and pleiotrophin were downregulated after avulsion. Ciliary neurotrophic factor did not promote survival and axonal regeneration, whereas pleiotrophin promoted axonal regeneration but not survival of injured spinal motoneurons. Our results suggest that infusion of trophic factors into sensory nerve grafts promote motoneuron survival and axonal regeneration. The technique is technically easy and is, therefore, potentially clinically applicable. © 2008 by the American Association of Neuropathologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58220
ISSN
2014 Impact Factor: 3.797
2014 SCImago Journal Rankings: 1.832
References

 

DC FieldValueLanguage
dc.contributor.authorChu, THen_HK
dc.contributor.authorLi, SYen_HK
dc.contributor.authorGuo, Aen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-05-31T03:26:04Z-
dc.date.available2010-05-31T03:26:04Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Neuropathology And Experimental Neurology, 2009, v. 68 n. 1, p. 94-101en_HK
dc.identifier.issn0022-3069en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58220-
dc.description.abstractWe previously showed that motor nerves are superior to sensory nerves in promoting axon regeneration after spinal root avulsion. It is, however, impractical to use motor nerves as grafts. One potential approach to enhancing axonal regeneration using sensory nerves is to deliver trophic factors to the graft. Here, we examined the regulation of receptors for brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, and pleiotrophin after root avulsion in adult rats. We then tested their survival-promoting and neuroregenerative effects on spinal motoneurons. The results showed that receptors for brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor were upregulated and that these trophic factors promoted survival and axonal regeneration of motoneurons when they were injected into the sensory nerve graft before implantation. In contrast, receptors for ciliary neurotrophic factor and pleiotrophin were downregulated after avulsion. Ciliary neurotrophic factor did not promote survival and axonal regeneration, whereas pleiotrophin promoted axonal regeneration but not survival of injured spinal motoneurons. Our results suggest that infusion of trophic factors into sensory nerve grafts promote motoneuron survival and axonal regeneration. The technique is technically easy and is, therefore, potentially clinically applicable. © 2008 by the American Association of Neuropathologists, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jneuropath.comen_HK
dc.relation.ispartofJournal of Neuropathology and Experimental Neurologyen_HK
dc.subjectAvulsionen_HK
dc.subjectBrain-derived neurotrophic factoren_HK
dc.subjectCiliary neurotrophic factoren_HK
dc.subjectGlial cell line-derived neurotrophic factoren_HK
dc.subjectPeripheral nerve graften_HK
dc.subjectPleiotrophinen_HK
dc.subjectRegenerationen_HK
dc.titleImplantation of neurotrophic factor-treated sensory nerve graft enhances survival and axonal regeneration of motoneurons after spinal root avulsionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3069&volume=68&spage=94&epage=101&date=2009&atitle=Implantation+of+neurotrophic+factor-treated+sensory+nerve+graft+enhances+survival+and+axonal+regeneration+of+motoneurons+after+spinal+root+avulsionen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/NEN.0b013e31819344a9en_HK
dc.identifier.scopuseid_2-s2.0-64049090493en_HK
dc.identifier.hkuros154469en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64049090493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue1en_HK
dc.identifier.spage94en_HK
dc.identifier.epage101en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, TH=14023966500en_HK
dc.identifier.scopusauthoridLi, SY=24329630700en_HK
dc.identifier.scopusauthoridGuo, A=55137882000en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridYuan, Q=7202814773en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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